PKIA
cAMP-dependent protein kinase inhibitor alpha
Protein Summary
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
- ENST00000352966
- ENSP00000336552
- ENSG00000171033
- ENST00000396418
- ENSP00000379696
- ENST00000518467
- ENSP00000430887
- PRKACN1
- PRKACN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 0.95 | ||
PubMedID | 0.87 | ||
transcription factor perturbation | 0.8 | ||
gene perturbation | 0.79 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.41 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 51 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.41 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 51 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0