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  6. PDZ and LIM domain protein 5

Tbio PDZ and LIM domain protein 5

May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons. May restrain postsynaptic growth of excitatory synapses (By similarity).

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]

 Comments

Property Summary

NCBI Gene PubMed Count 49
PubMed Score 370.39
PubTator Score 297.77

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (6)

Disease Target Count Z-score Confidence
Myocardial Ischemia 169 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8
Disease Target Count Z-score Confidence
Prostate cancer 175 0.0 3.0
Disease Target Count Z-score Confidence
Hepatitis B 108 3.952 2.0
Nephrogenic adenofibroma 4 3.073 1.5
Hepatitis 67 3.001 1.5

Expression

  Differential Expression (34)

Disease log2 FC p
acute quadriplegic myopathy 1.146 3.6e-05
adult high grade glioma 1.200 1.6e-02
aldosterone-producing adenoma -1.067 1.8e-02
Amyotrophic lateral sclerosis 1.097 2.3e-06
astrocytic glioma 2.500 1.7e-02
Astrocytoma, Pilocytic 1.900 3.6e-06
atypical teratoid / rhabdoid tumor 2.500 9.6e-05
Becker muscular dystrophy -1.038 2.8e-02
Breast cancer 3.000 2.5e-02
dermatomyositis 1.200 1.5e-02
Down syndrome 1.100 5.6e-03
ependymoma 1.900 4.0e-02
glioblastoma 1.300 1.0e-03
group 4 medulloblastoma -1.100 1.1e-02
hereditary spastic paraplegia -1.031 4.1e-02
intraductal papillary-mucinous adenoma (... 2.100 9.3e-04
intraductal papillary-mucinous carcinoma... 2.100 7.6e-04
intraductal papillary-mucinous neoplasm ... 2.200 5.9e-03
malignant mesothelioma -1.100 7.9e-05
medulloblastoma, large-cell 2.000 2.2e-05
non-small cell lung cancer 1.306 4.3e-09
oligodendroglioma 2.600 1.0e-03
osteosarcoma 3.146 2.1e-06
ovarian cancer -1.100 1.3e-07
pancreatic cancer 1.100 2.7e-02
Pick disease 1.400 2.3e-04
pituitary cancer -1.600 1.5e-04
primary pancreatic ductal adenocarcinoma 1.136 1.1e-02
primitive neuroectodermal tumor 1.400 5.3e-04
psoriasis -4.400 5.0e-05
Rheumatoid arthritis 1.200 2.0e-02
spina bifida -1.209 3.5e-02
subependymal giant cell astrocytoma 1.732 2.1e-02
tuberculosis -1.700 2.4e-06

Synonym

Accession Q96HC4 A8K6F9 D6RB78 E9PBF5 O60705 Q56VN4 Q5UW38 Q8WVK0
Symbols L9
ENH
LIM
ENH1

Gene

PDLIM5

PANTHER Protein Class (3)

PDB

2DAR   2UZC  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (21)

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 GO Function (6)

 GO Component (7)

 GO Process (3)

 Compartment GO Term (40)

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 MGI Phenotype (5)

 GWAS Trait (10)

 HCA RNA Cell Line (56)

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Pathway (3)

Protein-protein Interaction (1)

TPM2  

Gene RIF (32)

AA Sequence 

MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQGMTHLEAQNKI      1 - 70
KGCTGSLNMTLQRASAAPKPEPVPVQKGEPKEVVKPVPITSPAVSKVTSTNNMAYNKAPRPFGSVSSPKV     71 - 140
TSIPSPSSAFTPAHATTSSHASPSPVAAVTPPLFAASGLHANANLSADQSPSALSAGKTAVNVPRQPTVT    141 - 210
SVCSETSQELAEGQRRGSQGDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQS    211 - 280
RSFRILAQITGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMPESLDSPTSGRPGVTSLTAAAAFK    281 - 350
PVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMC    351 - 420
AHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV    421 - 490
ISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDMFLEALGYTWH    491 - 560
DTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF                                      561 - 596
//

Text Mined References (64)

PMID Year Title