Property Summary

NCBI Gene PubMed Count 1,673
PubMed Score 8950.62
PubTator Score 4693.16

Knowledge Summary

Patent (119,840)

TINX Plot

  Disease (8)

Disease Target Count Z-score Confidence
Acquired metabolic disease 267 0.0 2.0
Type 2 diabetes mellitus 192 0.0 1.0
Disease Target Count Z-score Confidence
diabetes mellitus 1663 6.825 3.4

Expression

  Differential Expression (24)

Disease log2 FC p
psoriasis -1.300 2.8e-06
esophageal adenocarcinoma 1.200 3.0e-02
osteosarcoma -1.655 8.3e-03
posterior fossa group A ependymoma 2.200 2.5e-08
medulloblastoma, large-cell -1.300 2.0e-04
primitive neuroectodermal tumor -1.100 2.7e-03
Atopic dermatitis -1.400 5.9e-03
tuberculosis -3.800 1.8e-09
non-small cell lung cancer -2.202 1.1e-20
intraductal papillary-mucinous adenoma (... 1.900 3.7e-04
intraductal papillary-mucinous carcinoma... 1.500 2.7e-02
intraductal papillary-mucinous neoplasm ... 2.500 1.5e-03
lung cancer -3.400 1.7e-06
ulcerative colitis -1.900 3.7e-05
pancreatic cancer 1.500 2.4e-04
breast carcinoma -2.300 6.1e-04
fibroadenoma -2.800 1.1e-02
interstitial cystitis -3.300 3.9e-05
lung adenocarcinoma -1.800 4.4e-08
group 4 medulloblastoma -1.100 9.2e-05
invasive ductal carcinoma -3.500 3.9e-04
lung carcinoma -2.700 1.9e-17
mucosa-associated lymphoid tissue lympho... 2.329 4.9e-02
ductal carcinoma in situ -2.900 2.5e-04

Synonym

Accession P37231 A8K3G6 B5BUA1 O00684 O00710 O14515 Q0QJH8 Q15178 Q15179 Q15180 Q15832 Q86U60 Q96J12 PPAR-gamma
Symbols GLM1
CIMT1
NR1C3
PPARG1
PPARG2
PPARgamma

Gene

PDB

1FM6   1FM9   1I7I   1K74   1KNU   1NYX   1PRG   1RDT   1WM0   1ZEO   1ZGY   2ATH   2F4B   2FVJ   2G0G   2G0H   2GTK   2HFP   2HWQ   2HWR   2I4J   2I4P   2I4Z   2OM9   2P4Y   2POB   2PRG   2Q59   2Q5P   2Q5S   2Q61   2Q6R   2Q6S   2Q8S   2QMV   2VSR   2VST   2VV0   2VV1   2VV2   2VV3   2VV4   2XKW   2YFE   2ZK0   2ZK1   2ZK2   2ZK3   2ZK4   2ZK5   2ZK6   2ZNO   2ZVT   3ADS   3ADT   3ADU   3ADV   3ADW   3ADX   3AN3   3AN4   3B0Q   3B0R   3B1M   3B3K   3BC5   3CDP   3CDS   3CS8   3CWD   3D6D   3DZU   3DZY   3E00   3ET0   3ET3   3FEJ   3FUR   3G9E   3GBK   3H0A   3HO0   3HOD   3IA6   3K8S   3KMG   3LMP   3NOA   3OSI   3OSW   3PBA   3PO9   3PRG   3QT0   3R5N   3R8A   3R8I   3S9S   3SZ1   3T03   3TY0   3U9Q   3V9T   3V9V   3V9Y   3VJH   3VJI   3VN2   3VSO   3VSP   3WJ4   3WJ5   3WMH   3X1H   3X1I   4A4V   4A4W   4CI5   4E4K   4E4Q   4EM9   4EMA   4F9M   4FGY   4HEE   4JAZ   4JL4   4L96   4L98   4O8F   4OJ4   4PRG   4PVU   4PWL   4R06   4R2U   4R6S   4XLD   4XTA   4XUH   4XUM   4Y29   4YT1   5AZV   5DSH   5DV3   5DV6   5DV8   5DWL   5F9B  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

  TechDev Info (1)

Jun Qin 39 Signaling network evaluation of transcript factor crosstalk via catTRE/MS

Protein-protein Interaction (11)

MLP Assay (9)

AID Type Active / Inconclusive / Inactive Description
2277 screening 14 / 0 / 0 Center Based Initiative to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors.
504446 confirmatory 11 / 0 / 5 TR-FRET-based biochemical dose response competitive binding lanthascreen assay for partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg)
504447 confirmatory 24 / 0 / 46 Luminescence-based cell-based assay provider high throughput dose response assay for partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg)
504452 screening 60 / 0 / 175 Luminescence-based cell-based primary high throughput screening assay to identify partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg)
504453 confirmatory 7 / 0 / 12 Fluorescence-polarization-based biochemical polarscreen dose response binding assay for partial agonists of the peroxisome proliferator-activated receptor gamma (PPARg)
504934 other 1 / 0 / 0 Late stage assay provider results from the probe development effort to identify inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): luminescence-based high throughput cell-based assay to identify modulators of human nuclear receptors
504939 confirmatory 6 / 0 / 2 Late stage assay provider results from the probe development effort to identify non-agonists of the peroxisome proliferator-activated receptor gamma (PPARg): Luminescence-based cell-based dose response assay to identify transactivation inhibitor of PPRE (PPARG response element)
504943 confirmatory 9 / 0 / 1 Late stage assay provider results from the probe development effort to identify non-agonists of the peroxisome proliferator-activated receptor gamma (PPARg): TR-FRET-based biochemical dose response competitive binding lanthascreen assay for non-agonists of the PPARg
540293 other 1 / 0 / 0 Late stage assay provider counterscreen results from the probe development effort to identify non-agonists of the peroxisome proliferator-activated receptor gamma (PPARg): Leptin-deficient ob/ob mouse model studies to assess the effect of probe candidate on fasting blood glucose

Gene RIF (1851)

