Tdark POU5F2 POU domain, class 5, transcription factor 2

Protein Summary

Description

Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity).

Uniprot Accession IDs

• Q8N7G0
• Q15169
• Q6MZL7
• Q8N748

Gene Name

• POU5F2

Ensembl ID

• ENST00000606183
• ENSP00000489796
• ENSG00000248483

Symbol

• SPRM1
• SPRM-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
tissue sample	0.59
cell line	0.49
cell type or tissue	0.49
biological process	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.87   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0