| Tbio | Polyamine-modulated factor 1 |
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
Comments
| Disease | Target Count |
|---|---|
| Cerebral Hemorrhage | 27 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6234 | 8.5e-06 |
| ovarian cancer | 8491 | 3.9e-05 |
| group 3 medulloblastoma | 2254 | 5.5e-04 |
| Rheumatoid Arthritis | 1170 | 2.8e-03 |
| Disease | log2 FC | p |
|---|---|---|
| Rheumatoid Arthritis | -1.200 | 2.8e-03 |
| medulloblastoma, large-cell | 1.100 | 8.5e-06 |
| group 3 medulloblastoma | 1.300 | 5.5e-04 |
| ovarian cancer | 1.100 | 3.9e-05 |
| PMID | Text | |
|---|---|---|
| 22682992 | Bladder carcinoma with unmethylated PMF1 was more likely to recur after BCG treatment. | |
| 19088041 | The association of PMF1 methylation with tumor progression and its diagnostic ability using urinary specimens support including PMF1 assessment for the clinical management of bladder cancer patients. | |
| 12020345 | Polyamine-modulated factor 1 binds to CSN7. |
| PMID | Year | Title | |
|---|---|---|---|
| 26496610 | 2015 | A human interactome in three quantitative dimensions organized by stoichiometries and abundances. | |
| 25416956 | 2014 | A proteome-scale map of the human interactome network. | |
| 24656865 | 2014 | Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage. | |
| 22682992 | 2013 | Polyamine-modulated factor-1 methylation predicts Bacillus Calmette-Guérin response in patients with high-grade non-muscle-invasive bladder carcinoma. | |
| 20360068 | 2010 | Systematic analysis of human protein complexes identifies chromosome segregation proteins. | |
| 19088041 | 2008 | Identification of PMF1 methylation in association with bladder cancer progression. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 17213182 | 2006 | Identification of genes related to Parkinson's disease using expressed sequence tags. | |
| 16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. | |
| 16585270 | 2006 | The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. | |
| 15502821 | 2004 | A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15371340 | 2004 | A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 12020345 | 2002 | Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression. | |
| 11256947 | 2001 | Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene. | |
| 10419538 | 1999 | Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. |
