| Tbio | Profilin-1 |
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 1.2e-09 |
| acute quadriplegic myopathy | 1158 | 1.4e-07 |
| glioblastoma | 5792 | 2.1e-07 |
| pediatric high grade glioma | 1064 | 2.8e-07 |
| ovarian cancer | 8520 | 1.0e-06 |
| lung adenocarcinoma | 2716 | 1.3e-06 |
| Astrocytoma, Pilocytic | 3081 | 4.5e-06 |
| Becker muscular dystrophy | 191 | 5.0e-05 |
| medulloblastoma, large-cell | 6241 | 2.4e-04 |
| primitive neuroectodermal tumor | 3035 | 2.6e-04 |
| psoriasis | 6694 | 3.3e-04 |
| medulloblastoma | 720 | 4.8e-04 |
| astrocytoma | 1146 | 1.3e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.7e-03 |
| Rheumatoid arthritis | 1191 | 1.9e-03 |
| Multiple myeloma | 1332 | 2.6e-03 |
| Waldenstrons macroglobulinemia | 765 | 5.4e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 5.5e-03 |
| pancreatic cancer | 2398 | 6.4e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Neurodegenerative disease | 414 | 0.0 | 4.0 |
| Disease | Target Count |
|---|---|
| Amyotrophic lateral sclerosis | 451 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.268 | 1.4e-07 |
| astrocytoma | 1.400 | 1.3e-03 |
| Astrocytoma, Pilocytic | 1.300 | 4.5e-06 |
| atypical teratoid / rhabdoid tumor | 2.100 | 1.2e-09 |
| Becker muscular dystrophy | 1.022 | 5.0e-05 |
| glioblastoma | 1.300 | 2.1e-07 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 1.7e-03 |
| lung adenocarcinoma | 1.373 | 1.3e-06 |
| medulloblastoma | 1.100 | 4.8e-04 |
| medulloblastoma, large-cell | 1.500 | 2.4e-04 |
| Multiple myeloma | 1.943 | 2.6e-03 |
| ovarian cancer | 2.900 | 1.0e-06 |
| pancreatic cancer | 1.200 | 6.4e-03 |
| pediatric high grade glioma | 1.700 | 2.8e-07 |
| primary pancreatic ductal adenocarcinoma | 1.148 | 5.5e-03 |
| primitive neuroectodermal tumor | 1.300 | 2.6e-04 |
| psoriasis | -1.500 | 3.3e-04 |
| Rheumatoid arthritis | -1.400 | 1.9e-03 |
| Waldenstrons macroglobulinemia | 1.314 | 5.4e-03 |
