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Tdark Probable histone-lysine N-methyltransferase PRDM7

Probable histone methyltransferase.

This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]

 Comments

Property Summary

NCBI Gene PubMed Count 8
PubMed Score 2.69
PubTator Score 2.86

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
diabetes mellitus 1728 2.0e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Li-Fraumeni syndrome 13 3.332 1.7
Turner syndrome 28 3.252 1.6

Expression

  Differential Expression (1)

Disease log2 FC p
diabetes mellitus 1.200 2.0e-03

Synonym

Accession Q9NQW5 A4Q9G8 Q08EM4 Q9NQW4
Symbols PFM4
ZNF910

Gene

PRDM7

  Ortholog (1)

Species Source Disease
Inparanoid OMA

 UniProt Keyword (10)

 GO Function (2)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (13)

 HCA RNA Cell Line (9)

Pathway (4)

Gene RIF (3)

AA Sequence 

MSPERSQEESPEGDTERTERKPMVKDAFKDISIYFTKEEWAEMGDWEKTRYRNVKMNYNALITVGLRATR      1 - 70
PAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVKPPWMAFRGEQSKHQKGMPKASFNNESSLRELSGTPNLL     71 - 140
NTSDSEQAQKPVSPPGEASTSGQHSRLKLELRRKETEGKMYSLRERKGHAYKEISEPQDDDYLYCEMCQN    141 - 210
FFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRI    211 - 280
TEDEEAANSGYSWLITKGRNCYEYVDGKDKSSANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPG    281 - 350
CELLVWSGDEYGQELGIRSSIEPAESLGQAVNCWSGMGMSMARNWASSGAASGRKSSWQGENQSQRSIHV    351 - 420
PHAVWPFQVKNFSVNMWNAITPLRTSQDHLQENFSNQRIPAQGIRIRSGNILIHAAVMTKPKVKRSKKGP    421 - 490
NS                                                                        491 - 492
//

Text Mined References (9)

PMID Year Title