PMID Text
27078877 our findings reveal a key role for PPARgamma in neurogenesis and in the pathophysiology of human cytomegalovirus congenital infection
26966066 We conclude that under OGD condition, PEDF and 44mer reduce H9c2 cells apoptosis and inhibit OGD-induced oxidative stress via its receptor PEDF-R and the PPARgamma signaling pathway.
26956036 PPARgamma might inhibit the proliferation and migration of GC cell lines through suppressing the expression of TERT and ENAH
26869517 These observations indicate that troglitazone not only promotes growth, also the survival of RPT cells under conditions of hypoxia.
26782582 The PPARG SNPs rs6802898 and rs12633551 were significantly associated with the prevalence of hypertension in the Han and Mongolian populations, respectively.
26775637 cPGI2 activates PPARalpha and PPARgamma, which act separately from IP-R to up-regulate the expression of key genes involved in the function of brite adipocytes.
26721185 PPAR gamma inhibits the basal and LPS-induced expression of HMGB1 through upregulation of miR-142-3p, which can target the 3'-UTR of HMGB1, by directly binding to the PPRE in the miR-142-3p promoter region.
26673968 No association was found between PPARdelta T294C single nucleotide polymorphisms with obesity and metabolic syndrome in a multi-ethnic population in Kampar, Malaysia.
26671025 PPARgamma 12Pro/Ala resulting in an amino acid exchange in N-terminal sequence may be an independent protective factor for ischemic stroke in the Chinese Han population.
26631736 PPARgamma protein was increased in umbilical cord MSCs from obese mothers compared to cord MSCs from normal weight mothers.
26617799 Quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPARgamma and ABCA1.
26549231 Taken together, our results indicate that 24-MCF treatment increases parvin-beta expression, which may inhibit ILK downstream signaling.
26522807 C18:1 primed a pro-resolving macrophage which was PPARgamma dependent and ceramide dependent
26518621 SNPs within PPARgamma motifs that bind PPARgamma in adipocytes are significantly associated with cardiometabolic disease and with the regulation of transcription in adipose.
26507929 Pioglitazone-mediated CXCR7 suppression and macrophage chemotaxis inhibition occur via activating peroxisome proliferator-activated receptor gamma. PPARgamma activation suppresses CXCR7 expression in human carotid atherosclerotic lesions.
26504087 these results demonstrate that an interaction between STAT1, p300, and peroxisome proliferator-activated receptor-gamma is required for 15(S)-HETE-induced CD36 expression, oxidized low density lipoprotein uptake, and foam cell formation
26481528 a ground state of PPARg activity is required for Neural Progenitor formation of human embryonic stem cells during early neural differentiation.
26475999 found a significant association between genotypes of variants in rs10865710 and rs1805192 with increased CardioVaccular Disease risk and a potential gene-gene interaction between rs1805192 and smoking.
26469385 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
26462859 Observed expression patterns of several TLR inhibitory proteins with a noticeable suppression in expression of two of these; PPARgamma and TOLLIP in both ulcerative colitis and Crohn's disease and in both active and inactive disease states.
26398698 PPARG translation was suppressed by miR-130a through the interaction with the 3'UTR of PPARG mRNA
26397063 the present study revealed that miR-27b is upregulated by HPV16 E7 to inhibit PPARg expression and promotes proliferation and invasion in cervical carcinoma cells.
26391061 These results suggested that BA inhibited IL-1beta-induced inflammation in cultured osteoarthritis chondrocytes by activating PPAR-gamma.
26385316 PPARG phosphorylation is the key regulatory mechanism of the inflammatory response in adipose tissue.
26376791 Antiproliferative and pro-apoptotic 6IL effects require the activation of PPARG. In addition, wound-healing assays show that 6IL is able to inhibit MCF-7 cell migration and that PPARG plays a role in this phenomenon
26361038 The Ala allele of the PPARx03B3; Pro12Ala polymorphism in healthy adults was associated with increased BMI under a dominant model of inheritance. [review and meta-analysis]
26355313 Aspartate aminotransferase activity in nonalcoholic fatty liver disease patients, Ala-allele carriers, was significantly higher on 55,5% (p=0,007) than in patients with Pro/Pro-genotype.
26333042 Changes in GSK3beta-Ser(9) phosphorylation in in vivo haemorrhagic shock models can be modeled in vitro, and this has identified a role for PPARgamma activation in the protective role of valproic acid
26299428 PPARgamma activation can activate PTEN expression, thereby suppressing the expression of MMP2 and hence inhibiting the invasion and metastasis of pancreatic cancer cells.
26273662 TCF7L2 rs10885409 C allele is a T2DM risk factor in Emiratis; this association is modulated by obesity status, but the Pro12Ala mutation in PPAR-gamma2 is not associated with T2DM risk in this population
26260846 These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
26238426 PPARgamma prevented NALP3 inflammasome formation and IL1beta production in HK2 cells stimulated by monosodium urate crystals
26227476 PPARgamma up-regulation of LAT1 and TAUT was through specificity protein 1 (Sp-1) while stimulation of LAT2 expression was via induction of gene transcription.
26227398 It plays a role in insulin sensitivity.
26225656 PPAR-gamma Pro12Ala polymorphism is associated with gastritis, peptic ulcer disease, and gastric cancer.
26185753 We propose that, in obese Mexican-Mestizos, the combination of alleles 482Ser in PPARGC1A and 12Pro in PPARG2 represents a reduced metabolic risk profile, even when the adiposity indexes are increased.
26176182 adiponectin (ApN) and proliferator-activated receptor gamma (PPARgamma) are increased in Graves' orbitopathy muscular cells and adipocytes
26140591 In human fat, motif-altering SNPs cause differential PPARgamma binding, provide a molecular mechanism for some expression quantitative trait loci, and are risk factors for dysmetabolic traits in genome-wide association studies.
26125935 Meta-analysis showed no association between Alzheimer's disease and the PPARgamma G allele in any of the study subjects with or without the APOE epsilon4 allele. (Meta-analysis)
26125830 We investigated the association between polymorphisms rs1801282 and rs3856806 of the PPARg gene and metabolic syndrome (MS) among Uyghurs and Kazakhs. PPARg polymorphisms differ between Uyghurs and Kazakhs from Xinjiang Province, China.
26119484 Data show that a heterozygous peroxisome proliferator activated receptor gamma (PPARG) mutation c.1040A>C was identified in all 5 patients of the family but not in unaffected controls.
26105050 GPR40 and PPARgamma can function as an integrated two-receptor signal transduction pathway, a finding with implications for rational antidiabetic drug development.
26098770 PPARgamma regulates miR-98 to modulate ET-1 expression and pulmonary endothelial cell proliferation in pulmonary hypertension.
26098621 Evidence that multiple PPARalpha/delta/gamma gene polymorphisms are individually associated with increased low-density lipoprotein-cholesterol, and that interactions, among these alleles result in additional increased risk suggesting that PPAR genes may contribute substantially to the risk of cardiovascular diseases and atherosclerosis.
26093984 Peroxisome proliferator-activated receptors (PPARs) play pivotal roles in maintenance of Chorionic NAD-dependent 15-hydroxy prostaglandin dehydrogenase (PGDH) expression in chorion during human pregnancy.
26049557 PPARg Pro12Ala polymorphism is a protective factor of colorectal cancer.
26048716 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
26045830 PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease
26036343 PAK1 overexpression and activation in inflammation and colitis-associated cancer promote NF-kappaB activity via suppression of PPARgamma in intestinal epithelial cells.
26025336 Infants born to mothers with Pro12 genotype have better neurodevelopmental outcomes at 18 months of age than Ala allele carriers.
26007326 Important regulatory roles of PPARG and VEGF in the vascular processes associated with diabetes and atherosclerosis.
25985799 data reveal that the transcription factor, PPARgamma, is a bona fide intracellular target for S1P and thus suggest that the S1P:PPARgamma:PGC1beta complex may be a useful target to manipulate neovascularization.
25974167 The PPARG2 Pro12Ala genotype modifies the associations of sedentary behavior and moderate-to-vigorous intensity physical activity with common measures of insulin sensitivity.
25954810 Phosphorylation alters collective motions within the PPARG-RXRA-DNA complex.
25948680 Maternal overnutrition induces LPL expression in trophoblasts by reducing the inhibitory effect of SIRT1 on PPARgamma.
25944662 Ligands-activated PPARgamma suppressed proliferation of ovarian cancer cells and this growth inhibition is mediated by upregulation of miR-125b. PPARgamma promoted the expression of miR-125b by binding to the response element in miR-125b gene promoter region.
25937083 Peroxisome proliferator-activated receptor gamma attenuates serotonin-induced pulmonary artery smooth muscle cell proliferation and apoptosis inhibition involving ERK1/2 pathway.
25928419 In a large sample of Caucasians the rs1801282 of the PPAR-gamma gene was associated with waist circumference in type 2 diabetes mellitus patients.
25920026 PPARgamma Pro12Ala variation may not be an independent risk of ischemic stroke in Chinese Uyghurs, which was inconsistent with Dutch and Korean populations
25905670 TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARgamma2.
25897794 FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages.
25896411 peroxisome proliferator-activated receptor gamma polymorphism was significantly associated with fasted serum lipid profile in individuals with angiographically defined coronary artery disease
25891367 Upregulated expression of PPARgamma increases the sensitivity of cancer cells to cisplatin.
25889595 This study found that among patients with type 2 diabetes, the PPARgamma2 Pro12Ala polymorphism is protective against progression of nephropathy and decay of renal function independent of major confounders.
25879043 cardiorespiratory fitness may modulate PPARG expression in childhood and adolescence, independently of the genetic background
25875529 Macrophage PPAR-gamma is central regulatory factor in the switch of macrophage phenotype from proinflammatory phenotype to wound healing phenotype.
25832497 meta-analysis of PPARgamma rs1801282/rs3856806 polymorphisms and atherosclerotic diseases [meta-analysis]
25827163 Findings show signi fi cant association related to blood glucose level in patients with Pro12Ala polymorphism and energy intake in those with C1431T and T1431T genotype suggesting that PPAR-G2 polymorphisms are associated with postmenopausal hypertension.
25824760 Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism could be a risk factor for gastric cancer.
25817041 OR1A1 activation suppresses hepatic triglyceride metabolism by modulating HES-1, PPARG, and mtGPAT expression.
25794775 Results show that high levels of PPARG nuclear protein expression in breast cancer cells are a marker of good prognosis in patients with ER-positive tumors.
25784779 GG genotype of Pro12Ala was significantly associated with ESRD among patients with non-diabetes-related ESRD. Pro12Ala and C161T polymorphisms were significant predictors of mortality in ESRD patients with DM.
25779847 treatment with Ang-(1-7) promoted cholesterol efflux in Ang II-treated THP-1 macrophages, partly through inactivation of p38 and JNK signaling and by inducing the expression of PPARg and LXRa.
25770052 There was no significant association between PPAR-gamma rs1801282 polymorphism and Alzheimer's disease risk.
25766531 These findings suggest that OA-NO2 attenuates OGD/R-induced apoptosis by inhibiting Bax translocation and activation and the subsequent mitochondria-dependent apoptotic cascade in a PPAR-g dependent manner.
25758678 PPARs involved in the pathogenesis of migraine.
25756178 Synuclein-gamma shares some, but not all, gene regulators with leptin and is a PPARgamma target in adipocytes but not dorsal root ganglia neurons.
25734982 4010B-30 increases hepatic ApoA-I gene expression to promote cholesterol efflux via activation of PPARgamma.
25708358 we examined PAX8-PPARgamma rearrangement in 24 follicular thyroid carcinoma samples from Japanese patients. The fusion gene was detected in only one of 24 follicular thyroid carcinomas (4%).
25704091 PPAR-gamma regulated collagen synthesis was through PPAR-gamma-miR-145-Smad3 axis in hypertrophic scar fibroblasts.
25686501 Palmitic acid increases Ppargamma and Klf6 & Klf9 gene expression and promotes triglyceride accumulation in HepG2 cells.
25675995 Endothelial peroxisome proliferator-activated receptor-gamma protects against thrombosis through a mechanism that involves downregulation of P-selectin expression and diminished P-selectin-mediated leukocyte-endothelial interactions.
25665591 The over-expression of PPARgamma in obese individual's PBMCs may have a critical role in relationship between obesity and bone loss.
25665401 Increases in vital capacity following creatine supplementation were significantly higher in carriers of PPARgamma Pro12Ala allele than in PPARgamma Pro12Pro genotype.
25661292 study shows in lung alveolar interstitial fibroblasts nicotine alters PPARgamma promoter methylation and levels of its down stream myogenic targets, dose-dependently and recruits the epigenetic modulators DNMT1 and MeCP2 to form a repressive complex within a specific PPARgamma promoter region
25659766 PPARG polymorphisms are not statistically significantly associated with stroke.
25645621 Report PPARdelta-mediated regulatory mechanism for ACSL4 expression in liver tissue and cultured hepatic cells.
25618030 CD1d acts as a cell surface receptor that recognizes and binds oxysterols and initializes a pathway connecting oxysterol binding to PPARgamma activation
25600616 Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARgamma/LXRalpha pathway in THP-1 macrophage-derived foam cells.
25595716 miR-130a could contribute to metabolic homeostasis by dual targeting PGC1a and PPARgamma simultaneously.
25595457 Activation of PPARG increases the expression of C6ORF105 in human macrophages and atherosclerotic lesions.
25592200 The present study demonstrated that PPARgamma activation inhibited ERalpha expression in ERalpha-positive endometrial carcinoma cell lines.
25592041 Suggest PPAR-gamma activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth.
25584717 Variation in PPARG, but not Pro12Ala, contributes to declining insulin sensitivity and concomitant deterioration in beta-cell function in Mexican Americans at risk for T2 diabetes mellitus.
25572230 There is a significant association between the PPARg polymorphism rs12629751 and susceptibility to knee OA in a southeast Chinese population.
25557278 PPARgamma plays a central role in the regulation of the ERK1/2-NF-kappaB-Nox4-H2O2 signaling axis in pulmonary artery smooth muscle cell proliferation.
25548431 Ulcerative colitis patients with high gene expression of PPAR-alpha and -gamma have a better response to medical treatment and a mild clinical course of the disease.
25534870 GDF11 inhibits the activity of the peroxisome proliferator-activated receptor gamma by promoting its SUMOylation.
25516156 Peroxisome proliferator-activated receptors alpha and gamma are linked with alcohol consumption in mice and withdrawal and dependence in humans
25502405 Studies suggest that proliferator-activated receptor-gamma2 (PPAR-gamma2) Pro12Ala polymorphism might be a risk factor for obesity susceptibility.
25496486 Abietic acid acts as a PPARalpha/gamma dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-kappaB and the MAPK/AP-1 pathway
25475254 The ability to modulate PPAR-gamma's activity using already available drugs makes it a tempting therapeutic target--{REVIEW}
25468312 Data suggest PPARG is up-regulated in intraocular fluid and vitreous humor in patients with proliferative diabetic retinopathy as compared to control subjects with idiopathic epiretinal membranes; levels of PPARG increase as clinical stage advances.
25460295 the lipodystrophy syndrome caused by mutation in the PPARgamma nuclear receptor - partial familial lipodystrophy (Review)
25449421 the interaction between IGFBP-3 and PPARgamma is important for the growth-inhibitory effect of PPARgamma ligands in human breast cancer cells
25436737 This review focus is on the emerging concept of PPARgamma as a regulator for skeletal metabolism and summarizes recent findings about one of the mechanisms on how PPARgamma is connected to the circadian-regulatory system, which involves nocturnin.
25422184 Single nucleotide polymorphisms in the PPARgamma gene is not associated with breast cancer.
25410618 findings suggest that hyperglycemia down-regulates PPARgamma expression and induces inflammatory and catabolic responses in human chondrocytes and diabetic mouse cartilages
25406242 Pro12Ala polymorphism is associated with TL homeostasis after 5 years follow-up in subjects at high cardiovascular risk. In addition, a higher adherence to the MeDiet pattern strengthens the prevention of telomere shortening among Ala carriers
25389293 Using cells stably expressing RXFP1, we found that relaxin regulation of PPARg activity requires accumulation of cAMP and subsequent activation of cAMP-dependent protein kinase (PKA).
25377300 Data suggest that exercise-associated PPARgamma signalling effects appear, at least in monocytes, to be mediated by increased generation of PPARgamma ligands via oxidation of lipoproteins.
25376908 An association was observed in patients with Berardinelli-Seip syndrome between the Pro12Ala polymorphism of the PPARgamma2 gene with higher lipid levels, suggesting a close relationship between these factors.
25370690 Inhibitors of miR-34a and miR-34c upregulate the expression of PPARgamma and downregulate the expression of alpha-SMA in human hepatic stellate cells.
25368164 PPARgamma2 physically associated with c-Abl and was phosphorylated on 2 Tyr residues in its regulatory activation function 1 domain. This positively regulates PPARgamma2 stability and adipogenesis. c-Abl binding to PPARgamma2 required the Pro12 residue.
25366759 PPARgamma gene polymorphisms rs3856806, rs12490265, rs1797912, and rs1175543 were associated with metabolic syndrome in Kazakh subjects.
25342491 Diet modulates the effects of the PPAR gamma polymorphism on body weight and severity of obesity.
25333975 Our results show that oxLDL suppresses EP3 expression by activation of PPAR-g and subsequent inhibition of NF-kappaB in macrophages.
25333644 PPARgamma promotes chemoresistance in Pancreatic cancer cells, indicating that PPARgamma may represent a novel therapeutic target for Pancreatic cancer.
25274455 This study suggests that the SNP rs1800592 in the UCP1 gene is associated with increased risk of PDR in the Chinese type 2 diabetes mellitus population.
25265984 No statistically significant differences in serum lipid levels were detected between different genotypes in C161T and C1431T polymorphisms of PPARG.
25264247 PPARgamma-induced metabolic changes result in a marked increase of reactive oxygen species (ROS) levels that lead to rapid hypophosphorylation of retinoblastoma protein (RB) and cell-cycle arrest.
25262148 The rs1801282 C>G variant in PPARgamma presented a significant association with decreased type 2 diabetes risk.
25249007 Increased adipose tissue (AT) TLE3 in subjects with type 2 diabetes and in AT from high fat diet and PPARgamma knockout mice suggest that TLE3 may play an adaptive regulatory role that improves AT function under decreased PPARgamma expression
25216344 PPARG gene variability may increase the risk of dyslipidemia.
25187315 Low expression of PPARgamma and high expression of TSLP in the duodenal mucosa of children with newly diagnosed Celiac disease suggest that they are involved in the pathophysiology of this disease
25182148 Our study indicates that PPARG rs1801282 may significantly predict overweight, BMI, and total cholesterol in female but not male Taiwanese subjects.
25170593 This study found no significant association between proliferator-activated receptor gamma-related SNPs and elite endurance athlete status in the Chinese population.
25159899 PPARgamma2 rs1801282 polymorphism may play a significant role in the development of metabolic disorders in HIV/HCV coinfected patients, and might have an influence on the cardiovascular risk.
25157153 Approximately 1 in 1,000 individuals carries a variant in PPARG that reduces function in a human adipocyte differentiation assay and is associated with a substantial risk of type 2 diabetes.
25122050 activation appears to be detrimental to kidney proximal tubular epithelium
25101957 PPARgamma is one of the targets of stress induced premature senescence in human dermal fibroblasts and its pharmacological up-modulation may represent a novel therapeutic approach for the photooxidative skin damage.
25096510 The Pro12Ala and C161T polymorphisms were associated with some important risk factors for cardiovascular disease in hemodialysis patients in the Han Chinese population.
25093444 A subset of PPAR(gamma)-binding sites for late-expressing genes such as Adiponectin and Adiponectin receptor2 were differentially methylated independently of the early program.
25080457 genetic association study in population of children in Denmark: Data suggest that 3 SNPs in fatty acid desaturase 1 are associated with developmental psychomotor disorders at 30 months of age; an SNP in PPARG (rs1801282) may also be involved.
25072612 The presence of PPARgamma2 rs1801282 G allele (Ala variant) was associated with increased odds for achieving sustained virological response in HIV/hepatitis C-coinfected patients on hepatitis C treatment.
25044948 Data suggest that induction of MCP1 (CCL2) expression in retinal pigment epithelium is involved in pathogenesis of macular degeneration; down-regulation of MCP1 expression via PPARgamma/NFkappaB pathway may prevent macular degeneration.
25025992 PPARgamma activator pioglitazone, added on calcium channel blockers significantly reduced coronary spasm.
25001926 Data indicate that peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist 15d-PGJ2 could inhibit chemokines production induced by IFN-gamma combined with TNF-alpha in HK-2 cells.
24984871 Our results suggest that that the Ala allele might be a protective factor against acne development or may attenuate acne severity.
24976296 PPARG inhibits cell invasion, migration and epithelial-mesenchymal transition through upregulation of galectin-9 in vitro and in vivo.
