Property Summary

NCBI Gene PubMed Count 21
PubMed Score 180.09
PubTator Score 135.92

Knowledge Summary


No data available


  Differential Expression (6)

Disease log2 FC p
cutaneous lupus erythematosus -1.400 8.0e-03
psoriasis -2.600 1.3e-04
group 4 medulloblastoma -1.200 1.6e-04
medulloblastoma, large-cell 1.200 1.6e-03
posterior fossa group A ependymoma -1.100 1.2e-08
ovarian cancer 1.300 2.9e-08

Gene RIF (4)

24671357 Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer
21448695 CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma.
17959798 Strict control of Pou3f1 transgene expression is critical to proper myelination, and factors responsible for Pouf31 downregulation during myelination may play important roles in the development of peripheral neuropathies.
17195013 Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes.

AA Sequence

GGGASPPSAPPPPPPAALHHHHHHTLPGSVQ                                           421 - 451

Text Mined References (22)

PMID Year Title
24671357 2014 Expression of organic anion-transporting polypeptide 1A2 and organic cation transporter 6 as a predictor of pathologic response to neoadjuvant chemotherapy in triple negative breast cancer.
23192594 2013 Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
22589738 2012 Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
21448695 2011 Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma.
20453842 2010 Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
17959798 2007 Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.
17195013 2007 Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
12557005 2003 Oct6, a transcription factor controlling myelination, is a marker for active nerve regeneration in peripheral neuropathies.
9742157 1998 Promyelinating Schwann cells express Tst-1/SCIP/Oct-6.
9457692 1998 Human class III POU genes, POU3F1 and POU3F3, map to chromosomes 1p34.1 and 3p14.2.
9242494 1997 Functions of the POU domain genes Skn-1a/i and Tst-1/Oct-6/SCIP in epidermal differentiation.
9105675 1997 The class III POU factor Brn-4 interacts with other class III POU factors and the heterogeneous nuclear ribonucleoprotein U.
8663425 1996 Identification of the nuclear localization signal of the POU domain protein Tst-1/Oct6.
8662541 1996 The POU factor Oct-6 and Schwann cell differentiation.
8567814 1995 Expression of transcription regulating genes in human preimplantation embryos.
8451175 1993 The human Oct-6 POU transcription factor lacks the first 50 amino acids of its murine counterpart.
7909356 1994 Oct-6: a regulator of keratinocyte gene expression in stratified squamous epithelia.
7791781 1995 Functional interaction between the POU domain protein Tst-1/Oct-6 and the high-mobility-group protein HMG-I/Y.
7720710 1995 High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors.
1976514 1990 Oct-6: a POU transcription factor expressed in embryonal stem cells and in the developing brain.
1975954 1990 Expression and activity of the POU transcription factor SCIP.