| Tbio | Sister chromatid cohesion protein PDS5 homolog B |
Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells.
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 8.7e-20 |
| Breast cancer | 3578 | 1.3e-09 |
| malignant mesothelioma | 3232 | 1.3e-08 |
| ovarian cancer | 8520 | 1.4e-06 |
| glioblastoma | 5792 | 2.2e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.6e-05 |
| medulloblastoma, large-cell | 6241 | 3.2e-05 |
| Astrocytoma, Pilocytic | 3081 | 1.2e-04 |
| group 4 medulloblastoma | 1855 | 4.7e-04 |
| adult high grade glioma | 3801 | 5.5e-04 |
| pituitary cancer | 1972 | 6.3e-04 |
| invasive ductal carcinoma | 2951 | 8.4e-04 |
| primitive neuroectodermal tumor | 3035 | 2.2e-03 |
| psoriasis | 6694 | 3.5e-03 |
| osteosarcoma | 7950 | 3.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.1e-02 |
| astrocytic glioma | 2597 | 1.3e-02 |
| ependymoma | 4679 | 2.1e-02 |
| oligodendroglioma | 2850 | 2.3e-02 |
| subependymal giant cell astrocytoma | 2287 | 4.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 3.0 |
| Alzheimer's disease | 658 | 0.0 | 1.0 |
| Type 2 diabetes mellitus | 272 | 0.0 | 1.3 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.700 | 5.5e-04 |
| astrocytic glioma | -1.700 | 1.3e-02 |
| Astrocytoma, Pilocytic | -1.300 | 1.2e-04 |
| atypical teratoid / rhabdoid tumor | -1.900 | 1.6e-05 |
| Breast cancer | -1.100 | 1.3e-09 |
| ependymoma | -1.500 | 2.1e-02 |
| glioblastoma | -1.500 | 2.2e-06 |
| group 4 medulloblastoma | 1.400 | 4.7e-04 |
| intraductal papillary-mucinous carcinoma... | 1.300 | 1.1e-02 |
| invasive ductal carcinoma | -1.100 | 8.4e-04 |
| lung adenocarcinoma | -1.200 | 8.7e-20 |
| malignant mesothelioma | 2.400 | 1.3e-08 |
| medulloblastoma, large-cell | -2.200 | 3.2e-05 |
| oligodendroglioma | -1.100 | 2.3e-02 |
| osteosarcoma | -1.661 | 3.7e-03 |
| ovarian cancer | -1.200 | 1.4e-06 |
| pituitary cancer | 1.300 | 6.3e-04 |
| primitive neuroectodermal tumor | 1.500 | 2.2e-03 |
| psoriasis | -1.500 | 3.5e-03 |
| subependymal giant cell astrocytoma | -1.955 | 4.4e-02 |
MAHSKTRTNDGKITYPPGVKEISDKISKEEMVRRLKMVVKTFMDMDQDSEEEKELYLNLALHLASDFFLK 1 - 70 HPDKDVRLLVACCLADIFRIYAPEAPYTSPDKLKDIFMFITRQLKGLEDTKSPQFNRYFYLLENIAWVKS 71 - 140 YNICFELEDSNEIFTQLYRTLFSVINNGHNQKVHMHMVDLMSSIICEGDTVSQELLDTVLVNLVPAHKNL 141 - 210 NKQAYDLAKALLKRTAQAIEPYITNFFNQVLMLGKTSISDLSEHVFDLILELYNIDSHLLLSVLPQLEFK 211 - 280 LKSNDNEERLQVVKLLAKMFGAKDSELASQNKPLWQCYLGRFNDIHVPIRLECVKFASHCLMNHPDLAKD 281 - 350 LTEYLKVRSHDPEEAIRHDVIVSIVTAAKKDILLVNDHLLNFVRERTLDKRWRVRKEAMMGLAQIYKKYA 351 - 420 LQSAAGKDAAKQIAWIKDKLLHIYYQNSIDDRLLVERIFAQYMVPHNLETTERMKCLYYLYATLDLNAVK 421 - 490 ALNEMWKCQNLLRHQVKDLLDLIKQPKTDASVKAIFSKVMVITRNLPDPGKAQDFMKKFTQVLEDDEKIR 491 - 560 KQLEVLVSPTCSCKQAEGCVREITKKLGNPKQPTNPFLEMIKFLLERIAPVHIDTESISALIKQVNKSID 561 - 630 GTADDEDEGVPTDQAIRAGLELLKVLSFTHPISFHSAETFESLLACLKMDDEKVAEAALQIFKNTGSKIE 631 - 700 EDFPHIRSALLPVLHHKSKKGPPRQAKYAIHCIHAIFSSKETQFAQIFEPLHKSLDPSNLEHLITPLVTI 701 - 770 GHIALLAPDQFAAPLKSLVATFIVKDLLMNDRLPGKKTTKLWVPDEEVSPETMVKIQAIKMMVRWLLGMK 771 - 840 NNHSKSGTSTLRLLTTILHSDGDLTEQGKISKPDMSRLRLAAGSAIVKLAQEPCYHEIITLEQYQLCALA 841 - 910 INDECYQVRQVFAQKLHKGLSRLRLPLEYMAICALCAKDPVKERRAHARQCLVKNINVRREYLKQHAAVS 911 - 980 EKLLSLLPEYVVPYTIHLLAHDPDYVKVQDIEQLKDVKECLWFVLEILMAKNENNSHAFIRKMVENIKQT 981 - 1050 KDAQGPDDAKMNEKLYTVCDVAMNIIMSKSTTYSLESPKDPVLPARFFTQPDKNFSNTKNYLPPEMKSFF 1051 - 1120 TPGKPKTTNVLGAVNKPLSSAGKQSQTKSSRMETVSNASSSSNPSSPGRIKGRLDSSEMDHSENEDYTMS 1121 - 1190 SPLPGKKSDKRDDSDLVRSELEKPRGRKKTPVTEQEEKLGMDDLTKLVQEQKPKGSQRSRKRGHTASESD 1191 - 1260 EQQWPEEKRLKEDILENEDEQNSPPKKGKRGRPPKPLGGGTPKEEPTMKTSKKGSKKKSGPPAPEEEEEE 1261 - 1330 ERQSGNTEQKSKSKQHRVSRRAQQRAESPESSAIESTQSTPQKGRGRPSKTPSPSQPKKNVRVGRSKQAA 1331 - 1400 TKENDSSEEVDVFQGSSPVDDIPQEETEEEEVSTVNVRRRSAKRERR 1401 - 1447 //
