Tbio PJA2 E3 ubiquitin-protein ligase Praja-2

Protein Summary

Description

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450).

Uniprot Accession IDs

• O43164
• A8K6U4
• D3DSZ5
• Q68D49
• Q8N1G5
• Praja2

Gene Name

• PJA2

Ensembl ID

• ENST00000361189
• ENSP00000354775
• ENSG00000198961
• ENST00000361557
• ENSP00000355284

Symbol

• KIAA0438
• RNF131
• RNF131
• Neurodap1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
transcription factor binding site profile	0.83
histone modification site profile	0.77
transcription factor perturbation	0.74
microRNA	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.11   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0