Property Summary

NCBI Gene PubMed Count 18
PubMed Score 143.46
PubTator Score 194.21

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
glioblastoma 1.200 1.9e-03
sonic hedgehog group medulloblastoma 1.900 2.5e-07
atypical teratoid / rhabdoid tumor 1.400 8.4e-06
medulloblastoma, large-cell 1.800 5.1e-04
primitive neuroectodermal tumor 1.700 2.0e-04
lung adenocarcinoma 1.700 8.2e-07
inflammatory breast cancer 1.600 3.8e-03
psoriasis 1.700 8.9e-50

Gene RIF (13)

PMID Text
25589786 Pif1 readily unfolds a parallel quadruplex DNA substrate in a multiturnover reaction and also generates some product under single cycle conditions
25359767 Authors characterised a functional role for human PIF1 in DNA replication that becomes important for cell growth under oncogenic stress.
23924759 A minimum of 10 oligonucleotide bases are required for PIF1 binding and the hydrolysis of ATP.
23657261 when expressed in yeast, human PIF1 suppressed both G-quadruplex-associated DNA damage and telomere lengthening
23596008 the yeast ortholog of Pif1 appears to move along DNA in single nucleotide or base pair steps, powered by hydrolysis of 1 molecule of ATP.
22347400 PIF1 variant L319P was identified in three breast cancer families
21616935 Findings suggest roles for PIF1 in S-phase entry and progression that are essential to protect human tumor cells from apoptosis.
20524933 Human Pif1 could have a role in processing G4 structures that arise in the single-stranded nucleic acid intermediates formed during DNA replication and gene expression.
19700773 hPif1 specifically recognizes and unwinds DNA structures resembling putative stalled replication forks.
18835853 Evidence that the PIF1 N-terminal (PINT) domain as crucial functions in PIF1 helicase.
17827721 hPif1 in the nucleus may be involved in chromosome maintenance in association with DNA replication
17172855 Human PIF, like S. cerevisiae Pif1p, plays a role in telomerase regulation.
16522649 hPif1 may regulate telomere elongation by decreasing telomerase processivity, possibly via a mechanism that involves the unwinding of telomerase RNA from telomeric DNA by hPif1.

AA Sequence

MLSGIEAAAGEYEDSELRCRVAVEELSPGGQPRRRQALRTAELSLGRNERRELMLRLQAPGPAGRPRCFP      1 - 70
LRAARLFTRFAEAGRSTLRLPAHDTPGAGAVQLLLSDCPPDRLRRFLRTLRLKLAAAPGPGPASARAQLL     71 - 140
GPRPRDFVTISPVQPEERRLRAATRVPDTTLVKRPVEPQAGAEPSTEAPRWPLPVKRLSLPSTKPQLSEE    141 - 210
QAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAP    211 - 280
LAQCVALAQRPGVRQGWLNCQRLVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPV    281 - 350
TKGSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDEVTRQLQATASHKVGRDGI    351 - 420
VATRLCTHQDDVALTNERRLQELPGKVHRFEAMDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVS    421 - 490
RGLVNGARGVVVGFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAMSIHKSQGM    491 - 560
TLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVRCDPRVLHFYATLRRGRSLSLESPDDDEA    561 - 630
ASDQENMDPIL                                                               631 - 641
//

Text Mined References (23)

PMID Year Title
25589786 2015 A parallel quadruplex DNA is bound tightly but unfolded slowly by pif1 helicase.
25359767 2014 Human PIF1 helicase supports DNA replication and cell growth under oncogenic-stress.
23924759 Determination of the biochemical properties of full-length human PIF1 ATPase.
23657261 2013 Pif1 family helicases suppress genome instability at G-quadruplex motifs.
23596008 2013 Yeast Pif1 helicase exhibits a one-base-pair stepping mechanism for unwinding duplex DNA.
23275553 2013 Alternative translation initiation augments the human mitochondrial proteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22347400 2012 A genomewide screen for suppressors of Alu-mediated rearrangements reveals a role for PIF1.
21616935 2011 Suppression of apoptosis by PIF1 helicase in human tumor cells.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20524933 2010 Human Pif1 helicase is a G-quadruplex DNA-binding protein with G-quadruplex DNA-unwinding activity.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19700773 2009 Human Pif1 helicase unwinds synthetic DNA structures resembling stalled DNA replication forks.
18835853 2008 Biochemical analysis of human PIF1 helicase and functions of its N-terminal domain.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17827721 2007 Mitochondrial and nuclear localization of human Pif1 helicase.
17172855 2006 Human PIF helicase is cell cycle regulated and associates with telomerase.
16680374 2006 Characterization of ATPase activity of recombinant human Pif1.
16522649 2006 The human Pif1 helicase, a potential Escherichia coli RecD homologue, inhibits telomerase activity.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10926538 2000 Pif1p helicase, a catalytic inhibitor of telomerase in yeast.