| Tbio | Peptidyl-prolyl cis-trans isomerase-like 2 |
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 1.8e-06 |
| medulloblastoma, large-cell | 6241 | 4.4e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.2e-03 |
| astrocytic glioma | 2597 | 3.1e-02 |
| oligodendroglioma | 2850 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| multidrug-resistant tuberculosis | 7 | 3.588 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.300 | 3.1e-02 |
| intraductal papillary-mucinous adenoma (... | 1.700 | 2.7e-03 |
| intraductal papillary-mucinous carcinoma... | 1.400 | 5.2e-03 |
| medulloblastoma, large-cell | 1.600 | 4.4e-05 |
| oligodendroglioma | 1.200 | 4.4e-02 |
| osteosarcoma | -1.107 | 1.8e-06 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWL 1 - 70 KKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKN 71 - 140 FRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQE 141 - 210 LYKEFKGDEILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKG 211 - 280 YVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPF 281 - 350 KDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTD 351 - 420 RPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATK 421 - 490 RAAEEEPSTSATVPMSKKKPSRGFGDFSSW 491 - 520 //
