| Tbio | Suppressor of SWI4 1 homolog |
May have a role in cell growth.
This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear. [provided by RefSeq, Nov 2010]
This locus represents naturally occurring read-through transcription between the adjacent PPAN and P2RY11 genes. Alternative splicing results in two transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. This transcript is found to be ubiquitously expressed and is up-regulated by agents inducing granulocytic differentiation. However, its functional significance in vivo remains unclear. [provided by RefSeq, Nov 2010]
Comments
| Disease | Target Count |
|---|---|
| Narcolepsy | 69 |
| PMID | Text | |
|---|---|---|
| 22174317 | HIV-1 Rev interacting protein, PPAN-P2RY11 read through, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with PPAN-P2RY11 is increased by RRE |
MGQSGRSRHQKRARAQAQLRNLEAYAANPHSFVFTRGCTGRNIRQLSLDVRRVMEPLTASRLQVRKKNSL 1 - 70 KDCVAVAGPLGVTHFLILSKTETNVYFKLMRLPGGPTLTFQVKKYSLVRDVVSSLRRHRMHEQQFAHPPL 71 - 140 LVLNSFGPHGMHVKLMATMFQNLFPSINVHKVNLNTIKRCLLIDYNPDSQELDFRHYSIKVVPVGASRGM 141 - 210 KKLLQEKFPNMSRLQDISELLATGAGLSESEAEPDGDHNITELPQAVAGRGNMRAQQSAVRLTEIGPRMT 211 - 280 LQLIKVQEGVGEGKVMFHSFVSKTEEELQAILEAKEKKLRLKAQRQAQQAQNVQRKQEQREAHRKKSLEG 281 - 350 MKKARVGGSDEEASGIPSRTASLELGEDDDEQEDDDIEYFCQAVGEAPSEDLFPEAKQKRLAKSPGRKRK 351 - 420 RWEMDRGRGRLCDQKFPKTKDKSQGAQARRGPRGASRDGGRGRGRGRPGKRVA 421 - 473 //
| PMID | Year | Title | |
|---|---|---|---|
| 24204295 | 2013 | Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic. | |
| 23128233 | 2012 | Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. | |
| 20967262 | 2010 | Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15057824 | 2004 | The DNA sequence and biology of human chromosome 19. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12429849 | 2002 | Functional proteomic analysis of human nucleolus. | |
| 12077223 | 2002 | Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes. | |
| 11278528 | 2001 | Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. | |
| 10944437 | 2000 | Cloning, genomic organization, and tissue distribution of human Ssf-1. | |
| 9405388 | 1997 | Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. |
