Protein Summary
May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin cytoskeleton to induce cell spreading. In conjunction with complement component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]
- ENST00000216446
- ENSP00000216446
- ENSG00000100558
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.94 | ||
gene perturbation | 0.92 | ||
cell type or tissue | 0.76 | ||
transcription factor perturbation | 0.74 | ||
histone modification site profile | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.08 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 69 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 19.08 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 69 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0