24969838 Significant associations were observed between neonate ethnicity and PPARG2 (p = 0.005) and FTO (p = 0.017) variants: high-risk alleles were more prevalent among African than South Asian neonates for both variants
24928385 atherosclerotic lesions of both mice and human compared with healthy counterparts. Here, we observed that Mfn2 increased cellular cholesterol transporter expression in macrophages by upregulating peroxisome proliferator-activated receptor-gamma
24922638 High PPARgamma is associated with gastric cancer progression.
24882418 NSAID use was significantly associated with decreased cancer risk regardless of PPARgamma rs1801282 genotypes.
24880474 PPARA and PPARG polymorphisms should be involved in the regulation of plasma Lp(a) independently and/or in an interactive manner.
24850609 Effect of single nucleotide polymorphism Pro12Ala of PPARgamma2 gene in obese children on the predisposition to the metabolic syndrome.
24850604 12Ala polymorphism of PPAR-gamma2 gene determines severity of bronchial asthma course associated with coronary heart disease.
24841086 PPARgamma C161T polymorphism may reduce risk of ischemic stroke in patients with type 2 diabetes mellitus.
24839816 Development of type 2 diabetes and diabetic nephropathy are both associated with PPARgamma2 Pro12Ala gene polymorphism.
24814410 7-ketocholesteryl-9-carboxynonanoate is a novel PPARgamma agonist, promoting ApoA-I-mediated cholesterol efflux from THP-1 macrophages by increasing ABCA1 expression via induction of PPARgamma.
24798894 In this series, PAX8/PPARgamma rearrangement found in thyroid nodules had a 100% predictive value for differentiated thyroid cancer
24779289 Interplay of PPARgamma C161T polymorphism, gender, and high-carbohydrate diet can change not only the ratios of plasma lipids and apolipoproteins but also the association of the ratios with plasma glucose, waist circumference, and body mass index.
24769306 In non-diabetic patients with hypertension or hypercholesterolemia, PPAR gamma agonist pioglitazone does not affect endothelin-1 activity.
24751522 PPARgamma negatively regulates the expression of miR-613 at transcriptional level, and miR-613 suppressed LXRalpha and ABCA1 by targeting the 3'-UTR of their mRNAs.
24735796 We elucidated the molecular mechanisms by which PPARgamma mediates the anticancer activity of cladosporol A.
24708348 PPAR-gamma inhibition during osteogenic induction leads to a significant up-regulation of a number of genes related to both osteogenesis and adipogenesis
24697566 meta-analysis demonstrates that the PPARgamma Pro12Ala polymorphism is associated with susceptibility to NAFLD in East Asians, but not in European populations
24642720 Suggest the radiosensitizing effects of PPARgamma inhibitor T0070907 occur through G2/M arrest and mitotic catastrophe.
24642257 Transgenic over-expression of PPARG2 induced browning in subcutaneous fat.
24623782 We therefore tested whether PPARgamma and ERK associated in protein complexes that subserve cognitive enhancement through PPARgamma agonism.
24612564 Despite the known biological significance of the PPARG gene and a sufficient statistical power of the present study, we could not replicate the association of PPARG with T2DM in our high-risk population.
24604522 PPARgamma and RXR ligands were investigated for their capability to interference with the cross-talk between breast cancer stem cells and the niche compartment.
24576555 PPARgamma is a main factor in the protocatechuic acid-induced effects as blocking its activity abolish protocatechuic acid capacity to down-regulate IL-6 and IL-8, but not CCL2, secretion and to inhibit monocyte-derived-dendritic cell migration.
24569375 Reduced PPARG activity promotes smoking induced emphysema.
24519403 Treatment with a PPARgamma agonist in non-diabetic patients results in a coronary artery plaque stabilization on top of usual medical care.
24510380 PPARG rearrangement is associated with thyroid neoplasm.
24486703 Homocysteine-induced expression of p22(phox) is regulated by the reactive oxygen species/p38MAPK pathway and PPARdelta activation is capable of attenuating this pathway by eliminating Hcy-induced reactive oxygen species production.
24477323 meta-analysis identified an association between Alzheimer's disease(AD)and the COMT Val158Met polymorphism in Asians but not in Europeans, but it revealed no association between AD and the PPARgamma Pro12Ala polymorphism
24467636 The dual PPARalpha/gamma agonist aleglitazar increased migration/proliferation of endothelial progenitor cells from coronary artety disease patients.
24464185 the PPARgamma C1431T polymorphism is related to an increased risk of MetS in an Iranian population and interacts with the Pro12Ala polymorphism, further increasing the risk of MetS.
24460649 PPAR-alpha and PPAR-gamma polymorphisms and haplotypes may be the genetic risk factors for dyslipidemia.
24447396 findings show PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa
24440556 PPARgamma1 phosphorylation is a critical event in human fibrosarcoma growth.
24431460 Hippocampal cognitive enhancement via PPARgamma activation occurs through regulation of presynaptic vesicular proteins critical for proper glutamatergic neurotransmitter release, synaptic transmission, and short-term plasticity in ADD Alzheimer's model mice.
24401602 Our results suggest a role of PPARG gene in the development of systemic sclerosis
24379269 This review summarizes the current literature on a functional relationship of PPARgamma with obesity and insulin resistance and, moreover, highlights the significance of synthetic ligands of these receptors in the mentioned metabolic disorders.
24374034 a highly positive correlation between PPARgamma expression and HIF-1alpha expression
24371122 Data show the essential role of PPARgamma and PPARgamma coactivator 1alpha (PGC-1alpha) in up-regulating Insig-1/2 expression, defining a mechanistic pathway triggered by CD36, and leading to cholesterol depletion in hepatocytes.
24359430 These data demonstrated that HIV permissiveness is associated with a superior state of cellular activation and limited antiviral properties and identified PPARgamma as an intrinsic negative regulator of viral replication.
24343628 PPARG 12Ala-carriers (rs1801282) presented higher glucose levels than Pro/Pro homozygotes.
24338223 RG inhibits the migration and adhesion of HMC-1 cells by a PPARgamma-dependent mechanism.
24333565 The findings of this study demonstrated that PGD2 produced by H-PGDS and acting on DP1R is essential for seizure suppression and that the L-PGDS/PGD2/DP1R system regulates sleep that follows seizures.
24332944 In patients with TGCV, even when hydrolysis of intracellular TG is defective, the marked up-regulation of PPARgamma and related genes may lead to increased uptake of LCFAs, the substrates for TG synthesis.
24329532 In conclusion, the PPARgamma Pro/Pro genotype was associated with T2DN risk in Caucasians, but the Ala/Ala genotype and Ala allele not.
24319114 found that the FABP4 level was higher and PPARgamma level was lower in human visceral fat and mouse epididymal fat compared with their subcutaneous fat
24308220 According to obtained results LPL and PPARG gene variants could be susceptibility factors of obesity and lipid status, contributing to development of metabolic syndrome, particularly in males.
24307415 transcriptional changes were consistent with the negative regulation of peroxisome proliferator-activated receptor gamma (PPARgamma) at high altitude; such effects were accompanied by reduced birth weight and head circumference at high altitude vs. sea level
24303936 PPARgamma Pro12Ala gene polymorphism is not associated with type 2 diabetic nephropathy.
24292674 PPARgamma induces MUC1-C ubiquitination and degradation that is critical to terminate MUC1-C signaling pathway-elicited cancer
24288364 The combination of PPAR-gamma agonist rosuvastatin with telmisartan increased the possibly antiatherosclerotic HDL-Lp-PLA2 activity.
24265769 LOX, LOXL1 and LOXL2 are downstream PPARgamma targets and that LOX activity is a negative regulator of trophoblastic cell invasion
24260304 RGL activates PPARgamma SUMOylation.
24252844 The peroxisome proliferator activated receptor-gamma pioglitazone significantly improves aortic elasticity and decreases inflammation and disease activity with minimal safety issues in rheumatoid arthritis.
24247152 Tbx20 regulated PPAR-gamma expression and protected the vascular endothelial cells from oxidized low-density lipoprotein -induced injury.
24243083 We suggest that the haplotype composed of the C/C genotype carriers with an Ala allele of PPARgamma2 group enhances susceptibility to the metabolic syndrome in a central Tunisian population.
24219556 Results suggest PPAR-gamma to be involved in the regulation of ESE-3b expression during monocyte-derived dendritic cells (moDCs) development and that ESE-3 expression is not correlated with the immunogenicity of dendritic cells (DCs).
24190593 reduced PPARgamma expression in gestational diabetes mellitus placentas may be due to an altered concentration of fatty acid derivates
24189640 Both C-FABP and PPARg are suitable as prognostic factors to predict the clinical outcome of prostatic cancer patients.
24169559 11beta-HSD2 expression can be modulated by PPARalpha and PPARgamma in placental trophoblasts through Sp-1
24141935 This meta-analysis supported the fact that the G allele of PPARgamma2 Pro12Ala (rs1801282) modestly affects the risk of breast cancer.
24133572 novel biomarkers in colorectal cancer activated through PPARgamma and TNFalpha signaling
24129064 endogenous ligand-activated PPARgamma signaling is important in human sebocyte biology, including differentiation and lipid production
24126791 the present study demonstrated that both ERa and ERbeta were sufficient to inhibit PPARgama and provide a valuable therapeutic option for the treatment of Hepatocellular carcinoma patients.
24107916 Here we give a review of how PPARgamma and its ligands regulate tumorigenesis by different pathways. [review]
24107399 Pleiotropic effects of peroxisome proliferator-activated receptor gamma and delta in vascular diseases. [review]
24072712 the stability and activity of PPARgamma2 are modulated by the deubiquitinating activity of HAUSP, which may be a target for the development of anti-diabetic drugs.
24064359 These results indicate that PGE2 receptors EP2 and EP4 mediate actions of PPARgamma by incorporating multiple cell signaling pathways.
24050824 there might be inter- or overlapping actions between PPARg and RARs, and there might be an association of PPARg/RARs with renal diseases.
24040456 In polycystic ovary syndrome PPAR-gamma Pro12Ala polymorphism may modulate the concentrations of serum fasting TG levels and fat-deposition in abdomen.
24032744 PPARgamma agonists elevate PTEN expression in a resistant/ABCG2-overexpressing cells, which inhibits the PI3K-Akt pathway leading to relocalization of ABCG2 from the plasma membrane to the cytoplasma, circumventing the ABCG2-mediated MDR.
24027433 Since higher levels of miR-130b are found in advanced tumor stages (III-IV), we propose a novel role of the miR-130b-PPARgamma axis in fostering the progression toward more invasive colorectal cancers.
24021801 PPAR gamma as a potential CSF biomarker of multiple sclerosis.
24012868 This meta-analysis suggested that the effect of Pro12Ala polymorphism in PPARgamma2 gene may not be related to metabolic syndrome as an entity. However, Pro12Ala may affect the single component of metabolic syndrome
23991018 results suggested that the presence of the Ala allele in PPARgamma2 gene may contribute to improved insulin secretory capacity and may confer protection from type 2 diabetes and obesity in the Chinese population.
23990052 Following induction of PPARgamma expression, pim-1 kinase is upregulated in vascular endothelial cells.
23943160 modulates endometrial cancer cell survival
23939428 the expression of cytoplasmic PPARgamma was positively related with Skp2 expression and correlated significantly with estrogen receptor & pathological grade
23937351 Transient suppression of PPARgamma promotes the onset of osteogenesis.
23909657 the Pro12Ala polymorphism of the PPARgamma gene might be an independent factor in BMD level and osteopenia in thalassemia patients.
23891824 A lower prevalence of 12Ala allele of gene PPARgamma was found in the non-alcoholic steatohepatitis subgroup when compared to control Group.
23891820 The PPARG Pro12Ala polymorphism is not associated with non-alcoholic fatty liver disease risk. [Meta-analysis]
23887394 Data indicate that 15-deoxy-delta(12,14)PGJ2 inhibits chemokines MCP-1 and IL-8 expression via a PPAR-gamma-independent way, which is related to block NF-kappaB pathway.
23884832 The gene expression profiling results showed that TNFAIP3, ATF3, PPARG are related to osteoarthritis.
23881602 stimulation of PPAR-gamma promotes the maturation of human cord blood CD133 positive precursors into efficient, immunostimulating dendritic cells with a Langerhans cell phenotype.
23866026 PPARgamma and PPARGC1B polymorphisms modulate the association between phthalate exposure and BC risk
23856170 Review/Meta-analysis: Pro12Ala polymorphism in PPARgamma2 gene is not a risk factor for diabetic nephropathy in type 2 diabetes.
23848091 Increased body mass and visceral adiposity were associated with worse glucose metabolism suggesting metabolic differences between morbid obese with Pro12Pro genotype
23833249 all three proteins (RDH10, RALDH2, and CRABP2) appeared to be required for ATRA production induced by activation of PPARgamma
23811234 PPARs play a role in placental nitric oxide (NO) and lipid homeostasis and can regulate NO production, lipid concentrations and lipoperoxidation in placentas from type 2 diabetic patients.
23803735 PPARgamma-induced SOCS3 expression represses Th17 cell differentiation.
23799144 The PPARG 12Ala allele may be a relevant genetic factor favouring strength abilities in professional athletes.
23776688 Accumulation of advanced glycation end products induce PPARgamma down-regulation-mediated inflammatory signalings and reduction of collagen II expression in human osteoarthritic chondrocytes.
23770845 PPARgamma pathway is critical for the cancer stem cell properties of ERBB2-positive breast cancer cells.
23748472 This is the first report to establish that variations in PPARgamma gene influence the insulin resistance pathophysiology in Indian women with polycystic ovary syndrome.
23738683 There was no correlation between the extent of capsular or vascular invasion and PAX8-PPARgamma translocation, or between lymph node or haematogenous metastasis and PAX8-PPARgamma translocation in thyroid carcinomas.
23736812 DNA from 4 HPV positive and 4 HPV negative fresh frozen primary HNSCC were subject to comprehensive genome-wide methylation profiling.Pathway analysis of 1168 methylated genes showed 8 signal transduction pathways (PPARG) of which 62% are hypermethylated.
23716627 PPAR-beta/delta activation exacerbates, and its inhibition reduces, preretinal neovascularization. PPAR-beta/delta may regulate preretinal neovascularization through a prodifferentiation/maturation mechanism that depends on Angptl4.
23711995 PPARalpha and PPARgamma up-regulate the expression of human MBL2 via the peroxisome proliferator response element.
23703729 role of the PPARgamma binding complex for epigenetic regulation of miR-122 in human hepatocellular carcinoma cells.
23684777 These results also indicate that restoration of PPARgamma activity with pharmacological ligands may provide a novel therapeutic approach in selected forms of Pulmonary hypertension .
23652783 The polymorphisms of C681G and intron CT were significantly associated with the risk of EH, and the GC, CT, and GT haplotypes established by C681G and intron CT are likely to be genetic markers of EH in the Han Chinese population.
23652363 The Ala 12 Ala genotype of the PPARgamma2 gene may decrease the number of diseased vessels and the severity of coronary artery disease.
23647960 Hypermethylation of CpG islands in peroxisome proliferator-activated receptor gamma gene promoter is related with liver fibrosis progression.
23640498 Increasing ceramide levels in the liver can be achieved by SMS2 inhibition to prevent liver steatosis via PPARgamma suppression.
23636469 Chronic consumption of a high-advanced glycation end products diet depletes defenses such as SIRT1 and PPARG.
23633103 Suggest that Pro12Ala (rs1801282), a coding variant in the PPARG gene, is associated with rheumatoid arthritis in Pakistanis.
23612072 the antitumor effects of 6-shogaol are mediated through activation of PPARgamma
23604462 The gain-of-function Ala(1)(2) variant protects against Graves' ophthalmopathy and modulates the course of the disease.
23593291 PPAR delta attenuates colon carcinogenesis
23583560 SOX9, beta-catenin and PPARgamma expression levels are deregulated in the CRC tissue.
23583468 The increasing effect of the PPARA-V162 allele on serum total-cholesterol and LDL-cholesterol levels was weakened with the presence of PPARG-161T allele in the non-diabetic coronary heart disease patients.
23574724 PPARgamma activation in stromal cells results in the formation of a catabolic pro-inflammatory microenvironment that metabolically supports cancer growth.
23562554 Upregulation of FAM3A by PPARgamma activation is correlated with increased pAkt level in liver cells.
23559865 A protective role of the 12Ala polymorphism against proliferative diabetic retinopathy in individuals with type 2 diabetes mellitus in Pakistan, is reported.
23555077 PPAR agonists treatment induced the deactivation of cPLA2-COX-2-prostaglandins pathway together with an increase in TLR4 expression, all of whose criteria meet the M1 macrophage profile
23549616 The PPARgamma interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif.
23545576 rs2016520 and rs10865170 were associated with lower obesity risk. In addition, interaction was identified among rs2016520, rs9794, and rs10865170 in obesity.
23542179 Which serves as an endogenous PPARgamma ligand.
23531513 Inhibition of PPARgamma-dependent gene expression during monocyte differentiation may contribute to an AICAR-elicited macrophage phenotype characterized by reduced inflammatory responses to modified lipoproteins and saturated fatty acids.
23530462 PPARgamma polymorphisms and haplotypes were significantly associated with hypertension susceptibility.
23525438 Identify a novel role for capillary endothelial PPARgamma as a regulator of fatty acid handing in FA-metabolizing organs including the heart in the postprandial state after long-term fasting.
23516550 the effects of PSF on cell proliferation, tumor growth, and cell signaling associated with PPARgamma
23514940 downregulation of PPAR-gamma is a possible mechanism that leads to the clinical drug resistance of cancer
23502212 Results identified the ligand-binding domain in peroxisome proliferator-activated receptors (PPARs) alpha and gamma.
23483194 PPARgamma agonists induce vasorelaxation in pulmonary arteries and is partially endothelium-dependent.
23461356 These findings suggest that PPARgamma activation inhibits hepatocellular carcinoma cell invasion via the upregulation of PAI-1
23448101 PPARgamma2 gene Pro12Ala polymorphism is not associated with nonalcoholic fatty liver disease
23438152 The reference genotype of PPARgamma Pro12Ala seems to favor a better lipid profile, while the variant allele decreases blood pressure.
23436219 Results provide the first demonstration of PAX8/PPARgamma rearrangements in post-Chernobyl tumors and show different associations for point mutations and chromosomal rearrangements with (131) I dose and other factors.
23426382 None of the SNPs in the PPAR-gamma gene showed a statistically significant effect either on steady-state concentrations or on the therapeutic response to rosiglitazone
23424659 a key role of PPARgamma in regulating pancreatic beta-cell function by improving the stability of Pdx1 and Mafa proteins
23418723 Data suggest that PPARG can be induced by dietary components (here, tomato extract, polyphenols, and isoprenoids).
23417417 Studies suggest that adipokines, AMPK, PI3K and the PPAR signaling pathways could be targets of therapeutic strategies for the ovarian cancers and reproductive pathologies.
23393388 Report novel PPAR-gamma mutations that may contribute to familial partial lipodystrophy-linked severe hypertension.
23386649 The association between PPARG Pro12Ala single nucleotide polymorphism and increased type 2 diabetes susceptibility was confirmed, with Pro12 as risk allele.
23370527 Data suggest that EGFR (epidermal growth factor receptor) activation mediates PPARG-induced sodium and water reabsorption via upregulation of NHE3 (sodium/hydrogen exchanger 3) and AQP1 (aquaporin 1) in proximal tubules.
23364967 Polymorphisms in PPARgamma(2) and IGF2BP2 were shown to be highly correlated with GDM occurrence, whereas no correlation was found for KCNQ1 polymorphisms.
23339868 Consistent with the notion that fermentation leads to PPAR activation in vivo.
23333304 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
23320500 the phosphatase PPM1B as a novel selective modulator of PPARgamma activity.
23317272 PPARgammaPro12Ala G (Ala12) allele might be associated with development, differentiation and metastatic process of gastric cancer.
23315125 The PPARgamma Pro12Ala variant may contribute to the observed variability in PPARgamma mRNA expression and consequently in body mass index and insulin sensitivity in the general population.
23300871 Our results demonstrated that the PPARgamma2 Pro12Ala polymorphism might be risk-conferring locus for the progression of coronary artery disease among Caucasians, but not among Asians.
23275339 up-regulation of KLF4 upon PPARgamma activation is mediated through the PPRE in the KLF4 promoter
23273766 Findings support the hypothesis that the single nucleotide polymorphisms (SNPs) from PPARdelta/PPARgamma genes contribute to the risk of abdominal obesity independently or in an interactive manner.
23266668 our results revealed the PPARgamma C161T polymorphism might play a moderate protective effect on developing CAD among Chinese, but not among Caucasians
23262340 PPAR-alpha, PPAR-delta and PPAR-gamma polymorphisms may contribute to the risk of hypertriglyceridemia independently and/or in an interactive manner.
23256116 Common PPARgamma variants C161T and Pro12Ala are not associated with inflammatory bowel disease in an Australian cohort
23254958 Treatment of breast cancer cells with PPAR-gamma agonists elevated the expression of leptin and VEGF mRNA and protein, and increased cell viability and migration.
23250430 acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation
23239344 up-regulates the levels of CCAAT/enhancer binding protein alpha (C/EBPalpha) and PPARgamma and promotes adipogenic differentiation starting from the early stage of adipogenesis.
23237621 the PPARgamma gene appeared good biomarkers in hyperuricemia; therefore, these powerful indicators may be included in the prediction of hyperuricemia to increase the accuracy of the analysis.
