| Tbio | Pancreatic lipase-related protein 2 |
Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis.
This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
This gene encodes a lipase that hydrolyzes galactolipids, the main components of plant membrane lipids. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the non-coding allele. [provided by RefSeq, Aug 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-10 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.1e-10 |
| psoriasis | 6694 | 3.3e-10 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.9e-07 |
| pancreatic cancer | 2398 | 1.1e-02 |
| gastric carcinoma | 807 | 3.5e-02 |
| ulcerative colitis | 1819 | 4.1e-02 |
| active Crohn's disease | 922 | 4.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active Crohn's disease | -1.579 | 4.6e-02 |
| gastric carcinoma | -2.600 | 3.5e-02 |
| intraductal papillary-mucinous adenoma (... | -9.700 | 1.1e-10 |
| intraductal papillary-mucinous carcinoma... | -9.600 | 1.1e-10 |
| intraductal papillary-mucinous neoplasm ... | -9.600 | 1.9e-07 |
| pancreatic cancer | -3.700 | 1.1e-02 |
| psoriasis | -2.300 | 3.3e-10 |
| ulcerative colitis | -1.600 | 4.1e-02 |
MLPPWTLGLLLLATVRGKEVCYGQLGCFSDEKPWAGTLQRPVKLLPWSPEDIDTRFLLYTNENPNNFQLI 1 - 70 TGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVEKVNCICVDWRHGSRAMYTQAVQNI 71 - 140 RVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAEAGRRLGGRVGRITGLDPAGPCFQDEPEEVRL 141 - 210 DPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHLDFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSC 211 - 280 NHLRSFEYYSSSVLNPDGFLGYPCASYDEFQESKCFPCPAEGCPKMGHYADQFKGKTSAVEQTFFLNTGE 281 - 350 SGNFTSWRYKVSVTLSGKEKVNGYIRIALYGSNENSKQYEIFKGSLKPDASHTCAIDVDFNVGKIQKVKF 351 - 420 LWNKRGINLSEPKLGASQITVQSGEDGTEYNFCSSDTVEENVLQSLYPC 421 - 469 //
