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Tbio
PRAME
Melanoma antigen preferentially expressed in tumors

Protein Summary
Description
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398741
  • ENSP00000381726
  • ENSG00000185686
  • ENST00000398743
  • ENSP00000381728
  • ENST00000402697
  • ENSP00000385198
  • ENST00000405655
  • ENSP00000384343
  • ENST00000539862
  • ENSP00000445097
  • ENSG00000275013
  • ENST00000543184
  • ENSP00000445675
  • ENST00000617728
  • ENSP00000484066
  • ENST00000626503
  • ENSP00000486485
  • ENST00000628830
  • ENSP00000486330

Symbol
  • MAPE
  • OIP4
  • MAPE
  • OIP4
  • CT130
  • OIP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
biological process
0.71
tissue sample
0.7
biological term
0.67
tissue
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.88   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.88   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0