Tbio PHLDA1 Pleckstrin homology-like domain family A member 1

Protein Summary

Description

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation. This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WV24
• A1A4G9
• Q15184
• Q2TAN2
• Q9NZ17

Gene Name

• PHLDA1

Ensembl ID

• ENST00000266671
• ENSP00000266671
• ENSG00000139289
• ENST00000619060
• ENSP00000480767

Symbol

• PHRIP
• TDAG51
• PHRIP
• TDAG51
• DT1P1B11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.99
small molecule perturbation	0.99
gene perturbation	0.98
transcription factor binding site profile	0.96

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 212   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.49   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0