Property Summary

NCBI Gene PubMed Count 18
PubMed Score 2.50
PubTator Score 5.43

Knowledge Summary


No data available


  Differential Expression (19)

Disease log2 FC p
Rheumatoid Arthritis 1.100 3.9e-02
urothelial carcinoma -1.700 5.0e-03
malignant mesothelioma 3.300 6.7e-09
psoriasis -1.500 1.4e-09
cystic fibrosis -1.505 6.3e-05
atypical teratoid/rhabdoid tumor -1.400 3.8e-04
sonic hedgehog group medulloblastoma 1.400 8.6e-04
Atopic dermatitis -1.300 1.4e-03
adrenocortical carcinoma -1.288 1.6e-03
primary pancreatic ductal adenocarcinoma -1.453 2.1e-04
intraductal papillary-mucinous carcinoma... -2.000 1.4e-02
lung cancer -2.900 1.1e-05
breast carcinoma -1.600 1.7e-06
subependymal giant cell astrocytoma -1.473 4.6e-02
Breast cancer -3.000 1.8e-32
ductal carcinoma in situ -1.500 1.5e-03
invasive ductal carcinoma -1.900 1.2e-03
pituitary cancer -1.100 3.0e-02
pancreatic cancer -1.500 2.5e-04


Accession Q9HAT8 B2RDY5 Pellino-2



3EGA   3EGB  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Protein-protein Interaction (5)

Gene RIF (5)

25027698 A high-affinity Pellino2 e3 ubiquitin ligase binding domain is specific for phosphothreonine motifs.
22669975 Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
12860405 Pellino2 interacts with kinase-active as well as kinase-inactive IRAK1 and IRAK4
12804775 interacts with TRAF6 (tumor necrosis factor receptor associated factor 6) and TAK1 (transforming growth factor-beta activated kinase 1); can activate the mitogen activated protein kinase pathway

AA Sequence


Text Mined References (21)

PMID Year Title
25133637 2014 Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
25027698 2014 The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
23192594 2013 Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
23144326 2012 Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
22669975 2012 Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control.
21460395 2011 A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
19081057 2008 Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.
17997719 2008 The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.
17675297 2007 Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
16884718 2006 Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.
16713569 2006 A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15276183 2004 MD-2: the Toll 'gatekeeper' in endotoxin signalling.
15213237 2004 BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12860405 2003 Characterization of Pellino2, a substrate of IRAK1 and IRAK4.
12804775 2003 Pellino2 activates the mitogen activated protein kinase pathway.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12370331 2002 Cutting edge: mouse pellino-2 modulates IL-1 and lipopolysaccharide signaling.
11306823 2001 Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.