Tbio PPP1R14D Protein phosphatase 1 regulatory subunit 14D

Protein Summary

Description

Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]

Uniprot Accession IDs

• Q9NXH3
• Q4V773

Gene Name

• PPP1R14D

Ensembl ID

• ENST00000299174
• ENSP00000299174
• ENSG00000166143

Symbol

• GBPI
• GBPI1
• GBPI-1
• CPI17-like

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.63
kinase perturbation	0.54
gene perturbation	0.48
cell line	0.45
PubMedID	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.21   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.21   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0