Property Summary

NCBI Gene PubMed Count 12
PubMed Score 103.23
PubTator Score 77.37

Knowledge Summary


No data available


  Differential Expression (7)

Disease log2 FC p
malignant mesothelioma -1.100 6.0e-06
pancreatic ductal adenocarcinoma liver m... -1.060 7.2e-03
intraductal papillary-mucinous neoplasm ... -1.800 6.4e-05
lung cancer -1.600 3.3e-05
inflammatory breast cancer -1.400 1.2e-04
Bipolar Disorder 1.281 3.6e-02
ovarian cancer -1.500 4.0e-07

Gene RIF (5)

19334528 RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene.
18703122 Three human PNRC splicing variants designated PNRC1c, PNRC1d and PNRC1f, are identified.
18281297 Functional analysis of the 5' flanking region of the human PNRC gene by deletion mutagenesis, transient transfection and luciferase assays revealed that the -123/+27 region is the minimal promoter of the human PNRC gene.
18187620 Knockdown of proline-rich nuclear receptor coactivator 1 (PNRC1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells
15122321 PNRC and Grb2, by interacting with each other, can suppress nuclear receptor-mediated regulation and growth factor-mediated regulation in human breast tissue

AA Sequence


Text Mined References (13)

PMID Year Title
19334528 [Transcriptional regulation of the human gene coding for proline-rich nuclear receptor coactivator (pnrc) by regulatory factor x (rfx1)].
18703122 2008 Identification and characterization of PNRC splicing variants.
18281297 2008 Transcriptional regulation of the human PNRC promoter by NFY in HepG2 cells.
17612402 2007 PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15122321 2004 A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11574675 2001 PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.
10894149 2000 PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1).
10428808 1999 Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells.
7578250 1995 Cloning a cDNA from human NK/T cells which codes for a protein with high proline content.