23223023 These data provide first insights on how mechanistically palmitic acid drives endothelial progenitor cell and bone marrow-derived hematopoietic cell dysfunction in diabetes.
23220503 A novel proapoptotic mechanism of cannabidiol involving initial upregulation of COX-2 and PPAR-gamma nuclear translocation of PPAR-gamm by COX-2-dependent prostaglandins.
23219716 These data also implicate PPARgamma and PTEN inactivation in the development of keratinizing squamous metaplasia.
23212831 CITED2 is a direct effector of PPARgamma for tumor suppression.
23202735 CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARgamma signaling.
23168911 Omega-3 ethanolamides exert anti-proliferative effects by inducing autophagy in breast cancer cells via PPAR-gamma activation.
23161442 PPARG2 and ADAMTS9 variants are both associated with type 2 diabetes mellitus and with insulin resistance, whereas only ADAMTS9 may be related to beta cell function.
23147557 Diabetes risk alleles in PPARG2(rs1801282) and PTPRD (rs17584499) are associated with pioglitazone therapeutic efficacy.
23145084 The impacts of PPARgamma C1431T and Pro12Ala polymorphisms on metabolism in HIV-infected patients are not significant
23142027 ZNF395 coordinate the transcriptional regulatory pathway with PPARG2, which may be necessary for the genesis of adipocytes.
23130662 Glycolytic enzymes PGK1 and PKM2 are novel transcriptional targets of PPARgamma in breast cancer.
23118933 PU.1 sites may have served as anchor loci for the formation of new and functionally relevant PPARG binding sites throughout evolution.
23113754 study found cardiovascular disease risk factors in postmenopausal women are not directly associated with the polymorphisms of peroxisome proliferator-activated receptor gamma 2 and adrenoceptor beta 3 genes
23107193 PPARg polymorphism was not independently associated with periodontitis or bone mineral density. However, the polymorphism might be a modulator of the relationship between the two conditions in postmenopausal Japanese women
23096090 Amerindians show no association of PPAR-gamma2 gene Ala12 allele and obesity.
23088980 PPARG is involved in the antitumor action of bacillus Calmette-Guerin.
23084144 We propose that aging of the meibomian gland results in downregulation of PPARgamma, leading to decreased meibocyte differentiation and lipid synthesis, gland atrophy, and a hyposecretory meibomian gland dysfunction.
23065280 The Pro12Ala, C161T and C1431T polymorphisms of PPARG gene are not associated with coronary heart disease susceptibility. [Meta-analysis]
23064015 incorporation of the histone variant H2A.Z at the promoter regions of PPARgamma target genes by p400/Brd8 is essential to allow fat cell differentiation
23060450 Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-gamma.
23054024 An overall weak association between the P12A polymorphism and gestational diabetes mellitus risk among East Asians. [Meta-analysis]
23036713 data suggest that insulin resistance is associated with low adipose LPL activity independently of obesity, but the PPARgamma2 Pro12Ala polymorphism seems to protect the LPL functioning of obese insulin resistant women
23036708 While we have detected significant difference in allelic frequencies of PPARgamma2 C (Proline) and G (Alanine), but at genotypic level significant difference was not detected in this case-control study
23031808 Asian Indians in north India carrying the alleles Ala and T of PPARgamma (Pro12Ala and C161T) polymorphisms are predisposed to develop non-alcoholic fatty liver (NAFLD).
23006958 Although PPARG2 Pro12Ala polymorphism might attenuate associations between known risk factors and HbA1c level, it had a small effect on high-normal HbA1c, as compared with clinical risk factors, in the general population.
22993484 A significant association exists between the Pro12Ala polymorphism and diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) in Caucasians but not in Asians. The Ala allele has a significant protective effect against DR in T2DM.
22993124 To date, at least 15 convincing T2D loci have been identified from large-scale genome-wide association studies and meta-analyses in East Asians
22992727 Data indicate that the antitumor effects of isorhamnetin may be mediated through modulation of the PPAR-gamma activation pathway in gastaric cancer (GC).
22987045 A meta-analysis suggests that the PPARG C161T polymorphism marginally contributes to increased susceptibility to coronary heart disease (CHD) and marginally increased association between PPARG H477H polymorphism and CHD also appeared in Asian and hospital-based controls.
22985084 frequency of the PPARG Pro/Ala genotype was significantly higher in sample of male subjects who died before 90 years of age than in the long-lived, suggesting that carrying the PPARG Pro/Ala genotype may prevent the attainment of advanced age only in men
22961909 pathogenic role played by PAX8-PPARG fusion genes in thyroid tumorigenesis.
22954708 The induction of three enzymes whose activity can potentially generate endogenous PPARgamma ligands in an IL-4 dependent manner.
22949934 Telmisartan attenuated TGF-beta1 induced epithelial-to-mesenchymal transition by agonistic activation of PPAR-gamma.
22944052 There is an interaction between PPARA, PPARD and PPARG SNPs on the incidence of abdominal obesity.
22940187 The changes in PPARgamma and PPARalpha expression are associated with the steatosis and the impairment of antioxidant system in the liver of Wilson's disease patients.
22934513 Knocking down PPARG decreased cell proliferation and increased apoptosis of PC3 prostate cancer cells.
22910911 PPARgamma displays increased responsiveness in cultured hSOD1(G93A) motor neurons, points to a role for this receptor in neutralizing deleterious lipoperoxidation derivatives within the motor cells.
22884583 Abrogation of PPARgamma's AF2 domain attenuated its repressive action on 1,25D(3) transactivation, indicating that this domain is integral in inhibiting VDR signaling.
22871496 High PPARgamma expression is associated with ovarian granulosa cell tumor.
22860094 lower PPARgamma and PON2 gene expression in the BALF of children with CF is associated specifically with P. aeruginosa infection and neutrophilia
22853971 Our study suggests that PPARgamma is a piece of the puzzle that links psoriasis to the metabolic syndrome.
22843934 study provides the basis for applying PPAR-gamma ligands clinically in treatment of advanced prostate cancer
22843091 These results indicate the reciprocal relationship between NR0B1 and PPARgamma on the malignant grade of lung adenocarcinoma
22840054 HMW-Hyaluronan (HA) and oligo-HA exerted differential inflammatory responses via PPARgamma in IL-1beta-treated chondrosarcoma cells.
22820754 This study has revealed that the G allele of rs10865710 in the PPAR-gamma gene is associated with the increased susceptibility to non-alcoholic fatty liver disease.
22819264 Therefore, we envision that the antithrombotic activity of CORM-2 might be used as a pharmaceutical agent for the treatment of various inflammatory conditions.
22814748 Data are consistent with peroxisome proliferator-activated receptor-delta being a potentially important target for providing cardiovascular protection in metabolic syndrome-like patients.
22800638 PPARgamma2 Pro12Ala polymorphism was not associated with type 2 diabetes mellitus in a Chinese Han population. [meta-analysis]
22766852 These results support the hypothesis that PPARgamma stimulates MUC1 expression by AGS cells, thereby attenuating H. pylori- and PMA-induced IL-8 production.
22750678 the role of PPARgamma in controlling homeostasis of multiple systems beyond lipid metabolism in partial lipodystrophy
22739234 DHI could significantly reduce ox-LDL-induced expressions of mature markers.
22729915 The PPARgamma Pro12Ala polymorphism did not significantly associate with polycystic ovary syndrome. [Meta-analysis]
22724641 [review] PPARgamma contributes to variance in body mass index and influences the variance in appetite factors such as measured energy intake, satiety responsiveness and the intake of palatable energy-dense food.
22716961 Data suggest that PPARgamma expression and transport to cell nucleus can be up-regulated by genistein, a dietary antioxidant; activation of PPARgamma appears an important factor in protection against oxidative stress by genistein.
22694222 The Ala/Ala genotype of the PPAR-gamma2 gene is associated with obesity and insulin resistance in Asian Indians without diabetes living in north India.
22689692 PPARgamma expression was found to be low in placentas of born small fetuses and to associate positively to fetal and placental weights within this subpopulation.
22685582 Data indicate that the agonists not only possessed the same function as GW409544 did in activating PPAR-alpha and PPAR-gamma, but also had more favorable conformation for binding to the two receptors.
22684020 Suppression of KEAP1 in lung tumor cells resulted in increased expression of PPARgamma and was accompanied by induction of cell differentiation markers andattenuated expression of cancer stem cell markers.
22664386 Delta(12)-PGJ(2) is a dominant metabolite of L-PGDS-produced PGD(2) during adipogenesis and acts as an activator for adipogenesis through both PPARgamma-dependent and -independent mechanisms
22653647 PPARg2 Pro12Ala polymorphisms are associated with increased risk for myocardial infarction in Han Chinese in Hohhot.
22651256 analysis of regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-gamma in human adipose tissue
22647601 observations indicate that human T cells exhibit a sex difference in the production of IFNgamma and IL-17A that may be driven by expressions of PPARalpha and PPARgamma
22619290 Our results indicated that the Ala12 variant is a significantly protective factor for DN. Future research should focus on the effect of Pro12Ala polymorphism on ESRD and gathering data of Africans.
22584573 GQ-16, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, promotes insulin sensitization without weight gain.
22583414 The present review summarizes the available information on PPARG expression in breast tumors and the use of PPARG ligands as anti-cancer agents for breast cancer treatment.[review]
22575725 The study suggested that while IRS-1, contrary to the earlier findings in other ethnic groups, has a protective role against development of polycystic ovarian syndrome. The protective role of PPAR-gamma was reaffirmed.
22573555 proposed that Syncytin-1 is regulated by PPARgamma/RXRalpha signaling during placentogenesis to drive multinuclear syncytiotrophoblast layer formation and maintenance.
22564702 A significant association between PPAR-gamma2 Pro12Ala polymorphism and reduced risk of polycystic ovarian syndrome was observed. Stratified analysis showed that a significantly strong association was present only in Europeans and not in Asians.
22561695 A meta-analysis was performed to assess the association of PPARgamma2 rs1801282 polymorphism with hypertension risk.
22558273 The binding of STAT-1 to specific responsive elements in the promoter of PPARgamma and FXR and MCP-1 shifts macrophages toward a pro-atherogenetic phenotype.
22558273 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
22544925 Mycobacterium tuberculosis interacts with macrophage lipids and human host PPARgamma to ensure survival of the pathogen by modulating macrophage function.
22537818 LEP, LEPR and PPARgamma may play a role in the onset and cessation of menstruation, and the total duration of menstruation
22527903 findings show Ala variant would decrease the risk of polycystic ovary syndrome (PCOS) and result in lower body mass index and fast insulin levels in a European population, but had no impact on homeostasis model assessment of insulin resistance in PCOS patients
22525341 Inhibition of epoxide hydrolase positively modulated the functions of endothelial progenitor cells in patients with acute myocardial infarction through PPARgamma.
22519881 Activation of PPARgamma counteracts angiotensin II-induced ROS generation by inhibiting rac1 translocation in vascular smooth muscle cells.
22515931 The PPARG Pro12 risk allele contributed to increased risk for both T2 diabetes and coronary heart disease.
22489460 HCV core protein expression-mediated FOXO1 activation and the increased PGC-1alpha leaded to the elevation of PCK1 at the mRNA level
22487967 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
22475777 Study suggested that the variant genotypes in PPAR-gamma gene could increase the risk of MetS; however, genotypes in RXR-alpha gene could decrease the risk of MetS in a Chinese Han population.
22456356 peroxisome proliferator-activated receptor-gamma expression localized to a variety of cell types in newly formed subcutaneous fat.
22455954 Down-regulation of PPARgamma expression by IL-1 requires de novo protein synthesis and is concomitant with induction of the transcription factor Egr-1.
22435140 Reversal of AGE on angiogenesis by treatment with PPAR gamma antagonists and up-regulation of PPAR gamma gene in HUVECs treated with AGE-BSA suggested involvement of PPAR gamma-dependent downstream pathway in mediating the angiogenic effect of AGE.
22426809 Evaluated clinical significance of PPAR-gamma in NSCLC. Positive PPAR-gamma expression was prominent in 45 % out of 67 NSCLC cases. PPAR-gamma positivity was more frequently observed in squamous cell lung carcinoma cases compared to lung adenocarcinoma ones.
22413765 we did not detect significant variations of weight gain among the different PPARG Pro12Ala genotypes.
22410809 The ProAla+AlaAla genotypes of peroxisome proliferator-activated receptor gamma (PPAR-gamma) Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association.
22378291 Interaction between PPARG Pro12Ala and PPARA Leu162Val genotypes may influence plasma LDL cholesterol concentration and the proportion as small dense LDL after a high monounsaturated fatty acids diet.
22377103 The CLZ-Pro/Ala genotype displayed higher glucose levels than the CL-Pro/Pro group. The total cholesterol, triglycerides and the triglyceride/HDL-c ratio were also numerically higher in CLZ-Pro/Ala carriers and opposite pattern was observed in controls
22366735 Monosodium urate crystals induced cells to increase VCAM1. Activation of the MAPK signal pathway and PPARG may contribute to this increase.
22363753 A small-angle X-ray scattering analysis of the oligomeric state of hPPARgamma alone and in the presence of retinoid X receptor (RXR), is reported.
22363123 Results evaluate simultaneous leptin and PPARgamma expression in colorectal adenomas in relation to BMI and characteristics of adenomas.
22349506 PPARalpha and PPARgamma activation modulate hENT1 expression.
22349439 PCOS rat models also showed alterations of PPARG1, NCOR1, and HDAC3 mRNA expression and methylation changes of PPARG1 and NCOR1, consistent with the results from humans.
22342541 005037.5a 005037.5a
22334075 PPARgamma contributes to PKM2 and HK2 expression in fatty liver
22321707 Rosiglitazone inhibited inflammation in COPD through upregulating the expression and activity of PPAR-gamma and inhibiting NF-kappaB and TNF-alpha.
22301832 Genetic variation in peroxisome proliferator-activated receptor gamma is associated with breast neoplasms.
22293175 PPARgamma agonists enhance the differentiation process initiated by ET-743
22286757 UHRF1 coordinates peroxisome proliferator activated receptor gamma epigenetic silencing and mediates colorectal cancer progression.
22282354 TGF-beta1 downregulates AT1 receptor expression via PKC-delta-mediated Sp1 dissociation from KLF4 and Smad-mediated PPAR-gamma association with KLF4.
22276212 AlaAla genotype may be a protective factor in the European Caucasian population against the development of Crohs disease in a recessive way.
22268120 data are consistent with the hypothesis PPARgamma stimulates MUC1/Muc1 expression, thereby blocking phorbol 12-myristate 13-acetate-induced TNF-alpha/IL-8 production by airway epithelial cells.
22248180 Cucurbitane-type triterpene glycosides from Momordica charantia inhibited NFKB activation and stimulated PPARg activation.
22240811 Loss of SERCA2 expression is observed in human diabetes and occurs within the context of PPAR-gamma phosphorylation and CDK5 activation.
22210720 Data show that RXRalpha was strongly and moderately expressed in 11 (14.10%) and 33 (42.31%) cases, respectively, and PPARgamma was strongly and moderately expressed in 33 (41.25%) and 25 (31.25%) cases, respectively.
22207732 Identify a positive cross-talk between PPARgamma and glucocorticoid receptor in human M2 macrophages via the induction of 11beta-HSD1 expression and activity.
22205725 PPAR/RXR pathway contribute to endometrial carcinogenesis.
22192353 Thiazolidinediones decrease the proinflammatory cytokines IL-6 and IL-8 in endometrial stromal cells via a PPAR-gamma-independent mechanism.
22179955 Ala12 allele at PPARG associated with short- and long-term weight loss (-0.63 and -0.93 kg/allele, P </= 0.005, respectively).
22174394 Specific transient increases in monocyte expression of PPARgamma-regulated genes were observed within 1.5-3 h of exercise.
22169113 PPAR-gamma agonists and statin therapies have complementary effects in improving lipoprotein subfractions associated with atherogenic dyslipidemia.
22168210 Carriers of PPARgamma2 Ala allele had higher BMI and fat-mass but not a worse metabolic profile, possibly because of a more favorable adipose tissue distribution. A gene interaction exists between Pro12Ala and ACE I/D on BMI and fat mass.
22160635 Genetic variation in PPARG is associated with NAFLD, and the GT haplotype is associated with inflammatory and fibrotic changes that denote histologically advanced NAFLD
22152242 The expression level of PPARg in acute-on-chronic liver failure patients were much higher than chronic liver failure patients, chronic hepatitis B patients and normal controls.
22129188 Increased body mass index but not common vitamin D receptor, peroxisome proliferator-activated receptor gamma, or cytokine polymorphisms confers predisposition to posttransplant diabetes.
22120719 ability of PPARgamma to promote or suppress tumor formation is linked to cell type-specific differences in regulation of NHE1 and other target genes.
22120652 PPARgamma suppression inhibits adipogenesis but is not the master factor regulating mesenchymal lineage determination in human bone marrow.
22108328 The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation, at least partly, via PPARgamma activation.
22103651 Tis meta-analysis suggests that the Pro12Ala polymorphism of the PPARG gene may be associated with diabetic nephropathy among Asians.
22102511 We found a gene-diet interaction between the PPARgamma Pro12Ala polymorphism and monounsaturated fatty acid intake for BMI and body fat.
22095559 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
22056426 The beta-catenin signal was activated by endogenous Wnt through interaction with chondroitin sulfate chains to suppress PPARG expression on the stem cell matrices and early stage matrices but not on late stage matrices
22040870 We investigated the effect of dietary fatty acid interaction with PPARG, PPARA and ADIPOQ gene variants on plasma lipid and adiponectin concentrations...
22025054 Studies indicate that the M1 macrophage phenotype is controlled by STAT1 and IRF5, whereas STAT6, IRF4 and PPARgamma regulate M2 macrophage polarization.
22021335 PPAR-gamma/delta signaling accounts in part for the vasodilating effect of prostacyclins in pulmonary arteries.
22020928 Ligands for peroxisome proliferator-activated receptor gamma (PPARgamma) such as pioglitazone (Pio) and rosiglitazone potentiated the cytotoxic action of Gem on human pancreatic cancer cells in a dosage-dependent manner.
22017455 Cardiovascular risk factors related to the PPARgamma Pro12Ala polymorphism in patients with type 2 diabetes are gender dependent.
22009745 Study describe a novel human liver-specific PGC-1alpha transcript that results from alternative promoter usage and is induced by FOXO1 as well as glucocorticoids and cAMP-response element-binding protein signaling but is not present in other mammals.
22001700 Levels of serum lipid/lipoprotein were not associated with the Pro12Ala polymorphism in PPAR-gamma2 among Chinese nonagenarians and centenarians, which was different from the general population
22001530 The TNIP1 distal promoter, approximately 4600 nucleotides upstream of a frequently utilized transcription start site region, contains PPAR gamma and NF-kappaB sites that bind the respective transcription factors in vivo.
21986923 Rosiglitazone, a PPAR-gamma agonist, inhibits VEGF secretion by peripheral blood mononuclear cells and ROS production by human leukocytes
21986665 we have provided convincing evidence that RU-486 regulates the transcriptional activity of PPARgamma by binding to its ligand binding domain.
21982524 Alveolar macrophage PPAR-gamma functional activity was decreased by 48% in obese with obstructive sleep apnea (OSA) and by 26% in obese without OSA.
21968139 an association between type 2 diabetes mellitus and Pro12Ala single-nucleotide polymorphism (SNP) in PPARgamma
21949049 the effect of interaction between genotype and the ratio of polyunsaturated:saturated (P:S) fatty acid intake on plasma lipids
21939732 Our results indicated that the peroxisome proliferator-activated receptor gamma rs1801282 C/C genotype and smoking were significant independent risk factors for non-alcoholic fatty liver disease
21911496 analysis of a novel anti-inflammatory mechanism of endothelial PPARgamma activation that involves targeting protein post-translational modification of adhesion molecules, specifically N-glycosylation
21896780 MKK4 deficiency increased peroxisomal proliferator-activated receptor gamma2 (PPARgamma2) expression through noncanonical MKK4 substrates, and PPARgamma2 enhanced tumor cell invasion.
21885829 Early atheroma-derived agonists of peroxisome proliferator-activated receptor-gamma trigger intramedial angiogenesis in a smooth muscle cell-dependent manner.
21861709 The A allele of RAGE -374T/A polymorphism in diabetic CAD patients and the-374T/Ala12 haplotype of RAGE -374T/A and PPAR-gamma Pro12 Ala polymorphisms in the patients group are the most important risk factors for CAD.
21853931 The frequency of the Pro12Ala polymorphism observed in the sample of women from the Lower Silesian population was significantly higher than in the majority of European populations.
21833536 Homozygote CC genotype of the PPARgamma C161T polymorphism might be associated with an increased coronary heart disease risk especially in patients with diabetes.
21833030 study investigated how the phosphorylation of serine 273 in PPARgamma shifts the protein population towards a malfunctioning state and consequently perturbs cellular molecular networks, eventually leading to the development of insulin resistance
