| Tbio | Phospholipase A1 member A |
Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Isoform 2 hydrolyzes lyso-PS but not PS. Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production.
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 2.7e-15 |
| juvenile dermatomyositis | 1187 | 2.0e-10 |
| acute quadriplegic myopathy | 1158 | 4.4e-06 |
| invasive ductal carcinoma | 2951 | 4.8e-06 |
| ulcerative colitis | 1819 | 2.8e-05 |
| lung carcinoma | 2843 | 6.0e-05 |
| cutaneous lupus erythematosus | 1057 | 7.1e-05 |
| primary Sjogren syndrome | 735 | 8.0e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 9.6e-04 |
| lung cancer | 4740 | 1.7e-03 |
| interstitial cystitis | 2312 | 2.2e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 2.6e-03 |
| group 3 medulloblastoma | 4104 | 5.1e-03 |
| osteosarcoma | 7950 | 7.8e-03 |
| primitive neuroectodermal tumor | 3035 | 1.4e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Spinal muscular atrophy | 34 | 4.528 | 2.3 |
| Muscular atrophy | 71 | 3.908 | 2.0 |
| Pelizaeus-Merzbacher disease | 19 | 3.299 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.198 | 4.4e-06 |
| autosomal dominant Emery-Dreifuss muscul... | 1.112 | 2.6e-03 |
| cutaneous lupus erythematosus | 4.200 | 7.1e-05 |
| group 3 medulloblastoma | -1.200 | 5.1e-03 |
| interstitial cystitis | 2.700 | 2.2e-03 |
| intraductal papillary-mucinous carcinoma... | -1.200 | 9.6e-04 |
| invasive ductal carcinoma | 1.105 | 4.8e-06 |
| juvenile dermatomyositis | 1.071 | 2.0e-10 |
| lung cancer | -2.100 | 1.7e-03 |
| lung carcinoma | -1.100 | 6.0e-05 |
| non-small cell lung cancer | -1.993 | 2.7e-15 |
| osteosarcoma | -1.273 | 7.8e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.668 | 2.5e-02 |
| primary Sjogren syndrome | 1.400 | 8.0e-04 |
| primitive neuroectodermal tumor | -1.100 | 1.4e-02 |
| ulcerative colitis | 1.600 | 2.8e-05 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG |
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQLVEGS 1 - 70 SDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLS 71 - 140 LEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDA 141 - 210 LFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAF 211 - 280 PCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKEL 281 - 350 RNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFC 351 - 420 TALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV 421 - 456 //
