PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P
Protein Summary
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
- ENST00000360525
- ENSP00000353719
- ENSG00000185808
- ENST00000399098
- ENSP00000382049
- ENST00000399102
- ENSP00000382053
- ENST00000399103
- ENSP00000382054
- ENST00000464265
- ENSP00000420037
- DCRC
- DSCR5
- DSCRC
- DCRC
- DSRC
- DSCR5
- PIG-P
- DCRC-S
- EIEE55
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.9 | ||
virus perturbation | 0.85 | ||
transcription factor binding site profile | 0.82 | ||
cell type or tissue | 0.78 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.53 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 114 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 109.53 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 114 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0