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Tbio Peptidyl-prolyl cis-trans isomerase H

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 15
PubMed Score 23.31
PubTator Score 11.90

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
malignant mesothelioma 3232 9.2e-06
ovarian cancer 8520 1.4e-03
group 3 medulloblastoma 4104 1.6e-03
lung cancer 4740 2.6e-03
oligodendroglioma 2850 6.1e-03
ependymoma 4679 1.0e-02

Expression

  Differential Expression (6)

Disease log2 FC p
ependymoma -1.100 1.0e-02
group 3 medulloblastoma 1.200 1.6e-03
lung cancer 1.300 2.6e-03
malignant mesothelioma 1.500 9.2e-06
oligodendroglioma -1.100 6.1e-03
ovarian cancer 1.100 1.4e-03

Synonym

Accession O43447 A6NNE7 PPIase H
Symbols CYPH
CYP-20
USA-CYP
SnuCyp-20

Gene

PPIH

PDB

5O9Z   1MZW   1QOI  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (3)

 GO Component (6)

 GO Process (4)

 Compartment GO Term (33)

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 HCA RNA Cell Line (56)

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Pathway (5)

Gene RIF (2)

AA Sequence 

MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGYKGSTFHRVIK      1 - 70
DFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTNGCQFFITCSKCDWLDGKHVV     71 - 140
FGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM                                     141 - 177
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Text Mined References (21)

PMID Year Title