Tchem PPM1B Protein phosphatase 1B

Protein Summary

Description

Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75688
• Q461Q2
• Q4J6C1
• Q4J6C2
• Q658R4
• Q96ER6
• Q9HAY8

Gene Name

• PPM1B

Ensembl ID

• ENST00000282412
• ENSP00000282412
• ENSG00000138032
• ENST00000345249
• ENSP00000326089
• ENST00000378551
• ENSP00000367813
• ENST00000409432
• ENSP00000387287

Symbol

• PP2CB
• PP2CB
• PP2CBETA
• PP2C-beta
• PPC2BETAX
• PP2C-beta-X

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.98
virus perturbation	0.98
kinase perturbation	0.95
interacting protein	0.93
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1b

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Protein Phosphatase 1b

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Protein Phosphatase 1b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.09   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 315   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.09   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 315   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0