Tchem PIK3C2G Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma

Protein Summary

Description

Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis (By similarity). The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• O75747
• A1L3U0
• PI3K-C2-gamma

Gene Name

• PIK3C2G

Ensembl ID

• ENST00000266497
• ENSP00000266497
• ENSG00000139144
• ENST00000433979
• ENSP00000404845

Symbol

• PI3K-C2GAMMA
• PI3K-C2-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.96
gene perturbation	0.7
cell line	0.63
small molecule	0.62

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Phosphatidylinositol 4-phosphate 3-kinase C2 Domain-containing Subunit Gamma

DTO Classes

Protein / Kinase / Non-protein Kinase / Lipid Kinase / Pi3/pi4 Kinase Family / Phosphatidylinositol 4-phosphate 3-kinase C2 Domain-containing Subunit Gamma

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.08   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.08   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0