Property Summary

NCBI Gene PubMed Count 19
PubMed Score 16.70
PubTator Score 14.13

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Gene RIF (6)

PMID Text
22648509 We identified four new loci (PKNOX2, MYH13, PHF2, and GPC6) associated with formal thought disorder in schizophrenia.
21298047 Using data from several genomewide case-control studies, we identified a strong and significant association signal with a novel gene, PKNOX2, on chromosome 11 with the composite phenotype in European-origin women
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
11549286 This novel PKNOX-related protein may interact with PBX proteins and play a role in tissue-specific regulation of transcription.

AA Sequence

MMQHASPAPALTMMATQNVPPPPYQDSPQMTATAQPPSKAQAVHISAPSAAASTPVPSAPIDPQAQLEAD      1 - 70
KRAVYRHPLFPLLTLLFEKCEQATQGSECITSASFDVDIENFVHQQEQEHKPFFSDDPELDNLMVKAIQV     71 - 140
LRIHLLELEKVNELCKDFCNRYITCLKTKMHSDNLLRNDLGGPYSPNQPSINLHSQDLLQNSPNSMSGVS    141 - 210
NNPQGIVVPASALQQGNIAMTTVNSQVVSGGALYQPVTMVTSQGQVVTQAIPQGAIQIQNTQVNLDLTSL    211 - 280
LDNEDKKSKNKRGVLPKHATNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPM    281 - 350
LDASNPDPAPKAKKIKSQHRPTQRFWPNSIAAGVLQQQGGAPGTNPDGSINLDNLQSLSSDSATMAMQQA    351 - 420
MMAAHDDSLDGTEEEDEDEMEEEEEEELEEEVDELQTTNVSDLGLEHSDSLE                      421 - 472
//

Text Mined References (21)

PMID Year Title
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
22688191 2012 Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.
22648509 2012 PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.
22488850 2012 Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
22137330 2012 Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.
21956439 2012 Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
21703634 2011 A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
21298047 2011 The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15339927 2004 Subcellular localization of multiple PREP2 isoforms is regulated by actin, tubulin, and nuclear export.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12412021 2002 Prep2: cloning and expression of a new prep family member.
11972344 2002 Characterization of PREP2, a paralog of PREP1, which defines a novel sub-family of the MEINOX TALE homeodomain transcription factors.
11549286 2001 Identification and characterization of human PKNOX2, a novel homeobox-containing gene.