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Tbio
PEX2
Peroxisome biogenesis factor 2

Protein Summary
Description
Somewhat implicated in the biogenesis of peroxisomes. This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357039
  • ENSP00000349543
  • ENSG00000164751
  • ENST00000520103
  • ENSP00000428590
  • ENST00000522527
  • ENSP00000428638

Symbol
  • PAF1
  • PMP3
  • PMP35
  • PXMP3
  • RNF72
  • PAF1
  • PMP3
  • ZWS3
  • PBD5A
  • PBD5B
  • PMP35
  • PXMP3
  • RNF72
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.86
transcription factor perturbation
0.8
cellular component
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.08   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.08   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0