Tbio PLA1A Phospholipase A1 member A

Protein Summary

Description

Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q53H76
• B2R8V2
• B4DXA2
• O95991
• Q86WX6
• Q9UPD2

Gene Name

• PLA1A

Ensembl ID

• ENST00000273371
• ENSP00000273371
• ENSG00000144837
• ENST00000488919
• ENSP00000420625
• ENST00000495992
• ENSP00000417326

Symbol

• NMD
• PSPLA1
• PSPLA1
• PS-PLA1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
metabolite	0.61
tissue sample	0.61
PubMedID	0.6
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Storage Protein / Phospholipase A1 Member A

Protein / Hydrolase / Lipase / Phospholipase A1 Member A

Protein / Hydrolase / Esterase / Phospholipase A1 Member A

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase A1 Member A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.84   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.84   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0