| Tbio | Glucose 1,6-bisphosphate synthase |
Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.8e-12 |
| lung adenocarcinoma | 2716 | 4.0e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.6e-08 |
| osteosarcoma | 7950 | 1.8e-07 |
| Astrocytoma, Pilocytic | 3081 | 8.6e-07 |
| glioblastoma | 5792 | 2.7e-05 |
| medulloblastoma, large-cell | 6241 | 3.6e-05 |
| ovarian cancer | 8520 | 1.7e-04 |
| pancreatic cancer | 2398 | 1.9e-04 |
| tuberculosis | 2010 | 2.0e-04 |
| pituitary cancer | 1972 | 5.3e-04 |
| ductal carcinoma in situ | 1745 | 1.1e-03 |
| adult high grade glioma | 3801 | 2.9e-03 |
| astrocytic glioma | 2597 | 3.5e-03 |
| oligodendroglioma | 2850 | 7.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.1e-03 |
| gastric cancer | 459 | 8.6e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.2e-02 |
| Pick disease | 1894 | 1.6e-02 |
| Rheumatoid arthritis | 1191 | 1.6e-02 |
| X-linked cerebral adrenoleukodystrophy | 116 | 2.3e-02 |
| ependymoma | 4679 | 2.5e-02 |
| active ulcerative colitis | 764 | 3.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.4e-02 |
| group 3 medulloblastoma | 4104 | 4.1e-02 |
| adrenocortical carcinoma | 1428 | 4.3e-02 |
MAENTEGDLNSNLLHAPYHTGDPQLDTAIGQWLRWDKNPKTKEQIENLLRNGMNKELRDRLCCRMTFGTA 1 - 70 GLRSAMGAGFCYINDLTVIQSTQGMYKYLERCFSDFKQRGFVVGYDTRGQVTSSCSSQRLAKLTAAVLLA 71 - 140 KDVPVYLFSRYVPTPFVPYAVQKLKAVAGVMITASHNRKEDNGYKVYWETGAQITSPHDKEILKCIEECV 141 - 210 EPWNGSWNDNLVDTSPLKRDPLQDICRRYMEDLKKICFYRELNSKTTLKFVHTSFHGVGHDYVQLAFKVF 211 - 280 GFKPPIPVPEQKDPDPDFSTVKCPNPEEGESVLELSLRLAEKENARVVLATDPDADRLAAAELQENGCWK 281 - 350 VFTGNELAALFGWWMFDCWKKNKSRNADVKNVYMLATTVSSKILKAIALKEGFHFEETLPGFKWIGSRII 351 - 420 DLLENGKEVLFAFEESIGFLCGTSVLDKDGVSAAVVVAEMASYLETMNITLKQQLVKVYEKYGYHISKTS 421 - 490 YFLCYEPPTIKSIFERLRNFDSPKEYPKFCGTFAILHVRDVTTGYDSSQPNKKSVLPVSKNSQMITFTFQ 491 - 560 NGCVATLRTSGTEPKIKYYAEMCASPDQSDTALLEEELKKLIDALIENFLQPSKNGLIWRSV 561 - 622 //
