| Tbio | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform |
Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Comments
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Bipolar Disorder | 666 |
| Depressive disorder | 409 |
| Mental Depression | 333 |
| Nonorganic psychosis | 84 |
| Psychotic Disorders | 151 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.9e-10 |
| ovarian cancer | 8520 | 1.5e-08 |
| malignant mesothelioma | 3232 | 3.7e-07 |
| osteosarcoma | 7950 | 1.5e-05 |
| psoriasis | 6694 | 2.4e-04 |
| group 4 medulloblastoma | 1855 | 4.6e-04 |
| lung cancer | 4740 | 1.3e-03 |
| medulloblastoma, large-cell | 6241 | 1.5e-03 |
| active ulcerative colitis | 764 | 2.0e-02 |
| non primary Sjogren syndrome sicca | 891 | 2.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired immunodeficiency syndrome | 197 | 0.0 | 0.7 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Melancholia | 10 | 3.246 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | -1.245 | 2.0e-02 |
| group 4 medulloblastoma | -1.100 | 4.6e-04 |
| lung adenocarcinoma | -1.200 | 1.9e-10 |
| lung cancer | -1.200 | 1.3e-03 |
| malignant mesothelioma | -2.100 | 3.7e-07 |
| medulloblastoma, large-cell | -1.600 | 1.5e-03 |
| non primary Sjogren syndrome sicca | 1.100 | 2.3e-02 |
| osteosarcoma | -2.188 | 1.5e-05 |
| ovarian cancer | -1.100 | 1.5e-08 |
| psoriasis | -1.800 | 2.4e-04 |
MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQ 1 - 70 EKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTL 71 - 140 FLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRK 141 - 210 LDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQ 211 - 280 DAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSL 281 - 350 PFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGL 351 - 420 TPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPM 421 - 490 KSVTSAHSHAAHRSDQGKKAHS 491 - 512 //
