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Tchem
PNMT
Phenylethanolamine N-methyltransferase

Protein Summary
Description
Converts noradrenaline to adrenaline. The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269582
  • ENSP00000269582
  • ENSG00000141744

Symbol
  • PENT
  • PENT
  • PNMTase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.76
virus perturbation
0.76
drug
0.7
cell type or tissue
0.69
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.29   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 651.29   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0