| Tdark | GPI mannosyltransferase 4 |
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues.
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. This gene encodes a protein that is localized to the endoplasmic reticulum, and is involved in GPI anchor biosynthesis. As shown for the yeast homolog, which is a member of a family of dolichol-phosphate-mannose (Dol-P-Man)-dependent mannosyltransferases, this protein can also add a side-branching fourth mannose to GPI precursors during the assembly of GPI anchors. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.9e-13 |
| ependymoma | 4679 | 1.0e-08 |
| pediatric high grade glioma | 1064 | 6.9e-07 |
| medulloblastoma | 720 | 1.1e-06 |
| glioblastoma | 5792 | 1.2e-06 |
| ulcerative colitis | 1819 | 6.9e-06 |
| pituitary cancer | 1972 | 1.7e-05 |
| breast carcinoma | 1638 | 1.9e-04 |
| medulloblastoma, large-cell | 6241 | 3.8e-04 |
| cutaneous lupus erythematosus | 1057 | 1.8e-03 |
| interstitial cystitis | 2312 | 2.0e-03 |
| colon cancer | 1478 | 5.1e-03 |
| primitive neuroectodermal tumor | 3035 | 1.2e-02 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| lung cancer | 4740 | 2.8e-02 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.2e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Intracranial aneurysm | 24 | 3.593 | 1.8 |
| Alpha 1-antitrypsin deficiency | 11 | 3.196 | 1.6 |
| Visceral leishmaniasis | 14 | 3.005 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| breast carcinoma | -1.200 | 1.9e-04 |
| colon cancer | -3.500 | 5.1e-03 |
| cutaneous lupus erythematosus | -1.200 | 1.8e-03 |
| ependymoma | -1.500 | 1.0e-08 |
| glioblastoma | -1.100 | 1.2e-06 |
| interstitial cystitis | -1.400 | 2.0e-03 |
| intraductal papillary-mucinous carcinoma... | 1.300 | 3.2e-02 |
| invasive ductal carcinoma | -1.100 | 1.2e-02 |
| lung cancer | 1.100 | 2.8e-02 |
| lung carcinoma | 1.100 | 2.9e-13 |
| medulloblastoma | -1.200 | 1.1e-06 |
| medulloblastoma, large-cell | -1.300 | 3.8e-04 |
| pediatric high grade glioma | -1.400 | 6.9e-07 |
| pituitary cancer | 1.300 | 1.7e-05 |
| primitive neuroectodermal tumor | -1.100 | 1.2e-02 |
| subependymal giant cell astrocytoma | -1.281 | 4.3e-02 |
| ulcerative colitis | -2.200 | 6.9e-06 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG | ||
| OMA EggNOG |
MQICGSSVASVAAGTSFQVLGPVCWQQLDLKMAVRVLWGGLSLLRVLWCLLPQTGYVHPDEFFQSPEVMA 1 - 70 EDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFAL 71 - 140 DGAVYHLAPPMGADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPR 141 - 210 WRSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGAALTAAVFVATDSWYF 211 - 280 SSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQRLQVGLQASAQ 281 - 350 MGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCSPQTQPVPWKGTVVLFN 351 - 420 ALGALLFGCLHQGGLVPGLEYLEQVVHAPVLPSTPTHYTLLFTHTYMPPRHLLHLPGLGAPVEVVDMGGT 421 - 490 EDWALCQTLKSFTRQPACQVAGGPWLCRLFVVTPGTTRRAVEKCSFPFKNETLLFPHLTLEDPPALSSLL 491 - 560 SGAWRDHLSLHIVELGEET 561 - 579 //
