Property Summary

NCBI Gene PubMed Count 130
PubMed Score 84.75
PubTator Score 61.62

Knowledge Summary


No data available


  Disease Sources (7)

Disease Target Count P-value
non-small cell lung cancer 2798 4.48210232508297E-8
posterior fossa group B ependymoma 1530 6.54620332733978E-7
acute quadriplegic myopathy 1157 2.2205325052571E-6
lung carcinoma 2844 1.15080309586905E-5
lung adenocarcinoma 2714 1.3505111249315E-5
colon cancer 1475 2.8939249581062E-5
psoriasis 6685 4.9649080176687E-5
limb girdle muscular dystrophy 2A 156 6.18960093930852E-5
adrenocortical carcinoma 1427 7.94168160248644E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 2.37754607031872E-4
interstitial cystitis 2299 4.64069247472804E-4
Atopic dermatitis 944 5.59872241385526E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00248449978496563
hereditary spastic paraplegia 313 0.00586108619642224
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0155765447266967
Becker muscular dystrophy 187 0.0203870957192959
adrenocortical adenoma 134 0.027204564493516
fibroadenoma 557 0.0316344349947688
Breast cancer 3099 0.0431780673280735
Disease Target Count Z-score Confidence
Dilated cardiomyopathy 51 0.0 5.0
Hypertrophic Cardiomyopathy 56 0.0 5.0
Disease Target Count Z-score Confidence
Cardiomyopathy 110 0.0 4.0
Disease Target Count Z-score Confidence
Centronuclear myopathy 21 3.261 1.6



Accession P26678 PLB
Symbols PLB




1K9N   1KCH   1PLN   1PLP   1PSL   1ZLL   2HYN  

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid

Gene RIF (73)

26966065 These data suggest that PLN is, at least partially, oligo-ubiquitinated at Lys(3) and degraded through Ser(16)-phosphorylation-mediated poly-ubiquitination during heart failure.
26743715 Phospholamban and sarcolipin are membrane proteins that differentially regulate SERCA function. (Review)
26542032 PLN may be a key molecular player in rigid substrate-induced cellular hypertrophy in eosinophilic esophagitis.
25983321 Although SLN and PLB binding to SERCA have different functional outcomes on the coupling efficiency of SERCA, both proteins decrease the apparent Ca(2+) affinity of the pump, suggesting that SLN and PLB inhibit SERCA by using a similar mechanism.
25928149 PLN mutations rarely cause cardiomyopathy
25775607 analysis of how the conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation
25563649 hereditary mutants of phospholamban are associated with heart failure [review]
25562800 PLN pentamers reduce phosphorylation of monomers at baseline and delay monomer phosphorylation upon PKA stimulation leading to increased interaction of PLN monomers with SERCA2a.
25504561 Engineered upregulation of PLB expression in hESC/iPSC-vCMs restores a positive inotropic response to beta-adrenergic stimulation.
25451386 Phospholamban, and its interacting partners, regulates excitation contraction coupling and myocardial contraction. [Review]

AA Sequence


Text Mined References (133)

PMID Year Title
26970417 2016 Phospholamban p.Arg14del cardiomyopathy is characterized by phospholamban aggregates, aggresomes, and autophagic degradation.
26966065 2016 Phospholamban degradation is induced by phosphorylation-mediated ubiquitination and inhibited by interaction with cardiac type Sarco(endo)plasmic reticulum Ca(2+)-ATPase.
26917049 2016 Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies.
26885692 2016 Cervical cancer systemic inflammation score: a novel predictor of prognosis.
26816378 2016 A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.
26800703 2016 Sudden Cardiac Arrest and Rare Genetic Variants in the Community.
26791827 2016 Intensive training and reduced volume increases muscle FXYD1 expression and phosphorylation at rest and during exercise in athletes.
26743715 2016 Phospholamban and sarcolipin: Are they functionally redundant or distinct regulators of the Sarco(Endo)Plasmic Reticulum Calcium ATPase?
26673394 2016 Phospholamban spontaneously reconstitutes into giant unilamellar vesicles where it generates a cation selective channel.
26643481 2016 Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta.