Tbio PGLYRP2 N-acetylmuramoyl-L-alanine amidase

Protein Summary

Description

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96PD5
• A8K050
• A8K8C7
• B2RMZ2
• B7ZM33
• Q68CK1
• Q96N74
• Q9UC60

Gene Name

• PGLYRP2

Ensembl ID

• ENST00000292609
• ENSP00000292609
• ENSG00000161031
• ENST00000340880
• ENSP00000345968

Symbol

• PGLYRPL
• PGRPL
• tagL
• PGRPL
• PGRP-L
• PGLYRPL
• HMFT0141
• TAGL-like
• tagl-beta
• tagL-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.77
molecular function	0.76
phenotype	0.58
cell type or tissue	0.5
cell line	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.59   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.59   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0