21827375 In the polycystic ovary syndrome women, a single Ala allele may have a protective role as far as hyperleptinemia is concerned
21821917 Data describe a BMPR2-mediated transcriptional complex between PPARgamma and beta-catenin, and suggest that apelin could be effective in treating PAH by rescuing BMPR2 and PAEC dysfunction.
21820420 It was concluded that PPAR-gamma activation by L. barbarum extract is associated with its taurine content and may explain at least in part its use in diabetic retinopathy progression.
21795447 These results from a haplotype analysis, show for the first time that genetic variations in the PPARgamma gene could play a role in the susceptibility to develop gestational diabetes
21785974 The results indicated that nuclear receptors PPAR-gamma and PPAR-alpha are involved in the regulation of inflammatory mediator production.
21781307 Data suggest that PPARgamma promotes survival for some ovarian tumor cells.
21765467 PPARdelta and PPARgamma coordinately regulate cancer cell fate by controlling the balance between the cell death and survival
21764381 Two common gene polymorphisms of PPARgamma may improve fertilization in vitro and, thus possibly, female fertility.
21763631 have quantified the HMGA2 mRNA level, which was not elevated in the two adenomas with the PAX8- PPARG fusion, compared to histologically normal thyroid tissue
21756892 The rs12497191 genotype could contribute to the incidence of non-traumatic hip fractures in the elderly.
21734368 pretreatment with rosiglitazone could attenuate kidney inflammation through the activation of PPAR-gamma, suppression of MCP-1 overproduction and NF-kappaB activation
21726861 statins have a role in coronary artery disease and influence PPARgamma expression in coronary plaques and affect the inflammatory status of patients
21710534 We demonstrated a significant association between PPARgamma polymorphisms and the development of Crohn disease and ulcerative colitis at single loci level and also in haplotype combinations.
21709632 PPAR-gamma and RXR-alpha expression down-regulation in macrophages and smooth muscle cells was associated with a more pronounced disease progression in patients with advanced carotid atherosclerotic lesions.
21704384 these data underscore the role of PPAR-gamma in the control of human trophoblast differentiation and invasion, and suggest that overactivation could impair implantation and placentation and therefore embryonic development.
21704006 PPARgamma ligands counteract leptin stimulatory effects on breast cancer growth in either in vivo or in vitro models
21700710 Peroxisome proliferator-activated receptor gamma induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: potential role in atherosclerosis.
21690289 a novel mechanism of PPARgamma regulation by which Ras/MAPK inhibitors act as scaffold proteins that sequester and sensitize PPARgamma to ligands, limiting proliferation of gastric epithelial cells.
21674037 ox-PAPCs enhanced PPARgamma2 and adipogenic gene expression and reduced Runx2 and osteoblast differentiation marker gene expression in differentiating mesenchymal stem cells
21669017 Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma was not associated with obstructive sleep apnoea hypopnoea syndrome, but was associated with increased hyperlipidaemia risk.
21664967 Blockade of PPARgamma can restore transforming growth factor beta-caused growth inhibition of cells.
21664456 activation through Nox2-derived ROS promotes cell-cycle progression in normal mouse lungs and in cultured normal alveolar epithelial cells
21646797 PPARgamma is involved in nasal polyposis pathogenesis, acting on eosinophils and T cells.
21643757 The PPARgamma C1431T polymorphism is associated with decreased risk of CAD in Chinese Han population.
21632707 A novel pathway is required that involves PPARgamma as a transcriptional regulator linking lipid metabolism and processing of lipid antigens, in complex with CD1d molecules, to invariant natural killer (NK)T cells.
21619898 Efavirenz caused a dose-dependent repression of adipocyte differentiation that was associated with down-regulation of the master adipogenesis regulator genes SREBP-1, PPARgamma, and C/EBPalpha.
21613824 Data show that troglitazone induced the expression of PPARgamma in the nuclear of PC-3 cells, but not in LNCaP cells.
21612582 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
21570865 Data show that PEDF inhibits the production of IL8 in human hormone-refractory prostate cancer cells, through PEDF receptor/phospholipase A2 regulation of NFkappaB and PPARgamma, and delays the growth of these cells in vitro.
21548985 Polymorphisms in APOA5 (-1131T > C, S19W), PPARgamma (Pro12Ala) and hepatic lipase (-514C > T) were studied in 1492 subjects from the
21544861 15-lipoxygenase-1 exerts its tumor suppressive role by inhibiting nuclear factor-kappa B via activation of PPAR gamma
21540831 Interaction effect between PPARgamma gene (PPARG) polymorphisms Pro12Ala and 1431C>T and fat intake on incident T2D and BMI in a 9-year prospective cohort drawn from the French general population
21528816 The association between PPAR-gamma2 Prol2Ala polymorphism and glucose metabolism is already present in children and adolescents with obesity who might be at the very beginning of the natural course of type 2 diabetes.
21508507 there is a significantly higher frequency of peroxisome proliferator-activated receptor gamma 2 (Ala12) allele in obese Asian Indians with obstructive sleep apnea (OSA) when compared to obese Asian Indians without OSA
21501146 The role of PPAR gamma in the development of diabetic retinopathy and potential therapies are briefly discussed.
21493814 PPARgamma2 Ala12 variant is significantly associated with a reduced risk of albuminuria among patients with type 2 diabetes.
21489836 The combination of the expression of the genes for PPARgamma, STMN1 and CAV2 was significantly predictive for early recurrence of non-muscle-invasive bladder cancer
21487230 Gene-diet interactions were also found for PPARgamma P12A polymorphism with saturated fat intake.
21479595 The Y151C mutant in familial partial lipodystrophy displayed impaired DNA-binding capacity and hence reduced transcriptional activity compared with wild-type PPARgamma.
21478865 The solution structure of PPARgamma2 was determined using small-angle-scattering and FRET.
21473290 Enhanced PPAR-gamma expression may correlate with the development of Barrett's esophagus and esophageal adenocarcinoma.
21467033 Synergistic interactions between heregulin and peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist in breast cancer cells.
21457357 PPAR and LXR activators stimulate AQP3 expression, providing an additional mechanism by which PPAR and LXR activators regulate epidermal function.
21451128 PPARgamma activation can be regulated by dietary factors such as probiotic oligosaccharides; PPARgamma is involved in regulation of expression of peptidoglycan recognition protein 3 in intestinal mucosa by dietary components
21426847 The expression of PPARgamma is enhanced significantly while the expression of COX2 and PGE(2) are attenuated markedly when the orbital pre-adipocytes differentiated into adipocytes in thyroid-associated ophthalmopathy.
21415255 PPARgamma expression is increased in systemic lupus erythematosus patients and represses CD40/CD40L signaling pathway
21410980 PPARgamma binding site retention is increased by the presence of a C/EBPalpha consensus site, suggesting that C/EBPalpha may facilitate PPARgamma binding to DNA.
21358044 Down-regulation of PPARgamma co-activator-1alpha (PGC-1alpha) appears to be dependent on PPARgamma.
21350215 In M2 macrophage subpopulations PPARgamma activation enhances the phagocytic but not the cholesterol trafficking pathways.
21325464 PPAR-gamma is up-regulated in the liver of obese patients with nonalcoholic fatty liver disease
21317313 PPAR is a nuclear hormone receptor and transcription factor that is essential for normal adipogenesis and glucose homeostasis.
21301856 The relations of erythrocyte PUFA to CRP or adiponectin mostly did neither strongly nor significantly vary by PPARG2 genotype.
21296999 Regulation of dectin-1-mediated dendritic cell activation by peroxisome proliferator-activated receptor-gamma ligand troglitazone.
21292830 despite the conservation of the canonical binding motif, the great majority of binding regions for FOXA2 in human liver and for PPARgamma in human adipocytes are not in the orthologous locations corresponding to the mouse genome, and vice versa
21291392 Ligand chirality plays the crucial role in the activation of PPARgamma. (Review)
21288452 High-dose daidzein mainly acts on PPARgamma to inhibit proliferation of osteoblasts.
21284483 genetic association studies: investigation of 3 SNP in PPARg (and 4 SNP in RXRa) in association with type 2 diabetes in a Chinese Han population; linkage disequilibrium; multifactor dimensionality reduction; association with plasma adiponectin
21266034 COX-2 might mediate tumor angiogenesis and growth, and could be considered as a target for gastric cancer therapy.
21265110 Pro12Ala polymorphism in PPARgamma2 of patients with primary hypertension may not associate with cognitive impairment.
21263402 PPARG and LPIN1 gene polymorphisms role of these genes in lipid metabolism and pathogenesis of type 2 diabetes and metabolic syndrome
21253589 PPAR-gamma ligands inhibit human myofibroblast differentiation of normal and idiopathic pulmonary fibrotic (IPF) fibroblasts, by blocking Akt phosphorylation at Ser473 by a PPAR-gamma-independent mechanism.
21252350 This study could not show a significant association between PPARG gene variants and chronic periodontitis.
21251908 through modulation of PPARgamma or ALDH3A1, it may be possible to reduce cell proliferation in tumor cells or stimulate cell proliferation in normal cells during tissue regeneration.
21247904 MITR plays a master switch role to balance osteogenic and adipogenic differentiation of MSCs through regulation of PPARgamma-2 transcriptional activity.
21245992 PXR and LXR polymorphisms, but not NF-kB or PPARgamma, may contribute to risk of IBD, especially among never smokers
21245597 These data indicate that PPARG2 gene has a protective effect against the onset of osteoarthritis.
21233811 genetic association studies: A single nucleotide polymorphism in PPARG is linked to waist-to-hip ratio in the quilombos of Brazil, but is not directly linked to obesity/overweight.
21229639 Low peroxisome proliferator-activated receptor gamma is associated with bladder urothelial carcinomas.
21207518 This gene is one of the most studied as potentially linked to the development of obesity, and especially related to the interactions with lifestyle factors.
21206970 PPARgamma is expressed and functional in clear cell renal cell carcinoma (CCRCC), prerequisites for being a potential target for CCRCC treatment.
21206011 Homozygosity for the Ala allele at codon 12 of the PPARgamma2 gene resulted in reduced risk of CAD.
21185561 meta-analysis suggests that, compared with non-carriers, carriers of Ala allele have significant increased blood total cholesterol in male subjects, and marginally significant increased blood HDL-C in healthy subjects.
21176858 PPARgamma mediates a modulation of PGlyRP3 gene expression, which is involved in inhibiting inflammation through negative regulation of NF-kappaB pathway.
21159608 Activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) inhibits transforming growth factor beta (TGF-beta)-induced epithelial-mesenchymal transition in lung cancer cells and prevents metastasis by antagonizing Smad3 function.
21156835 The CC genotype of C1431T in the PPARgamma2 gene together with low cardiorespiratory fitness may increase the risk of metabolic syndrome in younger men.
21156825 Telmisartan-induced inhibition of vasoconstriction in resistance arteries is mediated through a PPARgamma-dependent increase in eNOS expression and activity that is unrelated to ATR blockade.
21155004 linkage of malfunctioning Ala12-positive PPARgamma2 isoform to increased risk of alcoholic fatty liver disease patients to develop severe steatohepatitis and fibrosis indicates more prominent antiinflammatory impact of PPARgamma2 in progression of AFLD than NAFLD
21151932 peroxisome proliferator-activated receptor gamma may have a role in colorectal cancer progression and adverse outcome
21150196 results suggest fat oxidation and energy expenditure may be lower in Pro12Pro carriers compared to Pro12Ala/Ala12Ala genotypes, while in obese women with Pro12Ala/Ala12Ala polymorphisms, fat oxidation was negatively correlated with MUFA and PUFA intake
21148223 Upregulation of the synthesis of proinflammatory mediators by human lung epithelial cells induced by monocyte/macrophage-derived microparticles is mediated by NF-kB activation through a PPAR-gamma dependent pathway.
21146687 conclusion, treatment with telmisartan results in an increase of PPAR-gamma gene expression in peripheral monocytes in patients with essential hypertension
21140205 there was no evidence of a significant impact of individual polymorphisms of PPARgamma on breast cancer risk
21135166 Activation of PPARgamma and retinoid X receptor alpha in floxed mice with lupus nephritis in the context of autoimmunity against dying cells has distinct effects on phagocytosis and the preservation of self-tolerance.
21135128 miR-130 reduces adipogenesis by repressing PPARgamma biosynthesis
21109018 The role of KLF6 and PPAR-gamma in MIP-3alpha transcriptional regulation, was determined.
21106862 PPAR-gamma suppresses CYP11B2 expression/aldosterone secretion through calcium/calmodulin-dependent kinase I, which may account for the suppressive effects of PPAR-gamma on vascular events associated with atherosclerosis and hypertension.
21105983 Results indicate that Neisseria lactamica plays an important role in suppressing pathogen-induced inflammation in the nasopharyngeal mucosa, mediated through TLR-1/2 stimulation, by activating PPAR-gamma and inhibiting NF-kappabeta activity.
21104228 This study suggests an association between SNP's in PPARG and haplotypes thereof and bone mineral density and fracture risk.
21095215 This study found no an association of PPARgamma2 gene polymorphisms with MS or obesity in our schizophrenia sample.
21093321 STAT6 acts as a facilitating factor for PPARgamma by promoting DNA binding and consequently increasing the number of regulated genes and the magnitude of responses.
21072170 Results show that a marked attenuation of PPAR-gamma levels and transcriptional activity in a subset of patients with diffuse cutaneous SSc.
21061265 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
21059659 XOR promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, PPARgamma SUMOylation, and HIF-1alpha
21059469 Hepatitis B virus replication was upregulated by adiponectin and PPARgamma agonist rosiglitazone treatments and was downregulated by adiponectin siRNAs.
21057731 Studies indicate that PPARgamma as a possible therapeutic target approaching major, severe diseases, such as sepsis, cancer, and atherosclerosis.
21054877 Observational study of gene-disease association. (HuGE Navigator)
21044285 The rare allele of His447His of PPARG showed significant association with chronic obstructive pulmonary disease outcome. In haplotype analysis the GC haplotype of PPARG conferred reduced risk for chronic obstructive pulmonary disease.
21044285 Observational study of gene-disease association. (HuGE Navigator)
21040163 PPAR-gamma expression increases with loss of renal function and may be an important factor in maintaining normal renal function serving as a key protective mechanism to renal injury.
21029675 Ciglitazone inhibits cell growth by induction of cell apoptosis in HL-60 cells via PPARgamma dependent and independent signaling pathways.
20970965 PPARgamma regulates the 1,25D-induced hBD-3 and cathelicidin expression in keratinocytes through the regulation of AP-1 and p38 activity.
20951680 These data suggest that PPARgamma may be important for regulation of the level of hepatic ABCA1 protein and indicate the new interplays between PPARgamma, LXRbeta and MEK1/2 in regulation of ABCA1 mRNA and protein expression.
20945045 Visfatin may down-regulate the ABCA1 expression and up-regulate the ACAT1 expression via PPARgamma signal transduction pathway, which decreases the outflow of free cholesterol, increases the content of cholesterol esters, and then induces foam cell formation.
20930717 diabetes mellitus patients harboring both D2 Ala/Ala genotype and PPARgamma2 Ala12 allele seem to present more severe IR than those with other D2/PPARgamma2 genotype combinations.
20930717 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20929593 Observational study of gene-disease association. (HuGE Navigator)
20929345 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
20923526 Meta-analysis and uncategorized study of gene-disease association. (HuGE Navigator)
20889853 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
20889551 CHOP and PPARgamma may represent critical mechanistic links between ribotoxic stress and proinflammatory cytokine production
20885348 Observational study of genotype prevalence. (HuGE Navigator)
20879858 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20870032 Chlamydia pneumoniae infections disturb cholesterol homeostasis in human THP-1 macrophages and Chlamydia pneumoniae infection disturbs cholesterol homeostasis via JNK-PPARgamma dependent signal transduction pathways.
20862655 In HepG2 cells, activation of PPARg preferentially results in a reduction of cell proliferation without inducing cell death.
20861226 In addition to its direct effect on renin gene transcription, PPARgamma "sensitizes" renin gene to cAMP via trans-activation of AC6 gene.
20857895 Observational study of gene-disease association. (HuGE Navigator)
20855565 Observational study of gene-disease association. (HuGE Navigator)
20853849 This study data suggested that SAA activated PPARgamma through extracellular signal-regulated kinase 1/2 (ERK1/2)-dependent COX-2 expression.
20848495 decreased gene expression of PPARgamma is associated with active ulcerative colitis.
20840271 The PPAR-gamma gene polymorphisms do not appear to affect the risk for PCOS, except for the reduced testosterone levels.
20840271 Observational study of gene-disease association. (HuGE Navigator)
20829347 Data show that ER stress can enhance proinflammatory NF-kappaB activation due to the CHOP-mediated regulation of PPARgamma action.
20825652 PPARgamma2 12Ala alleles were not associated with the severity of steatosis, necroinflammation, or fibrosis.
20825652 Observational study of gene-disease association. (HuGE Navigator)
20816152 Observational study of gene-disease association. (HuGE Navigator)
20811626 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20800603 Observational study of gene-disease association. (HuGE Navigator)
20738756 RT-PCR demonstrated that melatonin significantly suppressed PPARgamma expression but promoted Runx2 expression in the early stages of adipogenesis and osteogenesis of hMSCs.
20734220 PPARgamma's pro-apoptotic and anti-proliferative abilities appear to be triggered at least in part by the modulation of Skp2
20734064 Observational study of gene-disease association. (HuGE Navigator)
20733583 Observational study of gene-disease association. (HuGE Navigator)
20732852 Data show that activation of the PPARgamma/PGC-1alpha pathway may protect against COPD progression by upregulating gamma-GCS and relieving oxidative stress.
20723894 PPARgamma and Th2 cytokines (IL4, IL10) have roles in low-intensity exercise enhancement of expression of markers of alternative activation in circulating leukocytes
20722066 PPARgamma polymorphisms are not associated with inflammatory bowel diseases.
20722066 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20717101 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites.
20715992 Upregulation of PPARgamma is associated with gastric carcinoma.
20712903 Observational study of gene-disease association. (HuGE Navigator)
20694299 We evaluated the influence of dietary fat in glicidic metabolism in morbidly obese women with Pro12Pro genotype in the gene PPARgamma2
20694299 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20693905 (Review) PPARgamma has potent effects on inflammation, fibrogenesis and vascular remodeling and is important in the pathogenesis of fibrosis and pulmonary arterial hypertension, and as a potential therapeutic target in systemic sclerosis.
20682687 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20679960 Observational study of gene-disease association. (HuGE Navigator)
20673868 Observational study of gene-disease association. (HuGE Navigator)
20672248 PPARgamma plays a key role in age-related inflammation.
20668149 Observational study of gene-disease association. (HuGE Navigator)
20668019 White tea extract induces apoptosis via PPAR gamma and 15-lipoxygenases.
20656057 PPARalpha and gamma are activated, and COX-2 is suppressed by citral, a component of lemongrass oil
20653996 Study did not reveal any significant effect of the PPARalpha and PPARgamma2 polymorphisms on anthropometric, biochemical, hormonal and psycho-behavioural characteristics in obese women.
20653996 Observational study of gene-disease association. (HuGE Navigator)
20651683 findings strongly suggest that Cdk5-mediated phosphorylation of PPARgamma may be involved in the pathogenesis of insulin-resistance, and present an opportunity for development of an improved generation of anti-diabetic drugs through PPARgamma
20650551 None of the polymorphisms analyzed influenced disease susceptibility and/or activity, but a high intake of total, saturated and monounsaturated fats and a higher ratio of n-6/n-3 polyunsaturated fatty acids, was associated with a more active phenotype.
20650551 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20649594 Induction of 15-LOX-1-mediated down-regulation of a PPAR-gamma and COX-2 pathway by honokiol may be a promising therapeutic strategy for gastric cancer.
20645257 The +294T/C polymorphism in the PPAR-delta gene is associated with risk of coronary artery disease (CAD) in dyslipidemic women and hypercholesterolemic men.
20644561 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20640553 We found that Pro12Ala polymorphism in PPAR-gamma2 was not directly correlated with dementia among Chinese nonagenarians and centenarians
20640553 Observational study of gene-disease association. (HuGE Navigator)
20631015 Link between PPARgamma and renin raises the possibility of a genetically based mechanism for the increased volume retention and edema in some users of PPARgamma agonists.
20631015 Observational study of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20623456 The Ala allele is involved in genetic susceptibility to hypertension and metabolic lipid disorders in the Han population of Inner Mongolia.
20623456 Observational study of gene-disease association. (HuGE Navigator)
