Property Summary

NCBI Gene PubMed Count 16
PubMed Score 7.04
PubTator Score 6.13

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (9)

Disease log2 FC p
ependymoma -1.300 4.6e-02
psoriasis 1.900 8.9e-05
osteosarcoma 2.322 1.1e-06
medulloblastoma, large-cell -1.100 7.2e-03
active Crohn's disease 1.321 6.5e-03
ulcerative colitis 1.200 3.8e-06
subependymal giant cell astrocytoma -1.745 3.3e-02
invasive ductal carcinoma -1.200 2.9e-03
ovarian cancer -1.100 2.3e-03

 MGI Phenotype (1)

Protein-protein Interaction (8)

Gene RIF (4)

PMID Text
21513699 these results suggest a role for PRAJA1 in regulating the level of PRC2 by targeting its free subunits for Ub-mediated proteasomal degradation.
21461837 Data provide clues into novel aspects of Praja1 function.
12036302 Involved in protein ubiquitination in the brain. Candidate gene for X-linked mental retardation.
11959851 A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.

AA Sequence

MGQESSKPVWPNPTGGYQSNTGRRYGRRHAYVSFRPPTSQRERIASQRKTNSEVPMHRSAPSQTTKRSRS      1 - 70
PFSTTRRSWDDSESSGTNLNIDNEDYSRYPPREYRASGSRRGMAYGHIDSYGADDSEEEGAGPVERPPVR     71 - 140
GKTGKFKDDKLYDPEKGARSLAGPPPHFSSFSRDVREERDKLDPVPAARCSASRADFLPQSSVASQSSSE    141 - 210
GKLATKGDSSERERREQNLPARPSRAPVSICGGGENTSKSAEEPVVRPKIRNLASPNCVKPKIFFDTDDD    211 - 280
DDMPHSTSRWRDTANDNEGHSDGLARRGRGESSSGYPEPKYPEDKREARSDQVKPEKVPRRRRTMADPDF    281 - 350
WTHSDDYYKYCDEDSDSDKEWIAALRRKYRSREQTLSSSGESWETLPGKEEREPPQAKVSASTGTSPGPG    351 - 420
ASASAGAGAGASAGSNGSNYLEEVREPSLQEEQASLEEGEIPWLQYHENDSSSEGDNDSGHELMQPGVFM    421 - 490
LDGNNNLEDDSSVSEDLEVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAV    491 - 560
DVEVANPPASKESIDALPEILVTEDHGAVGQEMCCPICCSEYVKGEVATELPCHHYFHKPCVSIWLQKSG    561 - 630
TCPVCRCMFPPPL                                                             631 - 643
//

Text Mined References (19)

PMID Year Title
25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21513699 2011 PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins.
21461837 2011 Protein microarrays for the identification of praja1 e3 ubiquitin ligase substrates.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20864041 2010 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17941886 2007 Contiguous gene deletions involving EFNB1, OPHN1, PJA1 and EDA in patients with craniofrontonasal syndrome.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16247473 2006 RING finger-dependent ubiquitination by PRAJA is dependent on TGF-beta and potentially defines the functional status of the tumor suppressor ELF.
16096365 2005 The role of PRAJA and ELF in TGF-beta signaling and gastric cancer.
15772651 2005 The DNA sequence of the human X chromosome.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12036302 2002 PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain.
11959851 2002 A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
9393880 1997 Praja1, a novel gene encoding a RING-H2 motif in mouse development.