| Tbio | Phosphopantothenoylcysteine decarboxylase |
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 1.4e-07 |
| tuberculosis | 2010 | 3.1e-05 |
| ovarian cancer | 8520 | 1.2e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| substance-related disorder | 162 | 0.0 | 1.9 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Obstructive sleep apnea | 26 | 4.06 | 2.0 |
| Congenital bile acid synthesis defect | 15 | 3.632 | 1.8 |
| Central sleep apnea | 11 | 3.52 | 1.8 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | -2.619 | 1.4e-07 |
| ovarian cancer | 1.200 | 1.2e-03 |
| tuberculosis | -1.200 | 3.1e-05 |
