Tbio PEG3 Paternally-expressed gene 3 protein

Protein Summary

Description

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B (By similarity). Possesses a tumor suppressing activity in glioma cells. In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q9GZU2
• A7E2B8
• B4DIM4
• C9JP50
• P78418
• Q5H9P9
• Q7Z7H7
• Q8TF75
• Q9GZY2

Gene Name

• PEG3

Ensembl ID

• ENST00000326441
• ENSP00000326581
• ENSG00000198300
• ENST00000593695
• ENSP00000472402
• ENST00000598410
• ENSP00000473190
• ENST00000599534
• ENSP00000472395
• ENST00000599577
• ENSP00000469486
• ENST00000648694
• ENSP00000496914
• ENST00000649233
• ENSP00000498047
• ENST00000649428
• ENSP00000498138
• ENST00000649680
• ENSP00000497512
• ENST00000649876
• ENSP00000496867
• ENST00000650102
• ENSP00000497466
• ENST00000650632
• ENSP00000497971

Symbol

• KIAA0287
• ZSCAN24
• PW1
• ZNF904
• ZSCAN24
• ZKSCAN22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.92
transcription factor perturbation	0.88
protein domain	0.85
interacting protein	0.8
cell line	0.73

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / Paternally-expressed Gene 3 Protein

Protein / ... / Krab Box Transcription Factor / Paternally-expressed Gene 3 Protein

DTO Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / C2h2 Zinc Finger Transcription Factor / Krab Box Transcription Factor / Paternally-expressed Gene 3 Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.05   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 150   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.05   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0