Tbio PLAGL1 Zinc finger protein PLAGL1

Protein Summary

Description

Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide. This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q9UM63
• B2RBA4
• B2RCM8
• E1P595
• E1P597
• O76019
• Q7Z3V8
• Q92981
• Q96JR9
• Q9UIZ0

Gene Name

• PLAGL1

Ensembl ID

• ENST00000354765
• ENSP00000346810
• ENSG00000118495
• ENST00000360537
• ENSP00000353734
• ENST00000367571
• ENSP00000356543
• ENST00000367572
• ENSP00000356544
• ENST00000416623
• ENSP00000400060
• ENST00000417959
• ENSP00000395960
• ENST00000437412
• ENSP00000392418
• ENST00000444202
• ENSP00000400929
• ENST00000625622
• ENSP00000486355
• ENST00000647880
• ENSP00000496815
• ENST00000649211
• ENSP00000497492
• ENST00000649307
• ENSP00000496979
• ENST00000650125
• ENSP00000497363

Symbol

• LOT1
• ZAC
• ZAC
• LOT1
• ZAC1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.98
virus perturbation	0.92
gene perturbation	0.79
histone modification site profile	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.35   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 203   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.35   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0