| Tdark | Group XIIB secretory phospholipase A2-like protein |
Not known; does not seem to have catalytic activity.
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
The protein encoded by this gene belongs to the phospholipase A2 (PLA2) group of enzymes, which function in glycolipid hydrolysis with the release of free fatty acids and lysophospholipids. This family member has altered phospholipid-binding properties and is catalytically inactive. The protein is secreted, and together with microsomal triglyceride transfer protein, it functions to regulate HNF4alpha-induced hepatitis C virus infectivity. The expression of this gene is down-regulated in various tumors, suggesting that it may function as a negative regulator of tumor progression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ulcerative colitis | 1819 | 3.6e-06 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 5.4e-04 |
| medulloblastoma, large-cell | 6241 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| medulloblastoma, large-cell | 1.300 | 2.7e-02 |
| pancreatic ductal adenocarcinoma liver m... | -2.228 | 5.4e-04 |
| ulcerative colitis | -1.400 | 3.6e-06 |