20621019 SNP and haplotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in traditional Chinese medicine.
20621019 Observational study of gene-disease association. (HuGE Navigator)
20616309 Observational study of gene-disease association. (HuGE Navigator)
20608974 PPARgamma ligands increase visfatin gene expression in a PPARgamma-dependent manner in primary human resting macrophages and in adipose tissue macrophages, but not in adipocytes
20606394 The minor Ala12 variant pf PPARG was associated with lower height in healthy prepubertal children indicating its possible effects on growth
20606394 Observational study of gene-disease association. (HuGE Navigator)
20602615 Observational study of gene-disease association. (HuGE Navigator)
20600006 The role of PPARgamma coregulators in adipogenesis and especially on the role of PPARgamma coregulators in white and brown adipose tissue, is discussed.
20596649 The PPARgamma C161T is marginally associated with cancer susceptibility.
20596649 Meta-analysis of gene-disease association. (HuGE Navigator)
20591056 PPAR gamma genetic mutation probably cause a subset of ulcerative colitis.
20591056 Observational study of gene-disease association. (HuGE Navigator)
20580778 adiposity in children is influenced by the PPARG Pro12Ala polymorphism in a sex-specific and age-dependent
20580778 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20580033 Observational study of gene-disease association. (HuGE Navigator)
20573495 Highest levels of PPARgamma were observed following treatment with a combination of oxysterols and lycopene, suggesting that NF-kappaB induced by oxysterols is associated with PPARgamma.
20571754 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20568969 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20560917 Results suggest that the PPAR-gamma Pro12Ala polymorphism is associated with advanced-stage endometriosis in the Korean population.
20560917 Observational study of gene-disease association. (HuGE Navigator)
20558736 Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis.
20556576 Troglitazone elevated PPARgamma activity and decreased P-gp expression in SGC7901/VCR cells, reversing the P-gp-mediated drug resistance.
20554962 Data identify a new molecular pathway that links engagement of the mannose receptor, an important pattern recognition receptor for M. tuberculosis, with PPARgamma activation, which regulates the macrophage inflammatory response.
20550665 Observational study of gene-disease association. (HuGE Navigator)
20543477 Mevastatin inhibits the differentiation of TAO derived orbital preadipocytes by blocking PPAR-gamma mRNA expression.
20542036 The roles of PPARgamma and C/EBPs in adipocyte differentiation with emphasis on the recently published genome-wide binding profiles for PPARgamma and C/EBPalpha, are reviewed.
20540670 Observational study of gene-disease association. (HuGE Navigator)
20536507 Observational study of gene-disease association. (HuGE Navigator)
20512989 acts as a tumor-suppressor gene in the liver
20512451 PPARG3 gene variants were not associated with coronary artery disease and metabolic risk factors of coronary atherosclerosis in a Russian population.
20512451 Observational study of gene-disease association. (HuGE Navigator)
20510503 RXRgamma and PPARgamma ligands acted synergistically to inhibit proliferation and invasiveness in colon cancer cells.
20503258 Observational study of gene-disease association. (HuGE Navigator)
20501643 The activity of the Sprouty4 promoter is increased by Wnt7A/Frizzled 9 homolog (Fzd9) signaling through peroxisome proliferator-activated receptor gamma in lung cancer cells.
20492333 Observational study of gene-disease association. (HuGE Navigator)
20490451 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20485444 Observational study of gene-disease association. (HuGE Navigator)
20484415 Studies indicate that PPARgamma activation inhibits PRB activity through both acute (phosphorylation) and long-term (PRB degradation) pathways.
20468064 Observational study of gene-disease association. (HuGE Navigator)
20453000 Observational study of gene-disease association. (HuGE Navigator)
20452482 Observational study of gene-disease association. (HuGE Navigator)
20450751 Neither the maternal nor the offspring's Pro/Ala PARG2 genotype is associated with the genesis of gestational diabetes mellitus.
20450751 Observational study of gene-disease association. (HuGE Navigator)
20450366 Pro12Ala polymorphism may represent a genetic susceptibility factor for the clinical measurements of periodontitis in a limited number of pregnant Japanese women, but it probably cannot influence the relationship between periodontitis and preterm birth
20450366 Observational study of gene-disease association. (HuGE Navigator)
20440859 PPAR-gamma 34 C>G is associated with colon cancer risk, but not associated with colorectal and rectal cancer risk.
20440859 Meta-analysis of gene-disease association. (HuGE Navigator)
20437825 Observational study of gene-disease association. (HuGE Navigator)
20437058 Observational study of genetic testing. (HuGE Navigator)
20430250 results imply a significant correlation of Ser447X polymorphism and its protective effect on Indians against severity of CAD modified by the risk of diabetes, than LPL HindIII and PPARgamma Pro12Ala
20430250 Observational study of gene-disease association. (HuGE Navigator)
20426853 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20424228 Observational study of gene-disease association. (HuGE Navigator)
20421464 PPARgamma functions as an antimicrobial factor by maintaining constitutive epithelial expression of a subset of beta-defensin in the colon
20420754 We found a significant association of the [Pro12]Ala allele with the lowest risk of type 2 diabetes mellitus in Caucasians...lower serum insulin...and greater sensitivity to insulin in overweight individuals...
20420754 Observational study of gene-disease association. (HuGE Navigator)
20413122 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20406953 derepression of peroxisome proliferator-activated receptor-gamma transcription by the high levels of forkhead box O1 could partially account for the lower levels of SLC2A4 found in polycystic ovary syndrome
20403997 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20399568 The mRNA levels of PPAR-alpha and PPAR-gamma increased significantly in atherosclerosis
20392673 Observational study of gene-disease association. (HuGE Navigator)
20388362 Several indices of individuals with PPARgamma2 Pro/Pro polymorphism improved obviously after nutrition intervention.
20388362 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20384434 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20372816 Results indicate that resveratrol prevents the impairment of advanced glycosylation end products on macrophage lipid homeostasis partially by suppressing RAGE via PPARgamma activation.
20372080 Knockdown of PPARgamma did not impair thiazolidinedione mediated downregulation of FoxM1 mRNA expression, providing further evidence that thiazolidinedione mediated downregulation of FoxM1 gene expression occurs in a PPARgamma-independent manner.
20368233 observation strongly supports the implication of the PPARG Pro12Ala in insulin resistance and type 2 diabetes in a Russian population
20368233 Observational study of gene-disease association. (HuGE Navigator)
20364085 Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans
20361309 Results suggest that the PPARgamma agonist KR62776 may have potential in the chemoprevention of liver fibrosis/cirrhosis.
20360975 a complex interplay of Sp1 and PPARgamma along with other transcription factors drives the expression of resistin in human monocytic U937 cells
20357037 findings show that PPAR-gamma is involved in the regulation of SOCS-7 expression by hepatitis C virus core protein genotype 3a
20346360 Observational study of gene-disease association. (HuGE Navigator)
20334678 results indicate that the peroxisome proliferator-activated receptor gamma (PPARgamma) C161-->T polymorphism may reduce the risk of severe atherogenesis by modulation of adipose metabolism
20334678 Observational study of gene-disease association. (HuGE Navigator)
20302927 oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells
20299237 The effect of IFNalpha, IFNbeta and IFNgamma on the secretion of the Th1 chemokines CXCL9 and CXCL10, in primary cultures of human thyroid follicular cells and to assess the effect of PPARgamma activation on CXCL9 and CXCL10 secretion, were tested.
20238044 The expression of genes involved in lipid metabolism and expression of the three isoforms of PPARs in an immortalized cell line of human retinal pigment epithelial cells, were investigated.
20224667 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20221637 PPARgamma as an alternative COX-independent mechanism of VEGF induction in colorectal tumor cells.
20203524 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20198337 PTEN and PPARgamma are up-regulated in leiomyoma tissues. Estradiol stimulates expression of PTEN and PPARgamma in leiomyoma cells, but not in normal cells.
20186155 Observational study of gene-disease association. (HuGE Navigator)
20179158 Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator)
20178607 RGZ and CGZ inhibited profibrotic changes in TGF-beta1-stimulated A549 cells independently of inhibition of Smad phosphorylation.
20174813 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20164187 inhibition of miR-27b, which was induced upon LPS exposure, partially reversed PPARgamma1 mRNA decay, whereas miR-27b overexpression decreased PPARgamma1 mRNA content
20161779 Observational study of gene-disease association. (HuGE Navigator)
20158084 The polymorphism in human PPARG gene resulting in the substitution of Pro12 to Ala in the PPARgamma2 isoform has been established as conferring anti-diabetic and anti-obesity effects, especially in the conditions.
20145925 Observational study of gene-disease association. (HuGE Navigator)
20130411 in polycystic ovary patients, the PPAR-gammaPro12Ala and the PGC-1alpha Gly482Ser polymorphism may modulate the concentrations of serum HDL levels and postprandial 2-hour insulin level, respectively
20123124 first PPARG germline mutation associated with dyslipidemia and colonic polyp formation that can progress to full-blown adenocarcinoma
20112822 Primary pioglitazone failure in Asian Indian type 2 diabetics cannot be explained on the basis of Pro12Ala polymorph of PPAR-gamma gene.
20112822 Observational study of gene-disease association. (HuGE Navigator)
20102333 the human AACS promoter is a PPARgamma target gene and this nuclear receptor is recruited to the AACS promoter by direct interaction with Sp1
20093779 the PAR-bZIP (bZIP, basic leucine zipper) family and E4BP4 are the main regulatory factors involved in oscillation of novel PPARgamma expression
20079163 Data observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion.
20079163 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20078877 Observational study of gene-disease association. (HuGE Navigator)
20075150 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
20070288 Hypertensive disorders in pregnancy were not associated with the leptin, leptin receptor, and PPARgamma2 polymorphisms studied.
20070288 Observational study of gene-disease association. (HuGE Navigator)
20070029 could not find an association of L162V PPAR-alpha, C161T PPAR-gamma and A(39526)AA RXR-alpha gene polymorphisms with angiographic in-stent restenosis or major cardiac events.
20070029 Observational study of gene-disease association. (HuGE Navigator)
20062524 the modulation of Dectin-1 expression by IL-13 involves the PPARgamma signaling pathway
20059631 Observational study of gene-disease association. (HuGE Navigator)
20054646 New troglitazone derivatives devoid of PPARgamma agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines.
20045799 The Pro12Ala polymorphism of the PPAR-gamma gene is not involved in the pathogenesis or the phenotypic expression of PCOS.
20045185 PPARgamma may be involved in the pathophysiology of gestational diabetes, preeclampsia, and IUGR.
20045142 The PPAR-gamma Pro12Ala gene polymorphism is associated with the response to pioglitazone in Chinese patients with type 2 diabetes mellitus.
20045142 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20043145 No evidence of association between type 2 diabetes susceptibility in patienets with the PPARG Pro12Ala variant.
20043145 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20042507 Data show that human cytomegalovirus infection induces peroxisome proliferator-activated receptor gamma transcriptional activity in infected cells.
20033348 results provide a possible proof of SIRT1 protective potential in visceral adipose tissue against nonalcoholic fatty liver disease in humans.
20032817 Fetal sex/sex chromosomes may substantially affect maternal glycemic control in mothers who are carriers of the GG alleles of the PPARgamma2 Pro12Ala polymorphism.
20032817 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20032081 The anti-angiogenic effect of PPARgamma agonists is due, at least in part, to an interference with the VEGF-stimulated PKCalpha-mediated activation of CREB and the related expression of COX-2.
20026644 CK-II-dependent PPARgamma phosphorylation at Ser16 and Ser21 is necessary for CRM1/Ran/RanBP3-mediated nucleocytoplasmic translocation of PPARgamma.
20021931 In rosiglitazone-treated macrophages, PPAR-gamma mRNA expression was significantly lower while NF-kappaB P65, TIMP-1 and MMP-9 expression were significantly higher in acute coronary syndrome group than in controls.
20021832 The expressions of PPARgamma and VEGF-C are significantly correlated with the clinicopathological characteristics and biological behavior of extrahepatic cholangioadenocarcinoma.
20016803 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19996102 Pin1 regulates macrophage function through the direct binding to the phosphorylated AF-1 domain of PPARgamma
19963130 It is hereby concluded that 3p25 aneusomy or PAX8-PPARG translocation may play an important role in the molecular pathogenesis of follicular thyroid tumors
19958503 results suggest that both NHE1 and MnSOD have peroxisome proliferator response elements binding motif in their upstream/promoter region and hence are regulated by PPAR upon ligand binding.
19956635 Uncategorized study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19948975 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator)
19948841 PLA2-modified LDL transactivates macrophage PPARalpha and PPARdelta, but not PPARgamma.
19923924 Autophagy promoted via troglitazone is correlated with AMPKalpha activation and independent of PPARgamma activation and EGFR transactivation.
19915048 low doses of PPARgamma/RXRalpha ligands could be used as a new type of adjuvant to stimulate Ab production.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19900151 The +A2962G of PPARGC1A and the 3 polymorphisms of PPARG were not associated with diabetic nephropathy.
19900151 Observational study of gene-disease association. (HuGE Navigator)
19898482 Observational study of gene-disease association. (HuGE Navigator)
19890028 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19888469 PPARgamma is a molecular target of ghrelin signaling in macrophages
19887620 data provide evidence for tumor-selective downregulation of NHE1 by activated PPARgamma
19884280 In human liver, PPARgamma mediates the induction of CYP26B1.
19878569 Observational study of gene-disease association. (HuGE Navigator)
19876004 Observational study of gene-disease association. (HuGE Navigator)
19862325 there is an association between PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 and type 2 diabetes in the Chinese population
19862325 Observational study of gene-disease association. (HuGE Navigator)
19859551 Observational study of gene-disease association. (HuGE Navigator)
19850645 These data suggest that PPARgamma activation represses FKN signaling.
19846795 Breast-feeding appears to counter the deleterious effect of the PPARG2 Pro12Ala polymorphism on anthropometric parameters in adolescents.
19846795 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19846218 hCG gene expression is differentially regulated in villous and invasive extravillous trophoblasts during their in vitro differentiation and modulated in an opposite way by PPARgamma.
19846176 the genetic variation in PPARG and ADIPOQ loci could contribute to the risk for the development of T2D in Indian Sikhs.
19846176 Observational study of gene-disease association. (HuGE Navigator)
19846173 the A-Ala-T haplotype at the PPARG2 locus is associated with the reduced risk of type 2 diabetes mellitus.
19846173 Observational study of gene-disease association. (HuGE Navigator)
19837787 Results indicated that the Pro/Pro genotype of PPARG and smoking were significant independent risk factors for diabetic nephropathy.
19837787 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19829671 The decreased expression of PPARgamma and enhanced expression of NF-kappaB play a role in the pathogenesis of pulmonary fibrosis.
19818126 Observational study of gene-disease association. (HuGE Navigator)
19808901 The alanine-12 variant of the PPARgamma gene is associated with higher weight gain during growth hormone treatment in subjects born small for gestational age.
19808901 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19808645 Data suggest that Txnip expression and promoter activity are mediated via divergent effects of KLF6 and PPAR-gamma transcriptional regulation.
19805902 Single-nucleotide polymorphisms in PPARG and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population are reported.
19800867 these results suggest that the anti-adipogenic effect of miR-27b in hMADS cells is due, at least in part, to suppression of PPARgamma.
19797172 mTOR/Akt2 is required for optimal PPARgamma activation. Patients who receive SESs during concomitant RSG treatment may be at risk for delayed stent healing.
19797117 Pax8-PPARG fusion protein and Pten synergistically cause thyroid hyperplasia in transgenic mice.
19796634 High glucose enhanced Ang-II-mediated peroxisome proliferation-activated receptor-gamma inactivation and expression of proinflammatory adhesion molecules in human coronary artery endothelial cells.
19794065 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19789190 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19787196 Downregulation of XIAP and activation of capase-3 play an important role in mediating the PPAR-gamma-dependent cell death.
19772889 Data show that GATA-2 expression by MSCs from AA patients was significantly lower than in normal subjects, and conversely, expression of PPARgamma was significantly higher in AA patients.
19766907 among Chinese nonagenarians and centenarians, the Pro12Ala polymorphism in PPARgamma2 was associated with depression and that the 12Ala gene may be a factor for decreased depression.
19766907 Observational study of gene-disease association. (HuGE Navigator)
19760975 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19760027 Observational study of gene-disease association. (HuGE Navigator)
19756148 analysis of PPARgamma ligand modulated antagonism by genomic and non-genomic actions of PPARdelta
19745552 Healthy men, in particular nonsmokers, carrying the Ala12 allele of PPARG rs1801282 polymorphism, have a high risk for metabolic syndrome and insulin resistance.
19745552 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19737866 identify the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) as a key negative regulator of human and mouse Th17 differentiation.
19733160 present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin
19733160 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19730683 Observational study of gene-disease association. (HuGE Navigator)
19729601 Observational study of gene-disease association. (HuGE Navigator)
19727905 Observational study of gene-disease association. (HuGE Navigator)
19724872 underexpression of PPARgamma is associated with poor tumour differentiation, aneuploidy and higher cell proliferative activity in thyroid follicular carcinoma
19720844 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19720797 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19714744 SNP C161T associated with ulcerative colitis in Chinese but not Dutch patients
19712722 These results suggest that relaxin activates PPARgamma activity and increases the overall response in the presence of PPARgamma agonists, and that this activation is dependent on the presence of RXFP1.
19701967 study suggests that PPAR-gamma may be involved in gastric carcinogenesis
19692168 Observational study of gene-disease association. (HuGE Navigator)
19683227 In peritoneal endometriotic lesions, the expression of peroxisome proliferation-activated receptor gamma is positively correlated with the pain reported by patients.
19681917 Meta-analysis of gene-disease association and gene-gene interaction. (HuGE Navigator)
19680556 Observational study of gene-disease association. (HuGE Navigator)
19673747 Observational study of gene-disease association. (HuGE Navigator)
19660836 The results of this study suggested that PPAR-gamma genetic variants may modify the risk of alzheimer disease in an APOE epsilon4 allele-dependent fashion.
19651920 Single nucleotide polymorphisms of PPARG is a strong predictor of ischemic stroke in diabetic patients.
19651920 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19644638 results suggest, for the first time, that the genetic polymorphism in PPARG is not a major contributor to the observed variability in peak bone mineral density at the lumbar spine and femoral neck in Chinese women.
19644638 Observational study of gene-disease association. (HuGE Navigator)
19644041 the expression of PPAR-gamma is significantly higher in coronary artery disease patients than in healthy donors and that, together with cytokine release, it seems to be gender-related
19634985 results suggest that adiposity in children is influenced by the Pro12Ala polymorphism in a gender specific manner.
19634985 Observational study of gene-disease association. (HuGE Navigator)
19633298 Data show that the coordinated PPARgamma-mediated regulation of the GPR81, GPR109A and GPR109B presents a novel mechanism by which TZDs may reduce circulating free fatty acid levels and perhaps ameliorate insulin resistance in obese patients.
19631630 PPAR-gamma Pro12Ala polymorphism was not associated with an increased risk of Alzheimer's Disease. AD patients with Pro/Ala genotype had disease onset 4.6 years earlier and significantly lower plasma sRAGE levels than carriers of Pro/Pro genotype.
19631630 Observational study of gene-disease association. (HuGE Navigator)
19627000 PPAR-gamma and COX-2 were both overexepressed in the skin lesions of condyloma acuminatum and bowenoid papulosis.
19625176 Observational study of gene-disease association. (HuGE Navigator)
