Property Summary

NCBI Gene PubMed Count 26
PubMed Score 58.95
PubTator Score 14.87

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Expression

  Differential Expression (2)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -3.572 2.9e-03
psoriasis 2.700 6.4e-80

Gene RIF (10)

PMID Text
26039076 a significant induction of three PGLYRPs 2-4 in primary human corneal epithelial cells (HCECs) exposed to live or heat-killed Candida albicans, is reported.
24838182 This study demonistrated that PGLYRP2 single-nucleotide polymorphisms is risk of Parkinson's disease.
20237496 Observational study of gene-disease association. (HuGE Navigator)
19023099 Observational study of gene-disease association. (HuGE Navigator)
18649358 Observational study of gene-disease association. (HuGE Navigator)
17975119 Observational study of gene-disease association. (HuGE Navigator)
16714290 pglyrp2 expression in skin and liver is important for systemic and local innate immune responses to bacterial infections
16239516 PGLYRP2 may function in the skin and the eyes as an inducible scavenger of proinflammatory peptidoglycan.
16054449 Serum N-acetylmuramoyl-l-alanine amidaseand liver PGLYRP2 are the same protein encoded by the pglyrp2 gene.
12669421 Various types of human blood cells were tested for expression of the Tag7/PGRP-SA and TagL/PGRP-L proteins, which belong to the family of proteins possessing the lysozyme-like peptidoglycan recognition protein (PGRP) domain

AA Sequence

MAQGVLWILLGLLLWSDPGTASLPLLMDSVIQALAELEQKVPAAKTRHTASAWLMSAPNSGPHNRLYHFL      1 - 70
LGAWSLNATELDPCPLSPELLGLTKEVARHDVREGKEYGVVLAPDGSTVAVEPLLAGLEAGLQGRRVINL     71 - 140
PLDSMAAPWETGDTFPDVVAIAPDVRATSSPGLRDGSPDVTTADIGANTPDATKGCPDVQASLPDAKAKS    141 - 210
PPTMVDSLLAVTLAGNLGLTFLRGSQTQSHPDLGTEGCWDQLSAPRTFTLLDPKASLLTMAFLNGALDGV    211 - 280
ILGDYLSRTPEPRPSLSHLLSQYYGAGVARDPGFRSNFRRQNGAALTSASILAQQVWGTLVLLQRLEPVH    281 - 350
LQLQCMSQEQLAQVAANATKEFTEAFLGCPAIHPRCRWGAAPYRGRPKLLQLPLGFLYVHHTYVPAPPCT    351 - 420
DFTRCAANMRSMQRYHQDTQGWGDIGYSFVVGSDGYVYEGRGWHWVGAHTLGHNSRGFGVAIVGNYTAAL    421 - 490
PTEAALRTVRDTLPSCAVRAGLLRPDYALLGHRQLVRTDCPGDALFDLLRTWPHFTATVKPRPARSVSKR    491 - 560
SRREPPPRTLPATDLQ                                                          561 - 576
//

Text Mined References (28)

PMID Year Title
26039076 2015 A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins.
24838182 2014 Peptidoglycan recognition protein genes and risk of Parkinson's disease.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19159218 2009 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
19023099 2009 Gene variants associated with ischemic stroke: the cardiovascular health study.
18649358 2008 Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.
17975119 2008 Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.
16714290 2006 Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
16239516 2005 Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.
16054449 2005 Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15340161 2004 Signal peptide prediction based on analysis of experimentally verified cleavage sites.
15340057 2004 Innate immune responses in peptidoglycan recognition protein L-deficient mice.
15221005 2004 Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14506276 2003 Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.
12975309 2003 The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
12754519 2003 Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
12669421 2003 [Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells].
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11752456 2001 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.
11461926 2001 Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.
11441184 2001 Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.
7663175 1995 Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography.