Property Summary

NCBI Gene PubMed Count 16
PubMed Score 1.83
PubTator Score 9.68

Knowledge Summary


No data available



  Differential Expression (2)

Protein-protein Interaction (7)

Gene RIF (10)

26143926 Here two crystal structures are presented: the structure of human PIK42A and the structure of PIK42B containing a nucleoside analogue.
24972704 Results provide evidence that type II PtdIns 4-kinase b was indeed recruited to CD4- p56lck complex upon CD4 receptor cross linking, suggests a mechanism for its association and a role for it in CD4-mediated intracellular calcium release.
24481753 Canonical tyrosine residues mutation in FcepsilonRIgamma ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases.
23619705 type II PtdIns 4-kinase beta is a key component in early T cell activation signaling cascades
20583997 PIP4Kbeta interacts with and modulates nuclear localization of the PIP4Kalpha.
19539307 There is no evidence to suggest that PI4K2B is contributing to bipolar disorder in this family but a role for this gene in schizophrenia has not been excluded.
19539307 Observational study of gene-disease association. (HuGE Navigator)
18316730 LB-PI4K2B-1S-specific CD4(+) T cells contributed to the antitumor response by both directly eliminating malignant cells as effector cells and stimulating CD8(+) T cell immunity as helper cells.
16949365 UV irradiation increases nuclear PtdIns5P levels via inhibition of the activity of the beta isoform of PtdIns5P 4-kinase (PIP4Kbeta), an enzyme that can phosphorylate and remove PtdIns5P.
16337488 Type II PtdIns 4-kinase beta interacts with TCR-CD3 zeta chain. The C-terminal ITAM is critical for enzyme docking on the zeta chain. The association is tyrosyl phosphorylation dependent. Mutation of Y-151 & Y-142 disrupts interaction of the 2 proteins.

AA Sequence


Text Mined References (20)

PMID Year Title
26143926 2015 The high-resolution crystal structure of phosphatidylinositol 4-kinase II? and the crystal structure of phosphatidylinositol 4-kinase II? containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design.
24972704 2014 Type II PtdIns 4-kinase ? associates with CD4-p56lck complex and is involved in CD4 receptor signaling.
24481753 2014 Type II phosphatidylinositol 4-kinases interact with Fc?RI? subunit in RBL-2H3 cells.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23619705 2013 Type II phosphatidylinositol 4-kinase ? is an integral signaling component of early T cell activation mechanisms.
20583997 2010 PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha.
19946888 2010 Defining the membrane proteome of NK cells.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19539307 2009 A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B.
19369195 2009 Large-scale proteomics analysis of the human kinome.
18316730 2008 Identification of phosphatidylinositol 4-kinase type II beta as HLA class II-restricted target in graft versus leukemia reactivity.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16949365 2006 Nuclear PtdIns5P as a transducer of stress signaling: an in vivo role for PIP4Kbeta.
16337488 2006 Type II phosphatidylinositol 4-kinase beta associates with TCR-CD3 zeta chain in Jurkat cells.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12324459 2002 Type II phosphatidylinositol 4-kinase beta is a cytosolic and peripheral membrane protein that is recruited to the plasma membrane and activated by Rac-GTP.
11923287 2002 Characterization of type II phosphatidylinositol 4-kinase isoforms reveals association of the enzymes with endosomal vesicular compartments.
11907035 2002 Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor.