Tbio PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Protein Summary

Description

Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• Q6PFW1
• O15082
• Q5HYF8
• Q7Z3A7
• Q86TE7
• Q86UV3
• Q86UV4
• Q86XW8
• Q8IZN0

Gene Name

• PPIP5K1

Ensembl ID

• ENST00000334933
• ENSP00000334779
• ENSG00000168781
• ENST00000348806
• ENSP00000308773
• ENST00000360135
• ENSP00000353253
• ENST00000360301
• ENSP00000353446
• ENST00000396923
• ENSP00000380129
• ENST00000420765
• ENSP00000400887

Symbol

• HISPPD2A
• IP6K
• IPS1
• KIAA0377
• VIP1
• IP6K
• IPS1
• VIP1
• hsVIP1
• HISPPD2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
hub protein	0.88
virus perturbation	0.72
cell type or tissue	0.59
tissue	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 44   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0