Property Summary

NCBI Gene PubMed Count 16
PubMed Score 239.82
PubTator Score 52.45

Knowledge Summary


No data available



  Differential Expression (5)

Disease log2 FC p
psoriasis -1.600 3.5e-04
osteosarcoma -1.849 3.4e-05
glioblastoma 1.300 4.2e-05
pilocytic astrocytoma 1.200 9.0e-07
subependymal giant cell astrocytoma 2.056 9.6e-04


Accession Q9NXJ5 A8K1Q3 Q8IVT1
Symbols PGI


PANTHER Protein Class (3)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (7)

26078706 cytosolic peptidases(puromycin-sensitive aminopeptidase (PSA), aminopeptidase B (APB) and pyroglutamyl-peptidase I (PGI) ) may be involved in colorectal carcinogenesis
25687677 The specific reduction of the levels of pyroglutamyl-aminopeptidase activity in serum of liver cirrhosis patients might be considered as a potential candidate to be included in a combination of markers for the diagnosis of this disease.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19460752 Knockdown of pyroglutamyl-peptidase I (PGPEP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
15380924 The activities of pyroglutamyl peptidase I and prolyl endopeptidase in necrozoospermia were found to be higher in the corresponding soluble and particulate sperm fractions, respectively, with respect to those measured in normozoospermic semen
15014037 VX-710 modulates Pgp, MRP-1, and BCRP(R482), and has potential as a clinical broad-spectrum multidrug resistance modulator in malignancies.
12651114 cloning and sequencing of the human (AJ278828) pyroglutamyl-peptidase I

AA Sequence


Text Mined References (18)

PMID Year Title
26078706 2015 Altered Activity and Expression of Cytosolic Peptidases in Colorectal Cancer.
25687677 2015 Serum pyroglutamyl aminopeptidase activity: a promising novel biomarker candidate for liver cirrhosis.
24024966 2013 Genome-wide association study of chronic periodontitis in a general German population.
20889312 2010 A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15380924 2004 Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia.
15057824 2004 The DNA sequence and biology of human chromosome 19.
15014037 2004 VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12651114 2003 Pyroglutamyl-peptidase I: cloning, sequencing, and characterisation of the recombinant human enzyme.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12030812 Regional and subcellular distribution of soluble aminopeptidase in the human and the rat brain: a comparative study.
9920379 1998 Pyroglutamyl peptidase: an overview of the three known enzymatic forms.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
2575716 1989 Pyroglutamyl peptidase II inhibition specifically increases recovery of TRH released from rat brain slices.
2104543 1990 Degradation of thyrotropin-releasing hormone and luteinising hormone-releasing hormone by enzymes of brain tissue.