1. Home
  2. Targets
  3. nucleic acid binding
  4. DNA binding protein
  5. DNA-directed DNA polymerase
  6. DNA-directed DNA/RNA polymerase mu

Tbio DNA-directed DNA/RNA polymerase mu

Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.

 Comments

Property Summary

NCBI Gene PubMed Count 31
PubMed Score 201.91
PubTator Score 65.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Cancer 2499 3.298 1.6
Xeroderma pigmentosum 43 3.145 1.6

Expression

Synonym

Accession Q9NP87 D3DVK4 Q6P5X8 Q86WQ9 Pol Mu
Symbols Tdt-N
Pol Mu

Gene

POLM

PANTHER Protein Class (3)

PDB

2DUN   2HTF   4LZD   4LZG   4M04   4M0A   4YCX   4YD1   4YD2   5TWP   5TWQ   5TWR   5TWS   5TXX   5TXZ   5TYB   5TYC   5TYD   5TYE   5TYF   5TYG   5TYU   5TYV   5TYW   5TYX   5TYY   5TYZ   5VZ7   5VZ8   5VZ9   5VZA   5VZB   5VZC   5VZD   5VZE   5VZF   5VZG   5VZH   5VZI  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (15)

See all...

 GO Function (3)

 GO Component (1)

 GO Process (4)

 Compartment GO Term (25)

See all...

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

See all...

Pathway (5)

Protein-protein Interaction (2)

ACAD8   CTU2  

Gene RIF (25)

AA Sequence 

MLPKRRRARVGSPSGDAASSTPPSTRFPGVAIYLVEPRMGRSRRAFLTGLARSKGFRVLDACSSEATHVV      1 - 70
MEETSAEEAVSWQERRMAAAPPGCTPPALLDISWLTESLGAGQPVPVECRHRLEVAGPRKGPLSPAWMPA     71 - 140
YACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLKALPSPVTTLSQLQGLPHFGEHSS    141 - 210
RVVQELLEHGVCEEVERVRRSERYQTMKLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGL    211 - 280
QHHQDLSTPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGHDVDFLITHPKEGQEAGLLPRV    281 - 350
MCRLQDQGLILYHQHQHSCCESPTRLAQQSHMDAFERSFCIFRLPQPPGAAVGGSTRPCPSWKAVRVDLV    351 - 420
VAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQKTFFQAASEEDIFRHLGLEYLPPE    421 - 490
QRNA                                                                      491 - 494
//

Text Mined References (41)

PMID Year Title