Tbio PLCD4 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Protein Summary

Description

Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. This gene encodes a member of the delta class of phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for cancer. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9BRC7
• Q53FS8
• hPLCD4

Gene Name

• PLCD4

Ensembl ID

• ENST00000417849
• ENSP00000396942
• ENSG00000115556
• ENST00000450993
• ENSP00000388631

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
metabolite	0.89
cellular component	0.68
tissue sample	0.66
pathway	0.65

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-4

Protein / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-4

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-4

Protein / Calcium-binding Protein / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-4

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Delta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.89   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0