1. Home
  2. Targets
  3. Phosphopantothenoylcysteine decarboxylase

Tbio Phosphopantothenoylcysteine decarboxylase

Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.

Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCDC (EC 4.1.1.36), one of the last enzymes in this pathway, converts phosphopantothenoylcysteine to 4-prime-phosphopantetheine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 30.32
PubTator Score 6.81

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count P-value
osteosarcoma 7950 1.4e-07
tuberculosis 2010 3.1e-05
ovarian cancer 8520 1.2e-03
Disease Target Count Z-score Confidence
substance-related disorder 162 0.0 1.9

Expression

  Differential Expression (3)

Disease log2 FC p
osteosarcoma -2.619 1.4e-07
ovarian cancer 1.200 1.2e-03
tuberculosis -1.200 3.1e-05

Synonym

Accession Q96CD2 Q96SX0 Q9HC17 PPC-DC
Symbols coaC
MDS018
PPC-DC

Gene

PPCDC

  Ortholog (16)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA

 UniProt Keyword (10)

 GO Function (2)

 GO Component (1)

 GO Process (2)

 Compartment GO Term (8)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

See all...

Pathway (10)

PDB (1)

AA Sequence 

MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFYSPQDIPVTLY      1 - 70
SDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLLTCVMRAWDRSKPLLFCPAMN     71 - 140
TAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGAMAEVGTIVDKVKEVLFQHSGFQQS          141 - 204
//

Text Mined References (13)

PMID Year Title