| Tbio | Peptidyl-prolyl cis-trans isomerase H |
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| malignant mesothelioma | 3232 | 9.2e-06 |
| ovarian cancer | 8520 | 1.4e-03 |
| group 3 medulloblastoma | 4104 | 1.6e-03 |
| lung cancer | 4740 | 2.6e-03 |
| oligodendroglioma | 2850 | 6.1e-03 |
| ependymoma | 4679 | 1.0e-02 |
| Disease | log2 FC | p |
|---|---|---|
| ependymoma | -1.100 | 1.0e-02 |
| group 3 medulloblastoma | 1.200 | 1.6e-03 |
| lung cancer | 1.300 | 2.6e-03 |
| malignant mesothelioma | 1.500 | 9.2e-06 |
| oligodendroglioma | -1.100 | 6.1e-03 |
| ovarian cancer | 1.100 | 1.4e-03 |
