Property Summary

NCBI Gene PubMed Count 86
PubMed Score 87.13
PubTator Score 87.43

Knowledge Summary


No data available


Gene RIF (2)

24284944 Pepsin and pepsinogen in middle ear effusion are probably caused by LPR and may be involved in the pathogenesis of OME.
23311720 Levels of pepsinogen/pepsin A and C are higher in the mouth swabs of preterm infants with gastroesophageal reflux.

AA Sequence

MNVPTESGELWILGDVFIRQYFTVFDRANNQVGLAPVA                                    351 - 388

Text Mined References (88)

PMID Year Title
25314140 2014 Prediction of gastric cancer development by serum pepsinogen test and Helicobacter pylori seropositivity in Eastern Asians: a systematic review and meta-analysis.
24383519 2014 The value of serum pepsinogen levels for the diagnosis of gastric diseases in Chinese Han people in midsouth China.
24284944 2014 Role of pepsin and pepsinogen: linking laryngopharyngeal reflux with otitis media with effusion in children.
24170207 2014 Serum pepsinogen reference intervals in apparently healthy Chinese population with latex enhanced turbidimetric immunoassay.
24125879 2014 A possible association of low pepsinogen I and pepsinogen I/II with low and high body weight in Japanese men.
24004680 2013 Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease.
23897256 2013 Gastric cancer detection using gastric juice pepsinogen and melanoma-associated gene RNA.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23521833 2013 Expression of serum miR-20a-5p, let-7a, and miR-320a and their correlations with pepsinogen in atrophic gastritis and gastric cancer: a case-control study.
23311720 2013 Detection of pepsin in mouth swab: correlation with clinical gastroesophageal reflux in preterm infants.
23047493 2013 Serum pepsinogen I/II ratio is correlated with albuminuria in patients with type 2 diabetes.
23034090 2013 Identification of a high risk gastric cancer group using serum pepsinogen after successful eradication of Helicobacter pylori.
22992016 2013 Exploratory findings of audiometry in adult patients with otitis media with high pepsinogen concentrations: a preliminary study.
22304859 2012 Pepsinogen I/II ratio is related to glucose, triacylglycerol, and uric acid levels.
22066020 2011 Accuracy and cut-off values of pepsinogens I, II and gastrin 17 for diagnosis of gastric fundic atrophy: influence of gastritis.
21989121 2012 Serum pepsinogen test for early detection of gastric cancer in a European country.
21970995 2011 Detection of pepsinogen in the neonatal lung and stomach by immunohistochemistry.
21547904 2012 Low serum pepsinogen I and pepsinogen I/II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer: 14-year follow up result in a rural Chinese community.
21455714 2011 The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk.
21407214 2011 Plasma pepsinogens, antibodies against Helicobacter pylori, and risk of gastric cancer in the Shanghai Women's Health Study Cohort.
20981206 2010 The role of serum pepsinogen in the detection of gastric cancer.
20428942 2010 Serum pepsinogens in gastric cancer screening.
19890696 2009 Validation of the pepsinogen test method for gastric cancer screening using a follow-up study.
19800305 2009 Serum pepsinogen level, atrophic gastritis and the risk of incident pancreatic cancer--a prospective cohort study.
17379991 2007 Serum pepsinogen and gastric cancer screening.
17136346 2007 Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression.
16554811 2006 Human chromosome 11 DNA sequence and analysis including novel gene identification.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12698190 2003 Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.
12588289 2003 Ratio between serum IL-8 and pepsinogen A/C: a marker for atrophic body gastritis.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11915945 2002 Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development.
10675278 2000 Pepsinogens: physiology, pharmacology pathophysiology and exercise.
9855083 1998 Serum antibodies to H+,K+-ATPase, serum pepsinogen A and Helicobacter pylori in relation to gastric mucosa morphology in patients with low or low-normal concentrations of serum cobalamins.
9797498 1998 Advantages of serum pepsinogen A combined with gastrin or pepsinogen C as first-line analytes in the evaluation of suspected cobalamin deficiency: a study in patients previously not subjected to gastrointestinal surgery.
9561228 1998 Crystal structure of human pepsinogen A.
9525001 1998 The relationship of Helicobacter pylori colonization, the serum pepsinogen A level, and gastric resection.
9421118 1997 Helicobacter pylori genotypes influence serum pepsinogen C levels.
