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Tbio
PIEZO2
Piezo-type mechanosensitive ion channel component 2

Protein Summary
Description
Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302079
  • ENSP00000303316
  • ENSG00000154864
  • ENST00000503781
  • ENSP00000421377
  • ENST00000580640
  • ENSP00000463094

Symbol
  • C18orf30
  • C18orf58
  • FAM38B
  • DA3
  • DA5
  • MWKS
  • DAIPT
  • FAM38B
  • HsT748
  • HsT771
  • FAM38B2
  • C18orf30
  • C18orf58
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
phenotype
0.83
kinase perturbation
0.71
cell type or tissue
0.68
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.74   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.74   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0