Property Summary

NCBI Gene PubMed Count 13
PubMed Score 96.18
PubTator Score 56.93

Knowledge Summary


No data available


  Disease (1)

Disease Target Count P-value
osteosarcoma 7933 1.1e-05


  Differential Expression (1)

Disease log2 FC p
osteosarcoma 2.042 1.1e-05

 MGI Phenotype (1)

Gene RIF (3)

26244496 We found PHF5A, a component of the U2 snRNP mRNA splicing factor, blocks expression from recombinant Adeno-associated virus vectors
23651857 PHF5A facilitates recognition of exons with unusual C-rich 3' splice sites in thousands of essential genes
12054543 The molecular and genetic research in this paper is performed on mouse but the paper identifies and discusses homologues found in human genomic sequence databases.

AA Sequence

YCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR                                   71 - 110

Text Mined References (18)

PMID Year Title
26244496 2015 An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
23651857 2013 Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22681889 2012 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
22658674 2012 Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
21269460 2011 Initial characterization of the human central proteome.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
18076038 2008 Complex assembly mechanism and an RNA-binding mode of the human p14-SF3b155 spliceosomal protein complex identified by NMR solution structure and functional analyses.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15461802 2004 A genome annotation-driven approach to cloning the human ORFeome.
15146077 2004 The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome.
12738865 2003 Molecular architecture of the multiprotein splicing factor SF3b.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12234937 2002 Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.
12226669 2002 Comprehensive proteomic analysis of the human spliceosome.
12054543 2002 Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif.
10591208 1999 The DNA sequence of human chromosome 22.