19624894 HDAC suppresses the activation of PPARgamma in the gastric carcinoma cell line SGC-7901.
19622037 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19609844 Observational study of gene-disease association. (HuGE Navigator)
19602701 Meta-analysis and HuGE review of gene-disease association. (HuGE Navigator)
19596783 Menin is an important factor in PPARgamma-mediated adipogenesis.
19596656 Results identify TRIP3 as a novel regulator of PPARgamma-mediated adipocyte differentiation.
19592620 Observational study of gene-disease association. (HuGE Navigator)
19587357 Meta-analysis of gene-disease association. (HuGE Navigator)
19583951 PTIP controls expression of PPARgamma and C/EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.
19581903 Signaling via the canonical Wnt-beta-catenin pathway inhibits PPARgamma mRNA expression, whereas signaling via the noncanonical Wnt pathway results in activation of a histone methyltransferase SETDB1 that represses PPARgamma transactivation.
19578796 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19569080 In hypertensive patients, increased inflammatory cytokines were associated with increased incidence of atrial fibrillation and down-regulation of PPAR-gamma.
19563910 A specific induction of autophagy by PPAR gamma activation in breast cancer cells providing an understanding of distinct roles of PPAR gamma in tumorigenesis, is shown.
19560328 The PPARG gene has been reported to be strongly associated with type-2 diabetes, but the present study did not support the hypothesis that the PPARG gene may also play an important role in the development of schizophrenia.
19560328 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19558269 The Pro12Ala polymorphism in the PPARgamma2 gene is associated with obesity in Iranian subjects and the presence of the Ala allele could predict higher BMI.
19558269 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19549442 Pro12Ala and His447His polymorphisms of PPAR-gamma are associated with polycystic ovary syndrome.
19549442 Observational study of gene-disease association. (HuGE Navigator)
19548113 PPARG is a candidate gene for high-altitude adaptation in the Chinese Tajik population.
19548113 Observational study of gene-disease association. (HuGE Navigator)
19543210 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19540934 data suggest that, in oxidative stress-induced cardiomyocyte apoptosis, PPARgamma protects cells from oxidative stress through upregulating Bcl-2 expression
19536736 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19536733 The proline 12 alanine substitution in the PPARgamma2 gene is associated with increased extent of coronary artery disease in men
19536733 Observational study of gene-disease association. (HuGE Navigator)
19535643 Activation of PPARgamma leads to increased uptake and cross-presentation of ovalbumin but concomitantly impaired activation of CD8-positive T cells from T cell receptor-transgenic mice, due to increased signaling via coinhibitory molecule B7H1.
19534662 PPARgamma Pro12Ala SNP has no effect on the risk of developing lipodystrophy in HIV-1-infected patients treated with HAART
19534662 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19526109 The PPARG Pro12Ala polymorphism is associated with human motor activity.
19526109 Observational study of gene-disease association. (HuGE Navigator)
19524923 Carbon monoxide (from CORM-2) inhibits high glucose-induced ICAM-1 expression via AMP-activated protein kinase and PPAR-gamma activations in endothelial cells.
19506796 These results indicate that PPARc is involved in the molecular pathogenesis of Barrett's adenocarcinoma formation and growth
19506043 epistatic effects of five candidate genes, including ADIPOQ, ENPP1, GHSR, PPAR and TCF7L2, are significantly associated with the risk of DN amongst Taiwanese T2D individuals.
19506043 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19502414 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19500413 In the present study, there were no consistent associations between PPARgamma Pro12Ala and risk of acute coronary syndrome
19500413 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19495794 high expression level of PPARgamma significantly correlated with long-term survival of breast cancer.
19494505 These findings suggest that estradiol potentially upregulates eosinophil PPARgamma expression in vitro, although some other mechanisms might be involved in its regulation in vivo.
19491387 Severe obesity in Han Chinese was associated with 3 novel common SNPs for ESR1 and PPARgamma. These 2 genes collectively result in a >5-fold risk of severe obesity.
19491387 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19485965 Age-induced loss of PPARgamma/steroid receptor coactivator-1 interactions increased the binding of PPARgamma to the promoter of the adipogenic gene aP2.
19484168 PPARgamma C161T is associated with low peak bone mass.
19484168 Observational study of gene-disease association. (HuGE Navigator)
19479237 Observational study of gene-disease association. (HuGE Navigator)
19471887 Results suggest that PAR-1622 is a selective partial activator of PPARgamma and has excellent antihyperglycemic activities and a broad safety profile for fluid retention.
19470430 Data evidenced a significative correlation between both SREBP-1c and PPARgamma and EF and intramyocyte lipid accumulation.
19470259 PPAR-gamma and IL-13 might participate in the pathogenesis of acute ITP.
19465486 the Pro12Ala polymorphism in the PPARgamma2 gene is associated with decreased basic metabolic rate in women with polycystic ovary syndrome and biochemical hyperandrogenemia
19455305 Data found no convincing genetic link between type 1 and type 2 diabetes. An association of PPARG (rs1801282/Pro12Ala) could be consistent with its known function in inflammation.
19454659 pollen-derived PPE(1) modulate DC function via PPAR-gamma dependent pathways that lead to inhibition of NFkappaB activation and result in reduced dendritic cell IL-12P70 production and consecutive TH2 polarization
19453261 Observational study of gene-disease association. (HuGE Navigator)
19443733 Activation of PPARgamma by rosiglitazone attenuates intestinal Cl- secretion.
19438902 Circulating concentrations of osteoprotegerin are associated with abdominal aortic aneurysm and with one peroxisome proliferator-activated receptor gamma gene polymorphism.
19436234 Carriers of the G allele (Ala) of the Pro12Ala variant had a borderline increased relative risk of pancreatic cancer compared with homozygous carriers of the C allele (Pro).
19432669 PPARgamma immunoreactivity is considered to be a new clinicopathological parameter of human prostate cancer
19422369 P633H, a novel dual agonist at peroxisome proliferator-activated receptors alpha and gamma, with different anti-diabetic effects in db/db and KK-Ay mice.
19418728 The association of single and combined polymorphisms Gly972Arg, SNP43, & Pro12Ala, of the genes IRS1, CAPN10, PPARG2, respectively, with the risk of failure to sulphonylurea and metformin therapies was determined in patients with NIDDM.
19418728 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19405075 Stimulation with advanced glycation end products decreased endothelial PPAR-gamma expression in saphenous vein endothelial cells cultured from diabetic patients.
19395477 results indicate that PPAR-gamma blocked Smad-mediated transcriptional responses by preventing p300 recruitment and histone H4 hyperacetylation, resulting in the inhibition of TGF-beta-induced collagen gene expression
19395102 PPARdelta may serve as a more potent therapeutic target than PPARgamma in atherosclerosis or inflammatory therapy
19389254 biomarkers of placental CYP19 and PPARgamma gene expression show high within-placental variability.
19383491 These results suggest that PPARgamma transcriptionally induces IDE expression.
19380854 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19380830 Lack of PPARgamma in alveolar macrophages of transgenic mice disrupts lung homeostasis and results in a T helper cell (Th)1-like inflammatory response with up-regulation of inducible nitric oxide synthase and other inflammatory mediators in the lung.
19376812 The PPARG pathway is dysregulated in frataxin deficient mice and Friedreich's ataxia patients.
19367093 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19358337 Peroxisome proliferator activated receptor gamma (PPARgamma) enhanced MHC II activation and COL1A2 repression by IFN-gamma while rescuing the antagonism by TGF-beta in a CIITA-dependent manner in human aortic smooth muscle cells.
19346318 PPARgamma is activated in cigarette smoking-related lung cancer
19345798 decreased the production of matrix metalloproteinases, intracellular adhesion molecule-1, and vascular cell adhesion molecule-1 in a pulpal inflammation
19342081 Findings may suggest that enhanced expression of PPARgamma in abortive extravillous trophoblasts may be one factor linked to miscarriage.
19338578 Report inhibition of human insulin gene transcription by peroxisome proliferator-activated receptor gamma and thiazolidinedione oral antidiabetic drugs.
19324937 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19303976 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19283612 Evaluation of PPAR gamma and delta expression is useful for predicting postoperative mortality in patients undergoing colorectal cancer surgery.
19282863 Observational study of gene-disease association. (HuGE Navigator)
19279199 Report PPAR/RXRalpha dysregulation in preterm and infection-driven infection labor.
19279076 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19267951 Mediterranean diet seems to be able to reduce waist circumference in a high-cardiovascular risk population, reversing the negative effect that the 12Ala allele carriers of the PPARgamma gene appears to have.
19267951 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19267370 Observational study of gene-disease association. (HuGE Navigator)
19263529 Observational study of gene-disease association. (HuGE Navigator)
19254215 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19247372 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19237017 C1431T, but not Pro12Ala polymorphisms of PPARgamma gene, are associated with metabolic syndrome (MS) in a Chinese population. In MS patients, Ala allele and T allele are both associated with higher fasting blood sugar and higher left ventricular voltage
19237017 Observational study of gene-disease association. (HuGE Navigator)
19228871 Carriers of the 12Ala allele of PPARgamma have less widespread coronary artery disease and are protected against 10-year (cardio)vascular morbidity and mortality.
19228871 Observational study of gene-disease association. (HuGE Navigator)
19225884 Simvastatin, pravastatin, and NO-pravastatin increased expression of the proteins PPARalpha, PPARgamma, and ABCA1, and expression of the mRNA of ABCA1 and LXRalpha in GBEC.
19225753 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19223982 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19217272 The frequency of PPARG-ht2 was significantly lower in the patients with asthma while the frequency of PPARG-ht1 was significantly higher in the patients with asthma compared to the normal controls
19217272 Observational study of gene-disease association. (HuGE Navigator)
19208777 Observational study of gene-disease association. (HuGE Navigator)
19201410 PPARg, PPARd and LXRa are involved in the regulation of ABCA1 expression and HDL biogenesis in a cooperative signal transduction pathway
19199260 Pro12Ala variant of the PPAR gamma was associated with rheumatoid arthritis.
19199260 Observational study of gene-disease association. (HuGE Navigator)
19193378 the PPARgamma-dependent PI3K/Akt pathway has a role in telmisartan-induced proliferation of human endothelial progenitor cells
19193342 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19188432 The PPARgamma2 Alanine-12 allele is associated with an increased growth rate in early life. This effect may be influenced by breast-feeding duration.
19188432 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19186181 Tumor expression of PPARG is independently associated with longer survival of patients. PPARG expression appears to mark an indolent subset of colorectal cancers.
19179433 PPARgamma represses human SHBG expression in liver cells.
19178525 The PPARgamma Pro12Ala Pro/Pro and resistin SNP-420 G/G genotypes were associated with plasma resistin in the Japanese population.
19178525 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19170196 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
19157507 Peroxisome proliferator-activated receptor expression in effusions from ovarian carcinomais associated with poor response to chemotherapy at disease recurrence and poor survival
19156545 results indicate that the stimulation of scavenger receptor class B type I(SR-B1) expression in the liver is mediated in part by activation of the peroxisome proliferator-activated receptor gamma and retinoid X receptor using thiazolidinediones
19148128 Observational study of gene-disease association. (HuGE Navigator)
19147680 The Y473A mutant is selectively stimulated by telmisartan but not TZDs, suggesting that telmisartan and TZDs have differential effects on the transcriptional control.
19141539 The present data indicate that down-regulation of MMP and proteasome activities constitutes a novel mechanism of PPAR-induced protections against HIV-induced disruption of brain endothelial cells.
19139842 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19131662 Meta-analysis of gene-disease association. (HuGE Navigator)
19130493 decrease in lipid accumulation in apoE-transfected cells was associated with a strong downregulation of PPARs gamma1 and gamma2 and stearoyl-CoA desaturase 1.
19126543 a composite enhancer binding both PPARgamma and C/EBPa,b factors confers adipocyte-specific expression to Retn in mouse, and its absence from the human gene may explain the lack of adipocyte expression in humans.
19125195 Results show that a novel nucleotide variant A-2819G, in the regulatory region of PPARG, is associated with type 2 diabetes and with proliferative retinopathy in females in an Italian cohort.
19125195 Observational study of gene-disease association. (HuGE Navigator)
19121846 reduced expression of beta-catenin and peroxisome proliferator-activated receptor-gamma could play a key role in aggressive colorectal cancer behavior.
19117570 PPARgamma promoter polymorphisms have roles in acute coronary syndrome
19117570 Observational study of gene-disease association. (HuGE Navigator)
19116451 CD36 signaling may inhibit stress- induced gene expression by suppressing translation via activation of PPARgamma in monocytes.
19104705 We observed no significant differences in the frequency of the Pro12Ala polymorphism in the PPAR-gamma gene among subjects with CD, UC and controls (15.9%, 15.5% and 13%, respectively, p>0.05).
19104705 Observational study of gene-disease association. (HuGE Navigator)
19101554 The 1.9A crystal structure ofPPARgamma C285S mutant LBD, which is bound to 15d-PGJ2 in the covalent modification-independent manner was determined.
19088437 The effect of LDL particles showing extensive or low oxidation (HoxLDL and LoxLDL) on the expression of CD36 and FcgammaRII in a human monocytic cell line and the involvement of PPARgamma, was investigated.
19081837 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
19073146 ASF/SF2 and PPAR-gamma determines the ratio of UCP3 isoforms.
19070258 the presence of the Ala allele at the PPARG/Pro12Ala polymorphism and the Ser allele at the PPARGC1A/Gly482Ser polymorphism may be a predisposing factor for sarcoidosis.
19070258 Observational study of gene-disease association. (HuGE Navigator)
19064572 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
19061500 increase in PPARgamma1 signaling observed in breast cancer contributes to an imbalance between proliferation and apoptosis, and may be an important hallmark of breast tumorigenesis
19059241 CDX1 enhanced the expression of PPARgamma gene, a master transcriptional regulator of intestinal differentiation, at the transcriptional level, via functional interaction with CCAAT/enhancer-binding protein alpha (C/EBPalpha).
19056576 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19056482 Observational study of gene-disease association. (HuGE Navigator)
19053776 analysis of the crystal structure of the peroxisome proliferator-activated receptor gamma (PPARgamma) ligand binding domain
19052558 PPARgamma is crucial for healthy pilosebaceous units and it is the loss of this function that triggers the pathogenesis of scarring alopecia and lichen planopilaris.
19043829 structures of intact PPAR-gamma and RXR-alpha as a heterodimer bound to DNA, ligands and coactivator peptides
19035184 PPARgamma gene C161-->T should be associated with body mass index, waist width and hip width
19028452 The discovery of PPARgamma as a component of human plasma exosomes identifies a potential new pathway for the paracrine transfer of nuclear receptors
19020324 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
19020323 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19020036 LMO4 protects neurons from ischemic brain injury, in part through its requirement as an essential cofactor of PPAR gamma
19018532 these findings support a regulatory role for PPARgamma in the proliferation, survival and differentiation of malignant B cells.
19016747 Inhibition of PPARgamma activity suppresses pancreatic cancer cell motility.
19002430 Observational study of gene-disease association. (HuGE Navigator)
19000312 There were no associations between low birth weight and blood lipids in any of the PPARgamma2 genotypes.
19000312 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18997828 Observational study of gene-disease association. (HuGE Navigator)
18996470 An assay using unlabeled probes and the LightCycler or Rotor-Gene instruments was developed for genotyping of PPARG, PPARGC1A and transcription factor 7-like 2 (TCF7L2) polymorphisms.
18996470 Observational study of genetic testing. (HuGE Navigator)
18996102 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18992263 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18992148 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18984664 Observational study of gene-disease association. (HuGE Navigator)
18977277 This population-based study demonstrates that the Pro12Ala polymorphism resulting in an amino acid exchange in the N-terminal sequence of PPARgamma may influence the onset of MS.
18977277 Observational study of gene-disease association. (HuGE Navigator)
18977231 Four crystal structures of the PPARgamma ligand binding domain (LBD) covalently bound to endogenous fatty acids via a unique cysteine, which is reportedly critical for receptor activation, are presented.
18972257 Four candidate polymorphisms in the three genes TCF7L2 (rs12255372 and rs7903146), PPARG (rs1801282), KCNJ11 (rs5219) and traditional risk factors were studied
18959602 Observational study of gene-disease association. (HuGE Navigator)
18936436 Observational study of genotype prevalence. (HuGE Navigator)
18936159 The antioxidant effect of PPARgamma is exclusively mediated by GPx3 and further imply that GPx3 may be a therapeutic target for insulin resistance and diabetes mellitus.
18931513 interaction between AngII and osteoprotegerin in aneurysm formation. Activation of PPARgamma may have a role in treatment of abdominal aortic aneurysm (AAA).
18927468 Circulating angiogenic cells in diabetic angiopaathy is a multistage process requiring sequential activation of transcriptional factors, including STAT5 and PPARG.
18927280 PPARgamma negatively controls multiple myeloma growth and viability in part through inhibition of interleukin-6 production by bone marrow stromal cells.
18855061 This study confirms the association of PPARgamma with morbid obesity.
18845641 HO-1 as a negative regulator of trophoblast motility acting via up-regulation of PPARgamma.
18836859 Human PPAR-gamma plays a critical physiological role as a central transcriptional regulator of both adipogenic and lipogenic programs. Its transcriptional activity is induced by the binding of endogenous and synthetic lipophilic ligands. [review]
18832723 apoptotic cells induce PPARgamma sumoylation to attenuate the removal of NCoR, thereby blocking transactivation of NF-kappaB.
18828733 Observational study of gene-disease association. (HuGE Navigator)
18823720 Observational study of gene-disease association. (HuGE Navigator)
18822908 PPAR-gamma mRNA expression in coronary heart disease patients were higher than in the normal patients.
18809223 ApoC-IV overexpression may perturb lipid metabolism leading to lipid accumulation. HCV core protein may modulate ApoC-IV expression through Ku antigen and PPARgamma/RXRalpha complex.
18789822 PPARgamma and TP53 genes may be candidates for molecular markers in pediatric MDS, and that these potentially recurrent deletions could contribute to the identification of therapeutic approaches in primary pediatric MDS
18789607 Peroxisome proliferator-activated receptor-gamma is frequently over-expressed in androgen independent prostate cancer cell lines and human prostate cancer tissues
18789381 Observational study of gene-disease association. (HuGE Navigator)
18786524 Observational study of gene-disease association. (HuGE Navigator)
18777501 Despite the high frequency of the Ala allele at the PPAR-gamma2 gene in our population of Polish men, the Ala12 allele does not appear to improve insulin sensitivity or have an influence on the occurrence of obesity.
18777501 Observational study of gene-disease association. (HuGE Navigator)
18757431 findings identify a novel CREB3L2-PPARgamma gene fusion mutation in thyroid carcinoma and reveal a thyroid signaling pathway that is regulated by intramembrane proteolysis and disrupted in cancer
18756295 review of expression and functions of klotho and the upregulation of klotho by PPARG
18755275 findings suggest lowered brain weight of PKU patients may thus be the result of reduced neuroblast proliferation caused by phenylalanine-induced stimulation of PPARgamma receptors
18753860 Observational study of gene-disease association. (HuGE Navigator)
18727927 PAR-5359, a well-balanced PPARalpha/gamma dual agonist, exhibits equivalent antidiabetic and hypolipidemic activities in vitro and in vivo.
18724972 Observational study of gene-disease association. (HuGE Navigator)
18718916 PPARgamma regulates pdx-1 transcription in beta-cells
18713822 Lipodystrophic PPARG P467L phenotype includes excessive and uncontrolled generation of non-esterified fatty acids directly from triglyceride-rich lipoproteins.
18711014 Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway
18710415 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
18710329 Observational study of gene-disease association. (HuGE Navigator)
