| Tchem | Xaa-Pro dipeptidase |
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Hepatomegaly | 285 | 0.0 | 0.0 |
| Infection | 6 | 0.0 | 0.0 |
| Organophosphate poisoning | 4 | 0.0 | 0.0 |
| Prolidase deficiency | 1 | 0.0 | 0.0 |
| Respiratory Tract Diseases | 6 | 0.0 | 0.0 |
| Skin Ulcer | 48 | 0.0 | 0.0 |
| Splenomegaly | 190 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| tuberculosis | 2010 | 2.2e-08 |
| ovarian cancer | 8520 | 8.7e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 8.7e-04 |
| diabetes mellitus | 1728 | 1.5e-03 |
| astrocytoma | 1146 | 3.5e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 5.1e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 6.4e-03 |
| glioblastoma | 5792 | 3.1e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 2.7 |
| Type 2 diabetes mellitus | 272 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Sexual sadism | 1 | 4.183 | 2.1 |
| Intellectual disability | 1016 | 4.067 | 2.0 |
| Bacterial vaginosis | 15 | 3.419 | 1.7 |
| Connective tissue disease | 62 | 3.058 | 1.5 |
| Cancer | 2499 | 3.015 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.300 | 3.5e-03 |
| diabetes mellitus | -1.100 | 1.5e-03 |
| glioblastoma | 1.100 | 3.1e-02 |
| intraductal papillary-mucinous carcinoma... | -1.600 | 8.7e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.300 | 6.4e-03 |
| ovarian cancer | -1.100 | 8.7e-04 |
| pancreatic ductal adenocarcinoma liver m... | -2.162 | 5.1e-03 |
| tuberculosis | 1.500 | 2.2e-08 |
MAAATGPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQRYCTDTGVLFRQESF 1 - 70 FHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHATWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQK 71 - 140 PSVLLTLRGVNTDSGSVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEAHREVM 141 - 210 KAVKVGMKEYELESLFEHYCYSRGGMRHSSYTCICGSGENSAVLHYGHAGAPNDRTIQNGDMCLFDMGGE 211 - 280 YYCFASDITCSFPANGKFTADQKAVYEAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGS 281 - 350 VDAMVQAHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPGMVLTVEPGIYFIDH 351 - 420 LLDEALADPARASFLNREVLQRFRGFGGVRIEEDVVVTDSGIELLTCVPRTVEEIEACMAGCDKAFTPFS 421 - 490 GPK 491 - 493 //
