Tbio PMP2 Myelin P2 protein

Protein Summary

Description

May play a role in lipid transport protein in Schwann cells. May bind cholesterol. The protein encoded by this gene localizes to myelin sheaths of the peripheral nervous system. The encoded protein can bind both the membrane layers of the sheaths and monomeric lipids, and is thought to provide stability to the sheath. A defect in this gene was shown to be a cause of dominant demyelinating CMT neuropathy. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• P02689
• Q6FHL4

Gene Name

• PMP2

Ensembl ID

• ENST00000256103
• ENSP00000256103
• ENSG00000147588

Symbol

• P2
• MP2
• CMT1G
• FABP8
• M-FABP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
gene perturbation	0.63
cell line	0.61
molecular function	0.6
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.38   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 360.38   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0