9061458 1997 Fast detection of phosphorylation of human pepsinogen A, human pepsinogen C and swine pepsinogen using a combination of reversed-phase high-performance liquid chromatography and capillary zone electrophoresis for peptide mapping.
8751234 Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C.
8540382 1995 Transcription regulation of human and porcine pepsinogen A.
8504820 1993 Gastric chief cell-specific transcription of the pepsinogen A gene.
8322031 1993 Pepsinogen A and C serum levels in relation to acute NSAID-associated mucosal lesions in healthy volunteers.
8244094 1993 Diagnostic value of serum pepsinogen C in patients with raised serum concentrations of pepsinogen A.
8187358 1994 The renal handling of pepsinogen A isozymogens in man.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
8053437 1994 Helicobacter pylori infection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication.
8038355 1994 Effect of enprostil on serum gastrin and pepsinogen A and C levels in patients on long-term treatment with omeprazole.
7926498 1994 The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group.
7923573 1994 O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group.
7886402 1994 Evaluation of pepsinogen A and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions.
7663352 1995 Crystal structure of human pepsin and its complex with pepstatin.
6774973 1980 Isolation of an activation intermediate and determination of the amino acid sequence of the activation segment of human pepsinogen A.
6300126 1983 Primary structure of human pepsinogen gene.
4909888 1970 Carboxyl-terminal sequence of human gastricsin and pepsin.
4586732 1973 The pepsinogens of human gastric mucosa.
3839486 1985 Assignment of human pepsinogen A locus to the q12-pter region of chromosome 11.
3815274 1987 Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels.
3780036 1986 Pepsinogen A polymorphism in gastric mucosa and urine, with special reference to patients with gastric cancer.
3554488 1987 Enzyme-linked immunosorbent assay and radioimmunoassay of serum pepsinogen A.
3467902 1986 Assignment of the pepsinogen gene complex (PGA) to human chromosome region 11q13 by in situ hybridization.
3305135 1987 Gastric proteases in Barrett's esophagus.
3197840 1988 Activation of human pepsinogens.
3191614 1988 Differential expression of pepsinogen isozymogens in a patient with Barrett esophagus.
3115885 1987 Molecular cloning of a pair of human pepsinogen A genes which differ by a Glu----Lys mutation in the activation peptide.
3017318 1986 Close linkage of human chromosomal pepsinogen A genes.
2920466 1989 The renal metabolism of pepsinogen A and C in man.
2901984 1988 Identification of a Glu greater than Lys substitution in the activation segment of human pepsinogen A-3 and -5 isozymogens by peptide mapping using endoproteinase Lys-C.
2892778 1988 Genomic structure and evolution of the human pepsinogen A multigene family.
2831884 1988 Hypomethylation and expression of pepsinogen A genes in the fundic mucosa of human stomach.
2799289 1989 The ratio of pepsinogen A to pepsinogen C: a sensitive test for atrophic gastritis.
2797342 1989 Tubular handling of pepsinogen A and C in man: evidence for two distinct tubular reabsorption mechanisms for low molecular weight proteins in man.
2714789 1989 Nucleotide sequence comparison of five human pepsinogen A (PGA) genes: evolution of the PGA multigene family.
2609705 1989 Pepsinogens A and C: purification from human gastric mucosa and determination in serum by optimized radioimmunoassays.
2566575 1989 Family and population studies on the human pepsinogen A multigene family.
2515193 1989 A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.
2478370 1989 The glomerular sieving of pepsinogen A and C in man.
2415509 1985 Isolation of human, swine, and rat prepepsinogens and calf preprochymosin, and determination of the primary structures of their NH2-terminal signal sequences.
2229438 1990 Immunoblot technique to visualise serum pepsinogen A isozymogen patterns.
2227273 1990 Human pepsinogen A isozymogen patterns in serum and gastric mucosa.
2032552 1991 Localization of pepsinogen (A and C) and cellular differentiation of pepsinogen-synthesizing cells in the human gastric mucosa.
1968039 1990 Human pepsinogen A (PGA): an informative gene complex located at 11q13.
1956484 1991 The effect of acute and chronic protein loading on urinary pepsinogen A excretion.
1906854 1991 Methylation and expression of human pepsinogen genes in normal tissues and their alteration in stomach cancer.
1812762 1991 Analysis of the promoter of a human pepsinogen A gene.
1455184 1992 Gene structures of pepsinogens A and C.