1. Home
  2. Targets
  3. Polyamine-modulated factor 1

Tbio Polyamine-modulated factor 1

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.

 Comments

Property Summary

NCBI Gene PubMed Count 18
PubMed Score 4.93
PubTator Score 15.20

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
medulloblastoma, large-cell 6241 8.5e-06
ovarian cancer 8520 3.9e-05
group 3 medulloblastoma 4104 5.5e-04
Rheumatoid arthritis 1191 2.8e-03

Expression

  Differential Expression (4)

Disease log2 FC p
group 3 medulloblastoma 1.300 5.5e-04
medulloblastoma, large-cell 1.100 8.5e-06
ovarian cancer 1.100 3.9e-05
Rheumatoid arthritis -1.200 2.8e-03

Synonym

Accession Q6P1K2 A8K0C5 Q5TCJ8 Q5TCJ9 Q5TCK0 Q5TCK1 Q5TCK3 Q69YZ9 Q6PHR4 Q6ZVE6 Q86VJ6 Q8N4T6 Q9UBQ3 PMF-1
Symbols

Gene

PMF1

  Ortholog (5)

Species Source Disease
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA
Inparanoid OMA

 UniProt Keyword (17)

See all...

 GO Function (2)

 GO Component (7)

 GO Process (5)

 Compartment GO Term (38)

See all...

 GWAS Trait (2)

 HCA RNA Cell Line (56)

See all...

Pathway (16)

See all...

Protein-protein Interaction (24)

NRBF2   KNL1   ZC4H2   GCC2   RGPD8   BICD2   RUFY1   RUFY2   ZWINT   KIF21B   DSN1   SPC24   NDC80   CEP89   FBXO28   TSNAX   MIS12   NSL1   NUF2   ATG16L1   PPP1CC   SPC25   MLLT10   STXBP4  

PDB (2)

Gene RIF (4)

AA Sequence 

MAEASSANLGSGCEEKRHEGSSSESVPPGTTISRVKLLDTMVDTFLQKLVAAGSYQRFTDCYKCFYQLQP      1 - 70
AMTQQIYDKFIAQLQTSIREEISDIKEEGNLEAVLNALDKIVEEGKVRKEPAWRPSGIPEKDLHSVMAPY     71 - 140
FLQQRDTLRRHVQKQEAENQQLADAVLAGRRQVEELQLQVQAQQQAWQALHREQRELVAVLREPE         141 - 205
//

Text Mined References (19)

PMID Year Title