18707223 These findings suggest that dietary fat has a significant influence on bone mineral density that is dependent on the alleles present for the PPARG gene.
18697866 Changed expression of downstream PPARgamma targets after stearoyl CoA desaturase (SCD) knockdown suggests that PPARgamma up-regulation of SCD leads to increased lipogenesis and potentiation of adiponectin signaling.
18688583 PPAR gamma rearrangements can detect a subset of follicular-patterned thyroid carcinomas in preoperative thyroid fine-needle aspiration biopsies
18688264 FOXA1 and IRF-1 intermediary transcriptional regulators of PPARgamma-induced urothelial cytodifferentiation
18683148 Observational study of gene-disease association. (HuGE Navigator)
18680073 Alterations in inflammatory serum markers appear Ato be a feature of polycystic ovary syndrome, and are independent of PPAR gamma variants.
18680073 Observational study of gene-disease association. (HuGE Navigator)
18676870 Observational study of gene-disease association. (HuGE Navigator)
18676680 Observational study of gene-disease association. (HuGE Navigator)
18676352 Endothelial PPAR gamma is a critical mediator of vascular function; its loss through dominant-negative interference in the aorta of transgenic mice causes endothelial dysfunction through a mechanism involving oxidative stress.
18660489 Observational study of gene-disease association. (HuGE Navigator)
18657335 PPARgamma amino acid sequencqe allele may confer protection against overweight in the Tunisian population.
18657264 We didn't find evidence of interaction between PPARD and PPARG. No association was observed for analysed polymorphisms at CAPN5 or PPARG genes.
18645733 Genetic variants in PPARG and ADIPOQ candidate genes for insulin resistance are associated with cholesterol levels in obese children and adolescents, and may offer additional information in the risk assessment of obese children
18645733 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18645029 The effect of XIAP inhibition and PPARgamma activation in colon cancer, was explored.
18639367 although the PPAR gamma Ala variant is associated with a reduced risk of type 2 diabetes, it may increase the risk of cognitive impairment in individuals once diabetes has developed.
18639367 Observational study of gene-disease association. (HuGE Navigator)
18634911 A functional role of PPARgamma/RXRalpha and Oct-1 in the regulation of the FABP2 gene.
18624999 The Pro(12)Ala PPAR gamma gene polymorphism is equally present in patients with Graves' disease with or without thyroid-associated orbitopathy (TAO). Among patients with TAO this polymorphism is associated with less-severe and less-active disease.
18624999 Observational study of gene-disease association. (HuGE Navigator)
18608213 Conclude that PPARgamma activation is essential to elicit the anti-carcinogenic action of herbal isoprenols in colonic cancer cells.
18604218 analysis of the molecular basis of PPAR gamma discrimination of various naturally occurring fatty acid derivatives
18598350 PPARG2 SNPs revealed a significant association with type 2 diabetes
18598350 Observational study of gene-disease association. (HuGE Navigator)
18597214 Gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population.
18597214 Observational study of gene-disease association. (HuGE Navigator)
18593980 Jab1 is overexpressed in HCC and PPARgamma ligands may suppress Jab1 to inhibit the proliferation of HCC cells
18591388 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18579355 The anticancer effects of ciglitazone may not depend solely on PPARgamma activation.
18578080 altered activity of PPARgamma2 may correlate with decreased PPAR-mediated signaling
18573313 PPARG gene does not play a major role in the genetic predisposition to AD in the Finnish population.
18573313 Observational study of gene-disease association. (HuGE Navigator)
18561518 Report does not support a role for PPARG P12A polymorphism in future risk of acute myocardial infarction, coronary heart disease or ischemic stroke.
18561518 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18556801 PPARgamma inhibits the inflammatory response in CF, at least in part by interaction with NF-kappaB in airway epithelial cells. PPARgamma agonists may be therapeutic in CF.
18555503 7-hydroxyandrosterone decreased the expression of PPARG.
18551086 menopausal women with the Pro/Ala PPAR gamma (peroxisome proliferator-activated receptor gamma)genotype had a higher BMI, waist-to-hip ratio, and fasting glucose than the group with the Pro/Pro genotype
18551086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18547997 a noncanonical PPAR-responsive element within the 5'-flanking region of the human klotho gene
18544633 PPARgamma accelerates cellular senescence; phosphorylation of PPARgamma decreased with increased cell passage
18538667 The Ala12 allele of PPAR-gamma2 is associated with lower levels of soluble RAGE and the presence of peripheral arterial disease.
18538667 Observational study of gene-disease association. (HuGE Navigator)
18535203 Inhibition of chemotaxis by PPAR-gamma ligands correlated with decreases in extracellular signal-regulated kinase-1 and -2 activation, actin polymerization, and adherence to a fibrinogen substrate.
18516622 Observational study of gene-disease association. (HuGE Navigator)
18516296 analysis of a novel sequence-specific synergy between PPAR-gamma ligands and chemotherapeutic agents for lung cancer treatment
18513389 Observational study of gene-disease association. (HuGE Navigator)
18509005 crucial role exerted by p21Cip1/WAF1 in PPARgamma action in thyroid neoplasm
18507082 Research suggests that Plo12Ala polymorphism of proliferator-activated receptor gamma may not be assocationed with the risk of developing ulcerative colitis in Japanese population.
18507082 Observational study of gene-disease association. (HuGE Navigator)
18498634 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18496506 BMP-7 ameliorates IgA nephropathy-derived polymeric IgA-induced TNF-alpha and TGF-beta synthesis in human mesangial cells through multiple mechanisms involving inhibitory Smads and PPAR-gamma.
18490773 findings show that a defective CFTR induces up-regulation of tissue transglutaminase (TG2) in tissues & cell lines; increased TG2 activity leads to functional sequestration of PPARgamma & increase of the classic parameters of inflammation
18483152 The human renin Pal3 site appears to be critical for the PPARgamma-dependent regulation of gene expression.
18469005 the strong interaction of PGC-1alpha and PPARgamma is mediated through both hydrophobic and specific polar interactions.
18467141 The Ala-allele is associated with enhanced decline in GFR and predicts ESRD and all-cause mortality in patients with nephropathy.
18467141 Observational study of gene-disease association. (HuGE Navigator)
18466209 Variation in the PPARG locus may influence disease progression during the first year after the presentation of T1D.
18466209 Observational study of gene-disease association. (HuGE Navigator)
18465691 Activation of receptors by specific ligands of PPARgamma induces inhibition of cell proliferation, induction of apoptosis and terminal differentiation as well as inhibition of angiogenesis.
18451773 Observational study of gene-disease association. (HuGE Navigator)
18450755 syndecan 1 is up-regulated by n-3 fatty acids by a transcriptional pathway involving PPARgamma
18443916 Data show that of four genes studied -- angiotensin-forming enzyme, PON1, PPAR-gamma, and APOE -- only PPAR-gamma and APOE showed an effect on fertility.
18443916 Observational study of gene-disease association. (HuGE Navigator)
18435931 Cell-specific expression patterns of multiple PPARG transcript variants encoding for the same protein but differing in mRNA stabilities enable a fine-tuning of PPARG action.
18426866 Observational study of gene-disease association. (HuGE Navigator)
18426861 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18424599 data provide evidence that Alanine 12 sequence variant is associated with a worse metabolic profile than Proline 12 and is related to differences in expression of peroxisome proliferator-activated receptor gamma and oxidative imbalance after fat overload
18424599 Observational study of gene-disease association. (HuGE Navigator)
18417957 We conclude that P12A and C161T polymorphisms of the PPAR-gamma gene are important predictors of cardiovascular event in patients with diabetic nephropathy.
18417957 Observational study of gene-disease association. (HuGE Navigator)
18413760 n-3 polyunsaturated fatty acids (n-3 PUFA) upregulate syndecan 1 in breast cancer cellsbu activating PPARgamma, providing a chemopreventive effect.
18411276 Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells
18398047 Observational study of gene-disease association. (HuGE Navigator)
18391483 Peroxisome proliferator-activated receptor gamma suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor pathway.
18388889 In whites from Italy the PPARgamma2 Pro12Ala polymorphism interacts with gender in modulating BMI, thereby replicating some, but not all, earlier data obtained in different populations.
18388889 Observational study of gene-disease association. (HuGE Navigator)
18388689 polymorphisms in peroxisome proliferator-activated receptors are critical susceptibility risk factors for dyslipidemias and diabetes [review]
18382765 Results describe an antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.
18381063 DAX-1 acts as a corepressor of PPARgamma and performs a potential function in the regulation of PPARgamma-mediated cellular differentiation.
18379566 The PPAR gamma Pro12Ala and C1431T polymorphisms are associated with increased adiposity during early childhood in a gender- and age-specific manner and independently of the PPAR delta T+294C polymorphism
18379566 Observational study of gene-disease association. (HuGE Navigator)
18372284 Analysis of PPARG polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease is reported.
18372284 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18370824 Observational study of gene-disease association. (HuGE Navigator)
18362424 Association of peroxisome proliferator-activated receptor gamma gene Pro12Ala and C161T polymorphisms with metabolic syndrome and insulin resistance.
18362424 Observational study of gene-disease association. (HuGE Navigator)
18346728 SPPARgammaM5 was a potent partial agonist of human PPARgamma .
18317437 PPARgamma plays an important role in controlling cell differentiation and PPARgamma ligands can modify inflammatory and fibrotic responses in pulmonary fibrosis
18317436 In many tumor cells, including lung carcinoma cells, activation of PPARgamma results in decreased cellular proliferation
18317435 observations point to PPAR-gamma in the context of the alveolar macrophage as a crucial factor in limiting excessive and possibly injurious inflammation in the lung
18317434 Peroxisome proliferator-activated receptor gamma is expressed in the lung and pulmonary vasculature, and its expression is reduced in the vascular lesions of patients with pulmonary hypertension
18316027 Identify PPARgamma as pivotal in vascular muscle as a regulator of vascular structure, vascular function, and blood pressure.
18313368 Current findings of PPARalpha and gamma open up the possibility of developing new therapeutic agents that modulate these nuclear receptors to control various inflammatory diseases.
18313022 Observational study of gene-disease association. (HuGE Navigator)
18293083 we reported for the first time that PPARgamma directly activates FasL promoter gene inducing apoptotic events in breast cancer cells.
18292390 There is a novel mechanism via CXCR2 induction by PPAR-gamma that can enhance the immune response in human macrophages.
18288282 Observational study of gene-disease association. (HuGE Navigator)
18282590 Observational study of gene-disease association. (HuGE Navigator)
18280041 This sample did not replicate the direct association of the PPARG Pro12Ala allele with diabetes status or preserved cognitive function. The data did suggest that risk of cognitive decline is greater when Pro12Ala carriers contract diabetes.
18280041 Observational study of gene-disease association. (HuGE Navigator)
18271689 The metabolic effects of 12Ala carriership were influenced by free fatty acids levels - the beneficial role of 12Ala was seen only in the presence of low concentration of plasma free fatty acids
18271689 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18268966 Observational study of gene-disease association. (HuGE Navigator)
18268966 Pro 12Ala polymorphism of PPARgamma2 gene is associated with increase of the body mass index in patients with metabolic syndrome X.
18268046 PPAR alpha and PPAR gamma activation stimulates neoangiogenesis in umbilical veins through a VEGF-dependent mechanism.
18263601 Observational study of gene-disease association. (HuGE Navigator)
18250615 Observational study of gene-disease association. (HuGE Navigator)
18250615 Regression analysis confirmed the association of the Pro12Ala mutation of the PPARgamma gene with normal but not with overweight/obesity among Type 2 diabetes patients.
18247297 The PPARgamma2 promoter -689C/T polymorphism is associated with an increased risk of MI.
18247297 Observational study of gene-disease association. (HuGE Navigator)
18242157 15d-PGJ2 and ciglitazone down-regulate TNF-alpha-mediated osteoclast differentiation in human cells, in part via suppression of the action of MCP-1
18241614 genetic variation at the PPARG loci may confer higher cardiovascular disease risk in patients with type 2 diabetes mellitus
18234854 involvement of PPARgamma1 in a myriad of physiological processes further confirms that microflora-driven regulation might be important for a number of homeostatic strategies in the gut
18217139 PPARgamma/retinoid X receptor complex released from activated platelets in microparticles was internalized by a monocytic cell line.
18214615 The RNAi approach using shRNA-expressing plasmid suppresses PPAR-gamma expression in HCT-116 cells and PPAR-gamma gene silencing promotes proliferation of CRC cells.
18211635 Hypothesized interaction between cod liver oil and PPARG2 polymorphism in reducing type 1 diabetes risk is not supported.
18211635 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
18209083 PPARgamma stimulation prevented activation of two GTPases, Rac1 and RhoA, which correlated with decreased monocyte adhesion to and migration across brain endothelium.
18204896 the ERalpha signalling pathway is disrupted by PPARgamma agonists
18204431 the presence of PPAR-gamma staining can aid in the diagnosis of dedifferentiated liposarcoma
18203887 This study was conducted to determine whether PPARgamma1 serves as a molecular link between the physiological actions of eicosapentaenoic acid (EPA) in human colon cancer cells (HT-29).
18202670 novel amplification cycle in which PPAR-gamma activation induces production of 12- and 15-LO-derived metabolites which in turn feed back to upregulate PPAR-gamma-2's own expression
18198294 There is a combined effect of DIO2 T92A and PPARgamma2 P12A polymorphisms on insulin resistance-related features in non-diabetic whites.
18198294 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18187557 PPAR-gamma polymorphisms and their interaction with smoking may contribute to the etiology of lung cancer
18187557 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18182855 the examined polymorphisms and haplotypes of the PPARgamma gene are unlikely to be associated with susceptibility to osteonecrosis of the femoral head.
18182855 Observational study of gene-disease association. (HuGE Navigator)
18182682 review of role of activation of PPARalpha, -beta/delta, or -gamma or LXRs in skin physiology and cytology and disease
18172578 Both mouse and human melanoma cells produced more PPARalpha and PPARgamma protein compared to melanocytes.
18164040 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18162503 Variation in PPARG2 and HNF4A may interact to regulate insulin sensitivity in Mexican Americans at risk for type 2 diabetes.
18162503 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18160840 Observational study of gene-disease association. (HuGE Navigator)
18160010 HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells
18159845 Observational study of gene-disease association. (HuGE Navigator)
18159845 The TNFalpha concentration in serum and the TNFalpha gene expression in monocytes do not refer to the Pro12ala polymorphism of PPARgamma in patients with type 2 diabetes. 2) The Pro12Ala genotype do not influence autoimmunologic processes of diabetes.
18158351 Transfection of CD4-positive lymphocytes with PPARgamma small interfering RNA abolished telmisartan's effect on migration, whereas blockade of the AT1R had no such effect.
18096664 HIV-1 Tat-interacting protein 60 (Tip60) as a novel positive regulator of PPARgamma transcriptional activity.
18091023 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18091023 The researchers found that the rs17036314, rs1801282, and rs1152003 alleles were associated with an increased risk of type 2 diabetes mellitus but lifestyle changes in the rs1152003 group modified risk.
18082740 PPARgamma plays a negative role by directly acting on Smad and ERK phosphorylation in human endometrial cellt reated with TGF-beta1.
18077140 PPAR gamma regulates involucrin expression by controlling the AP-1 signal and p38 activation in 1 alpha,25(OH)2D3-induced keratinocyte differentiation.
18077048 alanine variant of the Pro12Ala polymorphism of PPARgamma might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
18055759 Antineoplastic effects of PPARgamma in non-small-cell lung neoplasms are mediated by suppression of COX-2 via inhibition of NF-kappaB.
18004978 PPARalpha,gamma DNA methylation induced by Hcy may represent an important mechanism to explain atherosclerosis.
17999673 Single nucleotide polymorphismss in the PPAR-gamma, but not PGC-1alpha, gene are associated with non-alcoholic fatty liver disease susceptibility possibly through the adiponectin pathway.
17999673 Observational study of gene-disease association. (HuGE Navigator)
17999084 Observational study of gene-disease association. (HuGE Navigator)
17998334 Parvin-beta might influence breast cancer progression
17994213 PPARG and KCNJ11 variants that are known to influence individual predisposition to type 2 diabetes do not appear to have pleiotropic effect on early growth
17994213 Observational study of gene-disease association. (HuGE Navigator)
17985660 Observational study of gene-disease association. (HuGE Navigator)
17985660 results provide further support of the association between the PPARG2 Ala12 allele and risk of overweight or obesity in Mestizos and two Amerindian populations from Mexico
17980149 (NMR) study on the GW1929-bound peroxisome proliferator-activated receptor gamma (PPARgamma) ligand-binding domain (LBD)
17941898 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
17941898 Suggest that PPAR-g Pro12Ala may affect blood lipid levels and the abdominal fat storage of diabetic Ugyurs and Kazaks and may be associated with fat storage and insulin resistance in Hans.
17937104 exposure of BAL cells or purified alveolar macrophages to IFN-gamma resulted in dose-dependent repression of PPARgamma mRNA in both sarcoidosis and controls.
17932108 Data show that PPARgamma-mediated gene transcription was repressed by Vpr produced as a consequence of direct infection of adipocytes and in turn suppress differentiation of preadipocytes.
17929009 analysis of ligand-escape pathways from the ligand-binding domain of PPARgamma receptor
17928738 the results confirmed involvement of the PPARgamma pathway in nonalcoholic steatohepatitis
17926914 Observational study of gene-disease association. (HuGE Navigator)
17921408 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17921408 The protective effect of polyunsaturated fat intake on myocardial infarction is attenuated in carriers of the Ala12 allele of PPARG
17903300 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
17902047 These findings help to define the molecular mechanism driving the high expression of PPARgamma1 in breast cancer and raise new questions regarding the role of MAZ in cancer progression.
17898990 Clinical trial of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17896990 PPARgamma receptors possess evident tumor promoting properties but in this review, the receptor independent effects of its ligands compound the understanding of its biology in cancers.
17892998 Observational study of gene-disease association. (HuGE Navigator)
17892998 PPAR gamma C161T polymorphism was associated with coronary artery disease (CAD) in a Chinese population. T allele of the PPAR gamma gene might have a protective effect on the progression of CAD and reduce the onset of acute coronary syndrome.
17890503 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17884443 Observational study of gene-disease association. (HuGE Navigator)
17884443 polymorphism in the PPARgamma2 gene was positively associated with an enlarged area of small dense low-density lipoprotein 4-7
17874829 Observational study of gene-disease association. (HuGE Navigator)
17874829 all variables related to obesity showed a higher trend in Pro12Ala heterozygous subjects compared to Pro12Pro homozygous subjects; Pro12Ala heterozygous subjects showed an increasing trend of elevated blood pressure compared to Pro12Pro homozygotes
17870167 PEDF induces macrophage apoptosis and necrosis through the signaling of PPARgamma.
17868335 Reprot the cytoprotective effect of tauroursodeoxycholate on hepatocyte apoptosis induced by peroxisome proliferator-activated receptor gamma ligand.
17852881 Observational study of gene-disease association. (HuGE Navigator)
17805473 In this study, no association is seen between the Pro12Ala polymorphism in PPAR gamma 2 gene and the type 2 diabetes in Qatar.
17805473 Observational study of gene-disease association. (HuGE Navigator)
17805195 Observational study of gene-disease association. (HuGE Navigator)
17805195 Small body weight at birth may program lower fat-free mass in adolescents carrying the Ala12 allele in the PPARgamma-2 gene.
17803977 in neuronal cultured cells, the Pro12Ala substitution does not affect the anti-amyloidogenic capacity of PPAR-gamma
17785925 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17785633 We found that PPARgamma targets a palindromic repeat with a 3-bp spacer (Pal3) in the proximal human renin promoter. Renin is the first gene described with a functional Pal3 sequence. PPARgamma agonists also stimulated renin gene expression.
17785586 PPARgamma agonists have diverging and overlapping mechanisms blocking transactivation of transcription factors NF-kappaB and C/EBPbeta.
17766367 A new loss-of-function PPARG mutation, D424N, located in the ligand-binding domain of the protein, leads to familial partial lipodystrophy.
17765929 PPAR-gamma expression is enhanced in monocytes and macrophages from healthy smokers