Tbio PHC3 Polyhomeotic-like protein 3

Protein Summary

Description

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Uniprot Accession IDs

• Q8NDX5
• A2RRP9
• Q5HYF0
• Q6NSG2
• Q8NFT7
• Q8NFZ1
• Q8TBM2
• Q9H971
• Q9H9I4

Gene Name

• PHC3

Ensembl ID

• ENST00000494943
• ENSP00000420271
• ENSG00000173889
• ENST00000495893
• ENSP00000420294
• ENST00000497658
• ENSP00000420454

Symbol

• EDR3
• PH3
• EDR3
• HPH3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.96
microRNA	0.74
drug perturbation	0.71
cellular component	0.67
cell line	0.62

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Polyhomeotic-like Protein 3

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Polyhomeotic-like Protein 3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Polyhomeotic-like Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 859.97   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 859.97   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0