| Tchem | Peroxisome proliferator-activated receptor delta |
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Comments
Property Summary
| Ligand Count | 353 |
| NCBI Gene PubMed Count | 292 |
| PubMed Score | 327.18 |
| PubTator Score | 507.40 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Obesity | 678 | 3.886 | 1.9 |
| Cardiomegaly | 116 | 0.0 | 0.0 |
| Cardiomyopathies | 110 | 0.0 | 0.0 |
| Fatty Liver | 70 | 0.0 | 0.0 |
| Liver Diseases, Alcoholic | 4 | 0.0 | 0.0 |
| Melanoma | 711 | 0.0 | 0.0 |
| Non-alcoholic Fatty Liver Disease | 42 | 0.0 | 0.0 |
| Peripheral Nervous System Diseases | 52 | 0.0 | 0.0 |
| Skin Neoplasms | 69 | 0.0 | 0.0 |
| Weight Gain | 100 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Bipolar Disorder | 666 |
| Peripheral Neuropathy | 134 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 5.0e-06 |
| ovarian cancer | 8520 | 1.4e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 2.4e-03 |
| psoriasis | 6694 | 9.8e-03 |
| astrocytoma | 1146 | 4.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.100 | 4.6e-02 |
| intraductal papillary-mucinous carcinoma... | 1.500 | 2.4e-03 |
| medulloblastoma, large-cell | -1.900 | 5.0e-06 |
| ovarian cancer | 1.500 | 1.4e-05 |
| psoriasis | 1.100 | 9.8e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA |
tretinoin
pKd 7.80
CHEMBL1760427
pIC50 7.00
CHEMBL2413326
pIC50 7.00
CHEMBL1081964
pEC50 7.00
CHEMBL604959
pIC50 7.00
CHEMBL393765
pIC50 7.01
CHEMBL200495
pIC50 7.02
CHEMBL367311
pKi 7.03
CHEMBL207442
pIC50 7.03
CHEMBL2413325
pIC50 7.04
CHEMBL393373
pIC50 7.04
CHEMBL477312
pEC50 7.05
CHEMBL39687
pIC50 7.05
CHEMBL37495
pIC50 7.05
CHEMBL288341
pEC50 7.05
CHEMBL234661
pIC50 7.05
CHEMBL387203
pEC50 7.05
CHEMBL207103
pIC50 7.06
CHEMBL391068
pIC50 7.09
CHEMBL234800
pIC50 7.09
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSL 1 - 70 NMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSH 71 - 140 NAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAP 141 - 210 FVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVT 211 - 280 LLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLAL 281 - 350 FIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI 351 - 420 KKTETETSLHPLLQEIYKDMY 421 - 441 //
